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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: MPST All Species: 29.7
Human Site: S218 Identified Species: 54.44
UniProt: P25325 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0.17
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P25325 NP_001013454.1 297 33178 S218 I P F T D F L S Q E G L E K S
Chimpanzee Pan troglodytes XP_001159671 317 35336 T238 I P F T D F L T Q E G L E K S
Rhesus Macaque Macaca mulatta XP_001084731 297 33430 T218 I P F T D F L T Q E G L E K S
Dog Lupus familis XP_531744 298 33112 T219 I P F T D F L T S E G L E K S
Cat Felis silvestris
Mouse Mus musculus Q99J99 297 33005 T218 I P F T E F L T N E G L E K S
Rat Rattus norvegicus P97532 297 32922 T218 I P F T E F L T S E G L E K S
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001517033 297 32917 T218 M P F T D F L T E Q G L E K S
Chicken Gallus gallus P25324 289 32268 F212 V N M P F S T F L T E S G H E
Frog Xenopus laevis NP_001090542 299 33515 S220 V P F P S F L S A E G Y E K S
Zebra Danio Brachydanio rerio NP_001082815 296 32900 D216 M P F P S F M D P E S G L E R
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans O17730 328 36929 V248 L P S A E L L V K G G N L K S
Sea Urchin Strong. purpuratus XP_784555 302 33055 N216 V P F S T L L N D D D S E R A
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae Q08686 304 34200 D221 L P Y G S L L D P E T K T Y P
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 92.4 93.5 91.2 N.A. 84.1 84.8 N.A. 80.4 58.5 67.2 57.9 N.A. N.A. N.A. 25.2 46
Protein Similarity: 100 93 96.3 95.3 N.A. 92.2 92.9 N.A. 91.2 76.4 79.2 76 N.A. N.A. N.A. 44.8 64.2
P-Site Identity: 100 93.3 93.3 86.6 N.A. 80 80 N.A. 73.3 0 66.6 26.6 N.A. N.A. N.A. 33.3 26.6
P-Site Similarity: 100 100 100 93.3 N.A. 93.3 93.3 N.A. 100 6.6 73.3 46.6 N.A. N.A. N.A. 53.3 66.6
Percent
Protein Identity: N.A. N.A. N.A. N.A. 34.2 N.A.
Protein Similarity: N.A. N.A. N.A. N.A. 50.6 N.A.
P-Site Identity: N.A. N.A. N.A. N.A. 20 N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. 33.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 8 0 0 0 0 8 0 0 0 0 0 8 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 39 0 0 16 8 8 8 0 0 0 0 % D
% Glu: 0 0 0 0 24 0 0 0 8 70 8 0 70 8 8 % E
% Phe: 0 0 77 0 8 70 0 8 0 0 0 0 0 0 0 % F
% Gly: 0 0 0 8 0 0 0 0 0 8 70 8 8 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 8 0 % H
% Ile: 47 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % I
% Lys: 0 0 0 0 0 0 0 0 8 0 0 8 0 70 0 % K
% Leu: 16 0 0 0 0 24 85 0 8 0 0 54 16 0 0 % L
% Met: 16 0 8 0 0 0 8 0 0 0 0 0 0 0 0 % M
% Asn: 0 8 0 0 0 0 0 8 8 0 0 8 0 0 0 % N
% Pro: 0 93 0 24 0 0 0 0 16 0 0 0 0 0 8 % P
% Gln: 0 0 0 0 0 0 0 0 24 8 0 0 0 0 0 % Q
% Arg: 0 0 0 0 0 0 0 0 0 0 0 0 0 8 8 % R
% Ser: 0 0 8 8 24 8 0 16 16 0 8 16 0 0 70 % S
% Thr: 0 0 0 54 8 0 8 47 0 8 8 0 8 0 0 % T
% Val: 24 0 0 0 0 0 0 8 0 0 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 8 0 0 0 0 0 0 0 0 8 0 8 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _