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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MCM3
All Species:
23.94
Human Site:
S681
Identified Species:
37.62
UniProt:
P25205
Number Species:
14
Phosphosite Substitution
Charge Score:
0.36
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P25205
NP_002379.2
808
90981
S681
T
E
D
E
E
E
K
S
Q
E
D
Q
E
Q
K
Chimpanzee
Pan troglodytes
XP_001151750
808
90957
S681
T
E
D
E
E
E
K
S
Q
E
D
Q
E
Q
K
Rhesus Macaque
Macaca mulatta
XP_001106966
808
90990
S681
T
E
D
E
E
E
K
S
Q
E
D
Q
E
Q
K
Dog
Lupus familis
XP_538960
916
102667
S789
T
D
D
E
E
E
K
S
Q
E
D
Q
E
Q
K
Cat
Felis silvestris
Mouse
Mus musculus
P25206
812
91528
S681
L
E
D
E
E
E
K
S
Q
E
D
T
E
Q
K
Rat
Rattus norvegicus
XP_001070728
813
91641
S681
L
E
D
E
E
E
K
S
Q
E
E
D
T
E
Q
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Q5ZMN2
812
91233
E682
T
E
K
E
E
E
E
E
E
T
Q
P
E
K
E
Frog
Xenopus laevis
Q7ZXZ0
806
90528
D681
E
E
E
Q
T
Q
P
D
G
E
G
K
K
R
R
Zebra Danio
Brachydanio rerio
NP_997732
807
90502
E680
S
E
D
E
E
E
E
E
D
E
A
Q
D
T
P
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_511048
819
90900
A675
A
E
D
D
N
G
E
A
S
S
Q
R
S
P
S
Honey Bee
Apis mellifera
XP_625020
811
91329
E679
T
D
G
E
N
Q
N
E
K
K
K
K
R
A
K
Nematode Worm
Caenorhab. elegans
Q21902
759
84917
E638
P
I
T
V
R
Q
L
E
A
I
V
R
I
A
E
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Q43704
768
85163
I644
L
Q
V
L
N
F
A
I
Y
H
K
E
L
T
E
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9FL33
776
86338
Q654
Q
E
E
R
Q
R
E
Q
A
E
Q
E
R
T
P
Baker's Yeast
Sacchar. cerevisiae
P24279
971
107499
S765
S
K
R
S
P
Q
K
S
P
K
K
R
Q
R
V
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.7
99.5
86
N.A.
92.9
93.3
N.A.
N.A.
81.4
80.1
75.9
N.A.
62.5
62.7
30.8
N.A.
Protein Similarity:
100
99.8
100
87.2
N.A.
96.6
97
N.A.
N.A.
92
90.7
88.1
N.A.
80
78.6
49.5
N.A.
P-Site Identity:
100
100
100
93.3
N.A.
86.6
60
N.A.
N.A.
40
13.3
46.6
N.A.
13.3
20
0
N.A.
P-Site Similarity:
100
100
100
100
N.A.
86.6
80
N.A.
N.A.
66.6
60
66.6
N.A.
40
53.3
20
N.A.
Percent
Protein Identity:
N.A.
47.6
N.A.
49.3
39.8
N.A.
Protein Similarity:
N.A.
66
N.A.
68.1
54.7
N.A.
P-Site Identity:
N.A.
0
N.A.
13.3
13.3
N.A.
P-Site Similarity:
N.A.
20
N.A.
40
60
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
7
0
0
0
0
0
7
7
14
0
7
0
0
14
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
14
54
7
0
0
0
7
7
0
34
7
7
0
0
% D
% Glu:
7
67
14
60
54
54
27
27
7
60
7
14
40
7
20
% E
% Phe:
0
0
0
0
0
7
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
7
0
0
7
0
0
7
0
7
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
7
0
0
0
0
0
% H
% Ile:
0
7
0
0
0
0
0
7
0
7
0
0
7
0
0
% I
% Lys:
0
7
7
0
0
0
47
0
7
14
20
14
7
7
40
% K
% Leu:
20
0
0
7
0
0
7
0
0
0
0
0
7
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
20
0
7
0
0
0
0
0
0
0
0
% N
% Pro:
7
0
0
0
7
0
7
0
7
0
0
7
0
7
14
% P
% Gln:
7
7
0
7
7
27
0
7
40
0
20
34
7
34
7
% Q
% Arg:
0
0
7
7
7
7
0
0
0
0
0
20
14
14
7
% R
% Ser:
14
0
0
7
0
0
0
47
7
7
0
0
7
0
7
% S
% Thr:
40
0
7
0
7
0
0
0
0
7
0
7
7
20
0
% T
% Val:
0
0
7
7
0
0
0
0
0
0
7
0
0
0
7
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
7
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _