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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: CTSS All Species: 9.7
Human Site: S94 Identified Species: 21.33
UniProt: P25774 Number Species: 10
    Phosphosite Substitution
    Charge Score: -0.1
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P25774 NP_004070.3 331 37496 S94 E V M S L M S S L R V P S Q W
Chimpanzee Pan troglodytes XP_001171268 331 37376 S94 E V M S L M S S L R V P S Q W
Rhesus Macaque Macaca mulatta NP_001027984 329 36923 K94 V Q K M T G L K V P A S H S R
Dog Lupus familis
Cat Felis silvestris
Mouse Mus musculus O70370 340 38420 A102 E I S C R M G A L R I S R Q S
Rat Rattus norvegicus Q02765 330 36815 S92 E V I G Y M G S L R I P R P W
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001518002 618 66856 T380 E E V V R T M T G L K V P P A
Chicken Gallus gallus Q90686 334 37200 T96 E E V V R T M T G L R V P R S
Frog Xenopus laevis NP_001086670 320 35636 P84 K M T G L I L P P H S E R K A
Zebra Danio Brachydanio rerio NP_001017661 330 36275 V93 E I L Q T L A V T R V P P G F
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q95029 371 41582 Q133 F N Y T L H K Q L R A A D E S
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana P43297 462 50948 G114 E Y R S K Y L G A K M E K K G
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99 55.5 N.A. N.A. 71.7 73.4 N.A. 30.4 48.2 61 58.3 N.A. 43.9 N.A. N.A. N.A.
Protein Similarity: 100 99.4 71 N.A. N.A. 84.1 83.3 N.A. 39.3 62.2 77 73.4 N.A. 57.4 N.A. N.A. N.A.
P-Site Identity: 100 100 0 N.A. N.A. 33.3 53.3 N.A. 6.6 6.6 6.6 26.6 N.A. 20 N.A. N.A. N.A.
P-Site Similarity: 100 100 6.6 N.A. N.A. 53.3 66.6 N.A. 20 26.6 33.3 60 N.A. 33.3 N.A. N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. 30.5 N.A. N.A.
Protein Similarity: N.A. N.A. N.A. 45.4 N.A. N.A.
P-Site Identity: N.A. N.A. N.A. 13.3 N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. 33.3 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 0 10 10 10 0 19 10 0 0 19 % A
% Cys: 0 0 0 10 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 0 0 0 0 0 0 10 0 0 % D
% Glu: 73 19 0 0 0 0 0 0 0 0 0 19 0 10 0 % E
% Phe: 10 0 0 0 0 0 0 0 0 0 0 0 0 0 10 % F
% Gly: 0 0 0 19 0 10 19 10 19 0 0 0 0 10 10 % G
% His: 0 0 0 0 0 10 0 0 0 10 0 0 10 0 0 % H
% Ile: 0 19 10 0 0 10 0 0 0 0 19 0 0 0 0 % I
% Lys: 10 0 10 0 10 0 10 10 0 10 10 0 10 19 0 % K
% Leu: 0 0 10 0 37 10 28 0 46 19 0 0 0 0 0 % L
% Met: 0 10 19 10 0 37 19 0 0 0 10 0 0 0 0 % M
% Asn: 0 10 0 0 0 0 0 0 0 0 0 0 0 0 0 % N
% Pro: 0 0 0 0 0 0 0 10 10 10 0 37 28 19 0 % P
% Gln: 0 10 0 10 0 0 0 10 0 0 0 0 0 28 0 % Q
% Arg: 0 0 10 0 28 0 0 0 0 55 10 0 28 10 10 % R
% Ser: 0 0 10 28 0 0 19 28 0 0 10 19 19 10 28 % S
% Thr: 0 0 10 10 19 19 0 19 10 0 0 0 0 0 0 % T
% Val: 10 28 19 19 0 0 0 10 10 0 28 19 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 28 % W
% Tyr: 0 10 10 0 10 10 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _