Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.

Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PSMA2 All Species: 22.12
Human Site: T224 Identified Species: 32.44
UniProt: P25787 Number Species: 15
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P25787 NP_002778.1 234 25899 T224 G F R R L T P T E V K D Y L A
Chimpanzee Pan troglodytes
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_856136 183 20122 L174 Y V N G K T F L E K R K A L K
Cat Felis silvestris
Mouse Mus musculus P49722 234 25907 T224 G F R R L T P T E V R D Y L A
Rat Rattus norvegicus P17220 234 25908 T224 G F R R L T P T E V R D Y L A
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001506542 234 25889 T224 G F R R L T P T E V K D Y L A
Chicken Gallus gallus NP_001012878 234 25901 T224 G F R R L T P T E V K D Y L A
Frog Xenopus laevis P24495 234 25816 A224 G F K R L T P A E V K D Y L A
Zebra Danio Brachydanio rerio NP_001019612 234 25886 A224 G F R R L T P A E V K D Y L A
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P40301 234 25888 A224 G F Q R L D P A S I K D Y L A
Honey Bee Apis mellifera XP_393294 234 25782 S224 G F R R L E P S N V K D Y L A
Nematode Worm Caenorhab. elegans Q27488 231 25317 Q222 G F H R L T K Q Q V H D H L G
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa XP_002318902 235 25607 A225 Q F R V L T P A E I D D Y L A
Maize Zea mays NP_001132248 235 25846 A225 E F K V L S P A E I K D F L E
Rice Oryza sativa
Thale Cress Arabidopsis thaliana O23708 235 25683 A225 V F R V L T P A E I D D Y L A
Baker's Yeast Sacchar. cerevisiae P23639 250 27143 Q241 R F R K L T S Q E I N D R L E
Red Bread Mold Neurospora crassa Q8X077 249 26979 Q240 R F R K L S P Q E I E D Y L T
Conservation
Percent
Protein Identity: 100 N.A. N.A. 77.7 N.A. 99.1 99.5 N.A. 99.5 98.2 95.7 95.3 N.A. 77.7 81.6 64.9 N.A.
Protein Similarity: 100 N.A. N.A. 77.7 N.A. 100 100 N.A. 99.5 99.1 97.4 97.4 N.A. 89.3 89.3 79 N.A.
P-Site Identity: 100 N.A. N.A. 20 N.A. 93.3 93.3 N.A. 100 100 86.6 93.3 N.A. 66.6 80 53.3 N.A.
P-Site Similarity: 100 N.A. N.A. 26.6 N.A. 100 100 N.A. 100 100 93.3 93.3 N.A. 80 86.6 66.6 N.A.
Percent
Protein Identity: 65.1 65.5 N.A. 65.5 57.2 62.6
Protein Similarity: 81.2 81.2 N.A. 80.8 69.6 73.4
P-Site Identity: 66.6 46.6 N.A. 66.6 46.6 53.3
P-Site Similarity: 73.3 73.3 N.A. 73.3 60 80
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 0 0 38 0 0 0 0 7 0 69 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 7 0 0 0 0 13 94 0 0 0 % D
% Glu: 7 0 0 0 0 7 0 0 82 0 7 0 0 0 13 % E
% Phe: 0 94 0 0 0 0 7 0 0 0 0 0 7 0 0 % F
% Gly: 63 0 0 7 0 0 0 0 0 0 0 0 0 0 7 % G
% His: 0 0 7 0 0 0 0 0 0 0 7 0 7 0 0 % H
% Ile: 0 0 0 0 0 0 0 0 0 38 0 0 0 0 0 % I
% Lys: 0 0 13 13 7 0 7 0 0 7 50 7 0 0 7 % K
% Leu: 0 0 0 0 94 0 0 7 0 0 0 0 0 100 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 7 0 0 0 0 0 7 0 7 0 0 0 0 % N
% Pro: 0 0 0 0 0 0 82 0 0 0 0 0 0 0 0 % P
% Gln: 7 0 7 0 0 0 0 19 7 0 0 0 0 0 0 % Q
% Arg: 13 0 69 63 0 0 0 0 0 0 19 0 7 0 0 % R
% Ser: 0 0 0 0 0 13 7 7 7 0 0 0 0 0 0 % S
% Thr: 0 0 0 0 0 75 0 32 0 0 0 0 0 0 7 % T
% Val: 7 7 0 19 0 0 0 0 0 57 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 7 0 0 0 0 0 0 0 0 0 0 0 75 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _