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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
GUCY2C
All Species:
35.76
Human Site:
Y542
Identified Species:
65.56
UniProt:
P25092
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.17
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P25092
NP_004954.2
1073
123369
Y542
K
L
L
Q
I
D
Y
Y
N
L
T
K
F
Y
G
Chimpanzee
Pan troglodytes
XP_528746
1073
123536
Y542
K
L
L
Q
I
D
Y
Y
N
L
T
K
F
Y
G
Rhesus Macaque
Macaca mulatta
XP_001089601
1073
123492
Y542
K
L
L
Q
I
D
Y
Y
N
L
T
K
F
Y
G
Dog
Lupus familis
XP_543798
1072
122882
Y540
K
L
L
Q
I
D
Y
Y
N
L
T
K
F
Y
G
Cat
Felis silvestris
Mouse
Mus musculus
Q3UWA6
1072
123214
Y542
K
L
L
Q
S
D
Y
Y
N
L
T
K
F
Y
G
Rat
Rattus norvegicus
P23897
1072
123448
Y541
K
L
L
Q
S
D
Y
Y
N
L
T
K
F
Y
G
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001520217
1075
122497
Y543
K
L
L
Q
V
D
Y
Y
N
L
T
K
F
Y
G
Chicken
Gallus gallus
XP_416207
1070
123254
Y539
K
L
L
Q
I
D
Y
Y
N
L
T
K
F
Y
G
Frog
Xenopus laevis
NP_001079334
1065
122503
Y534
K
L
L
Q
I
D
Y
Y
N
L
T
K
F
Y
G
Zebra Danio
Brachydanio rerio
XP_700803
484
55110
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q07553
1163
130896
R580
R
K
E
L
K
L
M
R
E
V
R
H
E
N
I
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q09435
1137
128085
R612
K
E
R
F
V
K
M
R
K
L
D
H
E
N
I
Sea Urchin
Strong. purpuratus
P16065
1125
126238
V547
L
D
S
L
V
W
K
V
D
W
S
E
V
Q
T
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.2
97.5
87.7
N.A.
81.8
82.4
N.A.
73.5
67.7
62.4
31.4
N.A.
27.9
N.A.
24.8
28.6
Protein Similarity:
100
99.5
98.7
93.5
N.A.
90.1
90.7
N.A.
83.7
80.6
77
37.3
N.A.
45.2
N.A.
45.2
46.3
P-Site Identity:
100
100
100
100
N.A.
93.3
93.3
N.A.
93.3
100
100
0
N.A.
0
N.A.
13.3
0
P-Site Similarity:
100
100
100
100
N.A.
93.3
93.3
N.A.
100
100
100
0
N.A.
13.3
N.A.
20
26.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
8
0
0
0
70
0
0
8
0
8
0
0
0
0
% D
% Glu:
0
8
8
0
0
0
0
0
8
0
0
8
16
0
0
% E
% Phe:
0
0
0
8
0
0
0
0
0
0
0
0
70
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
70
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
16
0
0
0
% H
% Ile:
0
0
0
0
47
0
0
0
0
0
0
0
0
0
16
% I
% Lys:
77
8
0
0
8
8
8
0
8
0
0
70
0
0
0
% K
% Leu:
8
70
70
16
0
8
0
0
0
77
0
0
0
0
0
% L
% Met:
0
0
0
0
0
0
16
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
70
0
0
0
0
16
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
70
0
0
0
0
0
0
0
0
0
8
0
% Q
% Arg:
8
0
8
0
0
0
0
16
0
0
8
0
0
0
0
% R
% Ser:
0
0
8
0
16
0
0
0
0
0
8
0
0
0
0
% S
% Thr:
0
0
0
0
0
0
0
0
0
0
70
0
0
0
8
% T
% Val:
0
0
0
0
24
0
0
8
0
8
0
0
8
0
0
% V
% Trp:
0
0
0
0
0
8
0
0
0
8
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
70
70
0
0
0
0
0
70
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _