KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
|
Home
|
Kinexus
|
Contact
|
Credits
Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
DNMT1
All Species:
14.24
Human Site:
S161
Identified Species:
28.48
UniProt:
P26358
Number Species:
11
Phosphosite Substitution
Charge Score:
-0.09
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P26358
NP_001124295.1
1616
183165
S161
S
P
R
I
T
R
K
S
T
R
Q
T
T
I
T
Chimpanzee
Pan troglodytes
XP_001163722
1671
188922
S216
S
P
R
I
T
R
K
S
T
R
Q
T
T
I
T
Rhesus Macaque
Macaca mulatta
XP_001104704
1455
164736
S162
D
E
D
E
K
Q
D
S
F
S
K
T
T
K
N
Dog
Lupus familis
XP_533919
1645
185708
T196
S
P
R
I
T
R
Q
T
T
R
Q
T
T
I
L
Cat
Felis silvestris
Mouse
Mus musculus
P13864
1620
183170
T160
S
V
A
T
R
R
T
T
R
Q
T
T
I
T
A
Rat
Rattus norvegicus
Q9Z330
1622
182755
Q161
A
T
R
R
T
T
R
Q
T
T
I
T
S
H
F
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Q92072
1537
172889
K158
L
P
A
P
R
A
R
K
A
R
R
S
R
S
N
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
XP_002661304
1500
169062
N156
A
S
S
R
V
T
R
N
T
G
K
Q
Q
T
I
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
NP_001164522
1366
157059
P88
D
V
N
I
L
P
T
P
Q
I
K
N
I
N
I
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_780273
1618
181959
S178
K
K
K
K
K
K
G
S
P
G
G
S
E
G
G
Poplar Tree
Populus trichocarpa
XP_002305346
1529
172691
G168
Y
D
C
I
K
P
S
G
G
Y
K
K
F
F
D
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P34881
1534
172412
S170
D
C
R
K
P
A
A
S
Y
R
K
V
Y
D
Y
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
96.6
88.4
89.6
N.A.
78
76.5
N.A.
N.A.
72.4
N.A.
66.1
N.A.
N.A.
47.5
N.A.
54.5
Protein Similarity:
100
96.7
88.9
93.6
N.A.
87
85.6
N.A.
N.A.
81.5
N.A.
76.9
N.A.
N.A.
62.2
N.A.
69.9
P-Site Identity:
100
100
20
80
N.A.
20
26.6
N.A.
N.A.
13.3
N.A.
6.6
N.A.
N.A.
6.6
N.A.
6.6
P-Site Similarity:
100
100
33.3
93.3
N.A.
33.3
46.6
N.A.
N.A.
33.3
N.A.
33.3
N.A.
N.A.
13.3
N.A.
26.6
Percent
Protein Identity:
26.4
N.A.
N.A.
26.9
N.A.
N.A.
Protein Similarity:
45.4
N.A.
N.A.
43.6
N.A.
N.A.
P-Site Identity:
6.6
N.A.
N.A.
20
N.A.
N.A.
P-Site Similarity:
13.3
N.A.
N.A.
26.6
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
17
0
17
0
0
17
9
0
9
0
0
0
0
0
9
% A
% Cys:
0
9
9
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
25
9
9
0
0
0
9
0
0
0
0
0
0
9
9
% D
% Glu:
0
9
0
9
0
0
0
0
0
0
0
0
9
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
9
0
0
0
9
9
9
% F
% Gly:
0
0
0
0
0
0
9
9
9
17
9
0
0
9
9
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
9
0
% H
% Ile:
0
0
0
42
0
0
0
0
0
9
9
0
17
25
17
% I
% Lys:
9
9
9
17
25
9
17
9
0
0
42
9
0
9
0
% K
% Leu:
9
0
0
0
9
0
0
0
0
0
0
0
0
0
9
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
9
0
0
0
0
9
0
0
0
9
0
9
17
% N
% Pro:
0
34
0
9
9
17
0
9
9
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
9
9
9
9
9
25
9
9
0
0
% Q
% Arg:
0
0
42
17
17
34
25
0
9
42
9
0
9
0
0
% R
% Ser:
34
9
9
0
0
0
9
42
0
9
0
17
9
9
0
% S
% Thr:
0
9
0
9
34
17
17
17
42
9
9
50
34
17
17
% T
% Val:
0
17
0
0
9
0
0
0
0
0
0
9
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
9
0
0
0
0
0
0
0
9
9
0
0
9
0
9
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _