KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
|
Home
|
Kinexus
|
Contact
|
Credits
Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
DNMT1
All Species:
25.15
Human Site:
S732
Identified Species:
50.3
UniProt:
P26358
Number Species:
11
Phosphosite Substitution
Charge Score:
0.27
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P26358
NP_001124295.1
1616
183165
S732
K
Q
N
K
N
R
I
S
W
V
G
E
A
V
K
Chimpanzee
Pan troglodytes
XP_001163722
1671
188922
S787
K
Q
N
K
N
R
I
S
W
V
G
E
A
V
K
Rhesus Macaque
Macaca mulatta
XP_001104704
1455
164736
L644
C
A
G
T
D
T
V
L
G
A
T
S
D
P
L
Dog
Lupus familis
XP_533919
1645
185708
S763
K
Q
N
K
N
R
I
S
W
V
G
D
A
V
K
Cat
Felis silvestris
Mouse
Mus musculus
P13864
1620
183170
S735
K
Q
N
K
D
R
I
S
W
L
G
Q
P
M
K
Rat
Rattus norvegicus
Q9Z330
1622
182755
S736
K
Q
N
K
D
R
I
S
W
L
G
E
P
V
K
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Q92072
1537
172889
S644
K
Q
N
K
S
R
I
S
W
V
G
E
P
I
K
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
XP_002661304
1500
169062
E635
M
K
V
R
V
E
N
E
V
L
E
V
G
D
C
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
NP_001164522
1366
157059
D567
F
L
S
D
D
C
D
D
I
P
F
K
S
V
R
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_780273
1618
181959
T728
K
K
K
R
A
K
V
T
W
I
G
E
P
E
E
Poplar Tree
Populus trichocarpa
XP_002305346
1529
172691
A671
E
V
K
E
E
D
E
A
E
E
Q
Y
E
N
E
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P34881
1534
172412
D684
G
E
N
G
L
T
E
D
T
V
P
E
P
V
E
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
96.6
88.4
89.6
N.A.
78
76.5
N.A.
N.A.
72.4
N.A.
66.1
N.A.
N.A.
47.5
N.A.
54.5
Protein Similarity:
100
96.7
88.9
93.6
N.A.
87
85.6
N.A.
N.A.
81.5
N.A.
76.9
N.A.
N.A.
62.2
N.A.
69.9
P-Site Identity:
100
100
0
93.3
N.A.
66.6
80
N.A.
N.A.
80
N.A.
0
N.A.
N.A.
6.6
N.A.
26.6
P-Site Similarity:
100
100
13.3
100
N.A.
93.3
93.3
N.A.
N.A.
93.3
N.A.
20
N.A.
N.A.
40
N.A.
73.3
Percent
Protein Identity:
26.4
N.A.
N.A.
26.9
N.A.
N.A.
Protein Similarity:
45.4
N.A.
N.A.
43.6
N.A.
N.A.
P-Site Identity:
0
N.A.
N.A.
26.6
N.A.
N.A.
P-Site Similarity:
26.6
N.A.
N.A.
40
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
9
0
0
9
0
0
9
0
9
0
0
25
0
0
% A
% Cys:
9
0
0
0
0
9
0
0
0
0
0
0
0
0
9
% C
% Asp:
0
0
0
9
34
9
9
17
0
0
0
9
9
9
0
% D
% Glu:
9
9
0
9
9
9
17
9
9
9
9
50
9
9
25
% E
% Phe:
9
0
0
0
0
0
0
0
0
0
9
0
0
0
0
% F
% Gly:
9
0
9
9
0
0
0
0
9
0
59
0
9
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
50
0
9
9
0
0
0
9
0
% I
% Lys:
59
17
17
50
0
9
0
0
0
0
0
9
0
0
50
% K
% Leu:
0
9
0
0
9
0
0
9
0
25
0
0
0
0
9
% L
% Met:
9
0
0
0
0
0
0
0
0
0
0
0
0
9
0
% M
% Asn:
0
0
59
0
25
0
9
0
0
0
0
0
0
9
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
9
9
0
42
9
0
% P
% Gln:
0
50
0
0
0
0
0
0
0
0
9
9
0
0
0
% Q
% Arg:
0
0
0
17
0
50
0
0
0
0
0
0
0
0
9
% R
% Ser:
0
0
9
0
9
0
0
50
0
0
0
9
9
0
0
% S
% Thr:
0
0
0
9
0
17
0
9
9
0
9
0
0
0
0
% T
% Val:
0
9
9
0
9
0
17
0
9
42
0
9
0
50
0
% V
% Trp:
0
0
0
0
0
0
0
0
59
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
9
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _