KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
|
Home
|
Kinexus
|
Contact
|
Credits
Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MCM3
All Species:
37.58
Human Site:
T290
Identified Species:
59.05
UniProt:
P25205
Number Species:
14
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P25205
NP_002379.2
808
90981
T290
K
I
K
K
F
S
K
T
R
S
K
D
I
F
D
Chimpanzee
Pan troglodytes
XP_001151750
808
90957
T290
K
I
K
K
F
S
K
T
R
S
K
D
I
F
D
Rhesus Macaque
Macaca mulatta
XP_001106966
808
90990
T290
K
I
K
K
F
S
K
T
R
S
K
D
I
F
D
Dog
Lupus familis
XP_538960
916
102667
T398
K
I
K
K
F
S
K
T
R
S
K
D
I
F
D
Cat
Felis silvestris
Mouse
Mus musculus
P25206
812
91528
T290
K
I
K
K
F
S
K
T
R
S
K
D
V
F
E
Rat
Rattus norvegicus
XP_001070728
813
91641
T290
K
I
K
K
F
S
K
T
R
S
K
D
V
F
E
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Q5ZMN2
812
91233
S291
K
I
K
R
F
S
K
S
R
S
K
D
I
F
N
Frog
Xenopus laevis
Q7ZXZ0
806
90528
S290
K
I
K
K
F
S
K
S
H
S
K
D
V
F
E
Zebra Danio
Brachydanio rerio
NP_997732
807
90502
S289
K
I
K
S
F
C
R
S
R
S
K
N
V
F
D
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_511048
819
90900
N287
L
C
K
K
L
A
K
N
N
D
I
F
E
L
L
Honey Bee
Apis mellifera
XP_625020
811
91329
N286
M
C
K
K
L
A
K
N
N
P
C
K
N
I
F
Nematode Worm
Caenorhab. elegans
Q21902
759
84917
G268
G
N
R
V
T
I
V
G
V
Y
S
I
K
K
L
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Q43704
768
85163
E276
N
A
P
V
Y
T
R
E
D
L
K
R
M
K
E
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9FL33
776
86338
R281
D
N
I
K
N
I
A
R
R
D
D
A
F
D
L
Baker's Yeast
Sacchar. cerevisiae
P24279
971
107499
S354
I
R
N
I
N
K
L
S
K
K
K
D
I
F
D
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.7
99.5
86
N.A.
92.9
93.3
N.A.
N.A.
81.4
80.1
75.9
N.A.
62.5
62.7
30.8
N.A.
Protein Similarity:
100
99.8
100
87.2
N.A.
96.6
97
N.A.
N.A.
92
90.7
88.1
N.A.
80
78.6
49.5
N.A.
P-Site Identity:
100
100
100
100
N.A.
86.6
86.6
N.A.
N.A.
80
73.3
60
N.A.
20
20
0
N.A.
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
N.A.
100
93.3
86.6
N.A.
26.6
26.6
6.6
N.A.
Percent
Protein Identity:
N.A.
47.6
N.A.
49.3
39.8
N.A.
Protein Similarity:
N.A.
66
N.A.
68.1
54.7
N.A.
P-Site Identity:
N.A.
6.6
N.A.
13.3
33.3
N.A.
P-Site Similarity:
N.A.
40
N.A.
13.3
46.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
7
0
0
0
14
7
0
0
0
0
7
0
0
0
% A
% Cys:
0
14
0
0
0
7
0
0
0
0
7
0
0
0
0
% C
% Asp:
7
0
0
0
0
0
0
0
7
14
7
60
0
7
40
% D
% Glu:
0
0
0
0
0
0
0
7
0
0
0
0
7
0
27
% E
% Phe:
0
0
0
0
60
0
0
0
0
0
0
7
7
67
7
% F
% Gly:
7
0
0
0
0
0
0
7
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
7
0
0
0
0
0
0
% H
% Ile:
7
60
7
7
0
14
0
0
0
0
7
7
40
7
0
% I
% Lys:
60
0
74
67
0
7
67
0
7
7
74
7
7
14
0
% K
% Leu:
7
0
0
0
14
0
7
0
0
7
0
0
0
7
20
% L
% Met:
7
0
0
0
0
0
0
0
0
0
0
0
7
0
0
% M
% Asn:
7
14
7
0
14
0
0
14
14
0
0
7
7
0
7
% N
% Pro:
0
0
7
0
0
0
0
0
0
7
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
7
7
7
0
0
14
7
60
0
0
7
0
0
0
% R
% Ser:
0
0
0
7
0
54
0
27
0
60
7
0
0
0
0
% S
% Thr:
0
0
0
0
7
7
0
40
0
0
0
0
0
0
0
% T
% Val:
0
0
0
14
0
0
7
0
7
0
0
0
27
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
7
0
0
0
0
7
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _