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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: APC All Species: 4.55
Human Site: S2749 Identified Species: 8.33
UniProt: P25054 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P25054 NP_000029.2 2843 311646 S2749 Q N N P V P V S E T N E S S I
Chimpanzee Pan troglodytes XP_001143509 2844 311637 S2750 Q N N P V P V S E T N E S S I
Rhesus Macaque Macaca mulatta XP_001095216 2303 243755 E2210 S S T S P S L E S R E P P G A
Dog Lupus familis XP_536285 2273 247246 E2180 S N P V P A P E A N E S C A A
Cat Felis silvestris
Mouse Mus musculus Q61315 2845 311071 A2751 Q S N P V S I A E T A E T C I
Rat Rattus norvegicus P70478 2842 310514 A2748 Q G S P A P V A E T G E T C M
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001511806 2844 309621 P2750 Q S N P T P A P E P G E S S V
Chicken Gallus gallus XP_001233411 2232 244958 E2139 T N P V P A P E N N E S T V S
Frog Xenopus laevis P70039 2829 310863 Q2735 K S L I N N Q Q E T N E N T V
Zebra Danio Brachydanio rerio NP_001137312 2754 301074 K2660 D K K V T D I K P A P S N P N
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_477152 2417 261266 P2324 R V S S T T P P S R S N S N L
Honey Bee Apis mellifera XP_624558 2760 306907 R2667 S R L G S F I R V D S A N G E
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_783363 3212 346162 N3114 G E L S I S R N V Q N Q R S R
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.4 35 74.2 N.A. 90.4 90.1 N.A. 86.7 67.1 75 68 N.A. 23.8 22.8 N.A. 29.1
Protein Similarity: 100 99.5 49.4 76.1 N.A. 94.2 94.3 N.A. 92.7 72.2 84 78.2 N.A. 41 42 N.A. 45.1
P-Site Identity: 100 100 0 6.6 N.A. 53.3 46.6 N.A. 53.3 6.6 26.6 0 N.A. 6.6 0 N.A. 13.3
P-Site Similarity: 100 100 13.3 13.3 N.A. 80 73.3 N.A. 66.6 13.3 60 13.3 N.A. 40 20 N.A. 33.3
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 8 16 8 16 8 8 8 8 0 8 16 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 8 16 0 % C
% Asp: 8 0 0 0 0 8 0 0 0 8 0 0 0 0 0 % D
% Glu: 0 8 0 0 0 0 0 24 47 0 24 47 0 0 8 % E
% Phe: 0 0 0 0 0 8 0 0 0 0 0 0 0 0 0 % F
% Gly: 8 8 0 8 0 0 0 0 0 0 16 0 0 16 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 8 8 0 24 0 0 0 0 0 0 0 24 % I
% Lys: 8 8 8 0 0 0 0 8 0 0 0 0 0 0 0 % K
% Leu: 0 0 24 0 0 0 8 0 0 0 0 0 0 0 8 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 8 % M
% Asn: 0 31 31 0 8 8 0 8 8 16 31 8 24 8 8 % N
% Pro: 0 0 16 39 24 31 24 16 8 8 8 8 8 8 0 % P
% Gln: 39 0 0 0 0 0 8 8 0 8 0 8 0 0 0 % Q
% Arg: 8 8 0 0 0 0 8 8 0 16 0 0 8 0 8 % R
% Ser: 24 31 16 24 8 24 0 16 16 0 16 24 31 31 8 % S
% Thr: 8 0 8 0 24 8 0 0 0 39 0 0 24 8 0 % T
% Val: 0 8 0 24 24 0 24 0 16 0 0 0 0 8 16 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _