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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: NFKBIA All Species: 8.18
Human Site: T257 Identified Species: 16.36
UniProt: P25963 Number Species: 11
    Phosphosite Substitution
    Charge Score: -0.09
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P25963 NP_065390.1 317 35609 T257 G Y S P Y Q L T W G R P S T R
Chimpanzee Pan troglodytes XP_001168452 534 57746 I291 D G T T P L H I A A G R G S T
Rhesus Macaque Macaca mulatta XP_001087842 317 35574 T257 G Y S P Y Q L T W G R P S T R
Dog Lupus familis XP_537413 515 57309 Y455 T Y Q G Y S P Y Q L T W G R P
Cat Felis silvestris
Mouse Mus musculus Q9Z1E3 314 35053 Y254 T Y Q G Y S P Y Q L T W G R P
Rat Rattus norvegicus Q63746 314 34999 Y254 T Y Q G Y S P Y Q L T W G R P
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001519324 329 36001 Y269 T Y Q G Y S P Y Q L T W G R E
Chicken Gallus gallus Q91974 318 35380 Y258 T Y Q G Y S P Y Q L T W G R D
Frog Xenopus laevis NP_001086998 315 35926 C256 T Y Q G Y S P C Q L T W G R N
Zebra Danio Brachydanio rerio NP_955923 312 34594 Y251 T Y G G H T P Y H L T Y G R S
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q03017 500 53800 Q436 Y A G L T A Y Q F A C I M N K
Honey Bee Apis mellifera NP_001157184 384 42622 R295 R G A D L N A R E G L A G R T
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 22.8 99.6 58 N.A. 91.1 90.8 N.A. 77.8 71.6 59.9 47.3 N.A. 23.7 30.9 N.A. N.A.
Protein Similarity: 100 35.9 100 59.8 N.A. 94 94 N.A. 85.1 82 75.7 66.2 N.A. 37.2 48.4 N.A. N.A.
P-Site Identity: 100 0 100 13.3 N.A. 13.3 13.3 N.A. 13.3 13.3 13.3 6.6 N.A. 0 6.6 N.A. N.A.
P-Site Similarity: 100 13.3 100 13.3 N.A. 13.3 13.3 N.A. 13.3 13.3 13.3 13.3 N.A. 13.3 13.3 N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 9 9 0 0 9 9 0 9 17 0 9 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 9 0 0 9 0 0 0 0 % C
% Asp: 9 0 0 9 0 0 0 0 0 0 0 0 0 0 9 % D
% Glu: 0 0 0 0 0 0 0 0 9 0 0 0 0 0 9 % E
% Phe: 0 0 0 0 0 0 0 0 9 0 0 0 0 0 0 % F
% Gly: 17 17 17 59 0 0 0 0 0 25 9 0 75 0 0 % G
% His: 0 0 0 0 9 0 9 0 9 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 0 0 9 0 0 0 9 0 0 0 % I
% Lys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 9 % K
% Leu: 0 0 0 9 9 9 17 0 0 59 9 0 0 0 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 9 0 0 % M
% Asn: 0 0 0 0 0 9 0 0 0 0 0 0 0 9 9 % N
% Pro: 0 0 0 17 9 0 59 0 0 0 0 17 0 0 25 % P
% Gln: 0 0 50 0 0 17 0 9 50 0 0 0 0 0 0 % Q
% Arg: 9 0 0 0 0 0 0 9 0 0 17 9 0 67 17 % R
% Ser: 0 0 17 0 0 50 0 0 0 0 0 0 17 9 9 % S
% Thr: 59 0 9 9 9 9 0 17 0 0 59 0 0 17 17 % T
% Val: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 17 0 0 50 0 0 0 % W
% Tyr: 9 75 0 0 67 0 9 50 0 0 0 9 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _