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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: GUCY2C All Species: 36.67
Human Site: S568 Identified Species: 67.22
UniProt: P25092 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P25092 NP_004954.2 1073 123369 S568 I E Y C E R G S L R E V L N D
Chimpanzee Pan troglodytes XP_528746 1073 123536 S568 I E Y C E R G S L R E V L N D
Rhesus Macaque Macaca mulatta XP_001089601 1073 123492 S568 I E Y C E R G S L R E V L N D
Dog Lupus familis XP_543798 1072 122882 S566 I E Y C E R G S L R E V L N D
Cat Felis silvestris
Mouse Mus musculus Q3UWA6 1072 123214 S568 V E Y C E R G S L R E V L N D
Rat Rattus norvegicus P23897 1072 123448 S567 V E Y C E R G S L R E V L N D
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001520217 1075 122497 S569 I E Y C E R G S L R D V L N D
Chicken Gallus gallus XP_416207 1070 123254 S565 I E Y C E R G S L R D V L N D
Frog Xenopus laevis NP_001079334 1065 122503 S560 I E Y C D K G S L R D V L N D
Zebra Danio Brachydanio rerio XP_700803 484 55110
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q07553 1163 130896 Y606 S V I I F T T Y C A R G S L E
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans Q09435 1137 128085 L638 H F I S V T K L C S R G S L Q
Sea Urchin Strong. purpuratus P16065 1125 126238 A573 M K N M V M S A I S V I S N A
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.2 97.5 87.7 N.A. 81.8 82.4 N.A. 73.5 67.7 62.4 31.4 N.A. 27.9 N.A. 24.8 28.6
Protein Similarity: 100 99.5 98.7 93.5 N.A. 90.1 90.7 N.A. 83.7 80.6 77 37.3 N.A. 45.2 N.A. 45.2 46.3
P-Site Identity: 100 100 100 100 N.A. 93.3 93.3 N.A. 93.3 93.3 80 0 N.A. 0 N.A. 0 6.6
P-Site Similarity: 100 100 100 100 N.A. 100 100 N.A. 100 100 100 0 N.A. 6.6 N.A. 0 40
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 0 0 8 0 8 0 0 0 0 8 % A
% Cys: 0 0 0 70 0 0 0 0 16 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 8 0 0 0 0 0 24 0 0 0 70 % D
% Glu: 0 70 0 0 62 0 0 0 0 0 47 0 0 0 8 % E
% Phe: 0 8 0 0 8 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 0 0 0 0 70 0 0 0 0 16 0 0 0 % G
% His: 8 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 54 0 16 8 0 0 0 0 8 0 0 8 0 0 0 % I
% Lys: 0 8 0 0 0 8 8 0 0 0 0 0 0 0 0 % K
% Leu: 0 0 0 0 0 0 0 8 70 0 0 0 70 16 0 % L
% Met: 8 0 0 8 0 8 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 8 0 0 0 0 0 0 0 0 0 0 77 0 % N
% Pro: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % P
% Gln: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 8 % Q
% Arg: 0 0 0 0 0 62 0 0 0 70 16 0 0 0 0 % R
% Ser: 8 0 0 8 0 0 8 70 0 16 0 0 24 0 0 % S
% Thr: 0 0 0 0 0 16 8 0 0 0 0 0 0 0 0 % T
% Val: 16 8 0 0 16 0 0 0 0 0 8 70 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 70 0 0 0 0 8 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _