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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
DNMT1
All Species:
31.52
Human Site:
S1434
Identified Species:
63.03
UniProt:
P26358
Number Species:
11
Phosphosite Substitution
Charge Score:
-0.09
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P26358
NP_001124295.1
1616
183165
S1434
H
I
P
L
A
P
G
S
D
W
R
D
L
P
N
Chimpanzee
Pan troglodytes
XP_001163722
1671
188922
S1489
H
I
P
L
A
P
G
S
D
W
R
D
L
P
N
Rhesus Macaque
Macaca mulatta
XP_001104704
1455
164736
K1302
R
Y
T
H
H
D
R
K
N
G
R
S
S
S
G
Dog
Lupus familis
XP_533919
1645
185708
S1465
H
I
P
L
A
P
G
S
D
W
R
D
L
P
N
Cat
Felis silvestris
Mouse
Mus musculus
P13864
1620
183170
S1437
H
I
P
L
F
P
G
S
D
W
R
D
L
P
N
Rat
Rattus norvegicus
Q9Z330
1622
182755
S1439
H
I
P
L
S
P
G
S
D
W
R
D
L
P
N
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Q92072
1537
172889
S1349
H
I
P
L
A
P
G
S
D
W
R
D
L
P
N
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
XP_002661304
1500
169062
S1318
N
I
P
L
A
P
G
S
D
W
R
D
L
P
N
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
NP_001164522
1366
157059
G1221
T
H
D
D
K
K
A
G
R
S
S
V
G
A
Y
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_780273
1618
181959
S1432
H
I
P
L
A
P
G
S
D
W
R
D
L
P
N
Poplar Tree
Populus trichocarpa
XP_002305346
1529
172691
N1360
K
T
N
L
E
Y
G
N
D
P
V
S
W
F
Q
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P34881
1534
172412
N1387
D
H
I
C
K
A
M
N
E
L
N
L
I
R
C
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
96.6
88.4
89.6
N.A.
78
76.5
N.A.
N.A.
72.4
N.A.
66.1
N.A.
N.A.
47.5
N.A.
54.5
Protein Similarity:
100
96.7
88.9
93.6
N.A.
87
85.6
N.A.
N.A.
81.5
N.A.
76.9
N.A.
N.A.
62.2
N.A.
69.9
P-Site Identity:
100
100
6.6
100
N.A.
93.3
93.3
N.A.
N.A.
100
N.A.
93.3
N.A.
N.A.
0
N.A.
100
P-Site Similarity:
100
100
13.3
100
N.A.
93.3
100
N.A.
N.A.
100
N.A.
100
N.A.
N.A.
0
N.A.
100
Percent
Protein Identity:
26.4
N.A.
N.A.
26.9
N.A.
N.A.
Protein Similarity:
45.4
N.A.
N.A.
43.6
N.A.
N.A.
P-Site Identity:
20
N.A.
N.A.
0
N.A.
N.A.
P-Site Similarity:
26.6
N.A.
N.A.
20
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
50
9
9
0
0
0
0
0
0
9
0
% A
% Cys:
0
0
0
9
0
0
0
0
0
0
0
0
0
0
9
% C
% Asp:
9
0
9
9
0
9
0
0
75
0
0
67
0
0
0
% D
% Glu:
0
0
0
0
9
0
0
0
9
0
0
0
0
0
0
% E
% Phe:
0
0
0
0
9
0
0
0
0
0
0
0
0
9
0
% F
% Gly:
0
0
0
0
0
0
75
9
0
9
0
0
9
0
9
% G
% His:
59
17
0
9
9
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
67
9
0
0
0
0
0
0
0
0
0
9
0
0
% I
% Lys:
9
0
0
0
17
9
0
9
0
0
0
0
0
0
0
% K
% Leu:
0
0
0
75
0
0
0
0
0
9
0
9
67
0
0
% L
% Met:
0
0
0
0
0
0
9
0
0
0
0
0
0
0
0
% M
% Asn:
9
0
9
0
0
0
0
17
9
0
9
0
0
0
67
% N
% Pro:
0
0
67
0
0
67
0
0
0
9
0
0
0
67
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
9
% Q
% Arg:
9
0
0
0
0
0
9
0
9
0
75
0
0
9
0
% R
% Ser:
0
0
0
0
9
0
0
67
0
9
9
17
9
9
0
% S
% Thr:
9
9
9
0
0
0
0
0
0
0
0
0
0
0
0
% T
% Val:
0
0
0
0
0
0
0
0
0
0
9
9
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
67
0
0
9
0
0
% W
% Tyr:
0
9
0
0
0
9
0
0
0
0
0
0
0
0
9
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _