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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
GUCY2C
All Species:
33.64
Human Site:
Y508
Identified Species:
61.67
UniProt:
P25092
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P25092
NP_004954.2
1073
123369
Y508
Q
R
L
R
Q
C
K
Y
D
K
K
R
V
I
L
Chimpanzee
Pan troglodytes
XP_528746
1073
123536
Y508
Q
R
L
R
Q
C
K
Y
D
K
K
R
V
I
L
Rhesus Macaque
Macaca mulatta
XP_001089601
1073
123492
Y508
Q
R
L
R
Q
C
K
Y
D
K
K
R
V
I
L
Dog
Lupus familis
XP_543798
1072
122882
Y506
Q
R
L
R
Q
C
K
Y
D
K
K
R
V
I
L
Cat
Felis silvestris
Mouse
Mus musculus
Q3UWA6
1072
123214
Y508
Q
R
V
R
Q
C
K
Y
D
K
K
K
V
I
L
Rat
Rattus norvegicus
P23897
1072
123448
Y507
Q
R
V
R
Q
C
K
Y
D
K
K
K
V
I
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001520217
1075
122497
Y509
P
R
L
R
Q
G
K
Y
D
K
K
I
V
I
L
Chicken
Gallus gallus
XP_416207
1070
123254
Y505
Q
R
L
R
Q
G
K
Y
D
K
K
V
V
I
L
Frog
Xenopus laevis
NP_001079334
1065
122503
Y501
P
R
L
Q
I
R
K
Y
D
K
K
V
V
I
L
Zebra Danio
Brachydanio rerio
XP_700803
484
55110
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q07553
1163
130896
K542
L
V
V
G
E
P
N
K
R
S
F
T
N
I
A
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q09435
1137
128085
G566
S
A
P
S
I
S
T
G
H
S
G
V
T
T
V
Sea Urchin
Strong. purpuratus
P16065
1125
126238
L509
E
L
C
T
N
W
A
L
Y
L
G
A
S
I
P
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.2
97.5
87.7
N.A.
81.8
82.4
N.A.
73.5
67.7
62.4
31.4
N.A.
27.9
N.A.
24.8
28.6
Protein Similarity:
100
99.5
98.7
93.5
N.A.
90.1
90.7
N.A.
83.7
80.6
77
37.3
N.A.
45.2
N.A.
45.2
46.3
P-Site Identity:
100
100
100
100
N.A.
86.6
86.6
N.A.
80
86.6
66.6
0
N.A.
6.6
N.A.
0
6.6
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
80
86.6
73.3
0
N.A.
20
N.A.
6.6
13.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
8
0
0
0
0
8
0
0
0
0
8
0
0
8
% A
% Cys:
0
0
8
0
0
47
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
70
0
0
0
0
0
0
% D
% Glu:
8
0
0
0
8
0
0
0
0
0
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
8
0
0
0
0
% F
% Gly:
0
0
0
8
0
16
0
8
0
0
16
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
8
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
16
0
0
0
0
0
0
8
0
85
0
% I
% Lys:
0
0
0
0
0
0
70
8
0
70
70
16
0
0
0
% K
% Leu:
8
8
54
0
0
0
0
8
0
8
0
0
0
0
70
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
8
0
8
0
0
0
0
0
8
0
0
% N
% Pro:
16
0
8
0
0
8
0
0
0
0
0
0
0
0
8
% P
% Gln:
54
0
0
8
62
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
70
0
62
0
8
0
0
8
0
0
31
0
0
0
% R
% Ser:
8
0
0
8
0
8
0
0
0
16
0
0
8
0
0
% S
% Thr:
0
0
0
8
0
0
8
0
0
0
0
8
8
8
0
% T
% Val:
0
8
24
0
0
0
0
0
0
0
0
24
70
0
8
% V
% Trp:
0
0
0
0
0
8
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
70
8
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _