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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
APC
All Species:
32.12
Human Site:
T600
Identified Species:
58.89
UniProt:
P25054
Number Species:
12
Phosphosite Substitution
Charge Score:
0.17
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P25054
NP_000029.2
2843
311646
T600
W
N
L
S
A
H
C
T
E
N
K
A
D
I
C
Chimpanzee
Pan troglodytes
XP_001143509
2844
311637
T600
W
N
L
S
A
H
C
T
E
N
K
A
D
I
C
Rhesus Macaque
Macaca mulatta
XP_001095216
2303
243755
S124
K
D
S
F
G
E
L
S
R
A
T
I
R
L
L
Dog
Lupus familis
XP_536285
2273
247246
L94
E
N
N
C
L
Q
T
L
L
Q
H
L
K
S
H
Cat
Felis silvestris
Mouse
Mus musculus
Q61315
2845
311071
T598
W
N
L
S
A
H
C
T
E
N
K
A
D
I
C
Rat
Rattus norvegicus
P70478
2842
310514
T598
W
N
L
S
A
H
C
T
E
N
K
A
D
I
C
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001511806
2844
309621
T600
W
N
L
S
A
H
C
T
E
N
K
A
E
I
C
Chicken
Gallus gallus
XP_001233411
2232
244958
G53
E
V
L
K
Q
L
Q
G
S
I
E
D
E
A
I
Frog
Xenopus laevis
P70039
2829
310863
T602
W
N
L
S
A
H
C
T
E
N
K
A
D
I
C
Zebra Danio
Brachydanio rerio
NP_001137312
2754
301074
D550
R
N
L
S
W
R
A
D
V
N
S
K
K
I
L
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_477152
2417
261266
D237
L
S
M
L
G
S
N
D
P
L
E
M
A
K
K
Honey Bee
Apis mellifera
XP_624558
2760
306907
S578
W
N
L
S
A
H
C
S
T
N
K
V
D
I
C
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_783363
3212
346162
T573
W
N
L
S
A
H
C
T
E
N
K
A
D
I
C
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.4
35
74.2
N.A.
90.4
90.1
N.A.
86.7
67.1
75
68
N.A.
23.8
22.8
N.A.
29.1
Protein Similarity:
100
99.5
49.4
76.1
N.A.
94.2
94.3
N.A.
92.7
72.2
84
78.2
N.A.
41
42
N.A.
45.1
P-Site Identity:
100
100
0
6.6
N.A.
100
100
N.A.
93.3
6.6
100
33.3
N.A.
0
80
N.A.
100
P-Site Similarity:
100
100
20
6.6
N.A.
100
100
N.A.
100
20
100
33.3
N.A.
20
86.6
N.A.
100
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
62
0
8
0
0
8
0
54
8
8
0
% A
% Cys:
0
0
0
8
0
0
62
0
0
0
0
0
0
0
62
% C
% Asp:
0
8
0
0
0
0
0
16
0
0
0
8
54
0
0
% D
% Glu:
16
0
0
0
0
8
0
0
54
0
16
0
16
0
0
% E
% Phe:
0
0
0
8
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
16
0
0
8
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
62
0
0
0
0
8
0
0
0
8
% H
% Ile:
0
0
0
0
0
0
0
0
0
8
0
8
0
70
8
% I
% Lys:
8
0
0
8
0
0
0
0
0
0
62
8
16
8
8
% K
% Leu:
8
0
77
8
8
8
8
8
8
8
0
8
0
8
16
% L
% Met:
0
0
8
0
0
0
0
0
0
0
0
8
0
0
0
% M
% Asn:
0
77
8
0
0
0
8
0
0
70
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
8
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
8
8
8
0
0
8
0
0
0
0
0
% Q
% Arg:
8
0
0
0
0
8
0
0
8
0
0
0
8
0
0
% R
% Ser:
0
8
8
70
0
8
0
16
8
0
8
0
0
8
0
% S
% Thr:
0
0
0
0
0
0
8
54
8
0
8
0
0
0
0
% T
% Val:
0
8
0
0
0
0
0
0
8
0
0
8
0
0
0
% V
% Trp:
62
0
0
0
8
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _