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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
DNMT1
All Species:
21.82
Human Site:
T546
Identified Species:
43.64
UniProt:
P26358
Number Species:
11
Phosphosite Substitution
Charge Score:
0.09
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P26358
NP_001124295.1
1616
183165
T546
G
L
N
L
N
R
F
T
E
D
S
L
L
R
H
Chimpanzee
Pan troglodytes
XP_001163722
1671
188922
T601
G
L
N
L
N
R
F
T
E
D
S
L
L
R
H
Rhesus Macaque
Macaca mulatta
XP_001104704
1455
164736
C509
E
C
G
K
C
K
A
C
K
D
M
V
K
F
G
Dog
Lupus familis
XP_533919
1645
185708
T578
V
L
N
L
N
R
F
T
E
D
S
L
L
R
H
Cat
Felis silvestris
Mouse
Mus musculus
P13864
1620
183170
T552
T
I
N
V
N
R
F
T
E
D
S
L
L
R
H
Rat
Rattus norvegicus
Q9Z330
1622
182755
T552
A
I
N
V
N
R
F
T
E
D
S
L
L
R
H
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Q92072
1537
172889
V509
T
L
G
K
R
R
A
V
R
R
Q
A
I
R
H
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
XP_002661304
1500
169062
T503
G
P
T
K
A
T
T
T
K
L
V
Y
L
I
F
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
NP_001164522
1366
157059
A435
K
R
R
C
P
N
M
A
I
Q
E
A
D
D
S
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_780273
1618
181959
D541
G
C
N
R
F
T
E
D
T
L
L
R
H
A
Q
Poplar Tree
Populus trichocarpa
XP_002305346
1529
172691
S530
Q
S
R
V
S
R
L
S
F
A
D
V
I
R
K
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P34881
1534
172412
S545
A
N
D
K
A
Y
I
S
S
D
P
L
A
V
E
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
96.6
88.4
89.6
N.A.
78
76.5
N.A.
N.A.
72.4
N.A.
66.1
N.A.
N.A.
47.5
N.A.
54.5
Protein Similarity:
100
96.7
88.9
93.6
N.A.
87
85.6
N.A.
N.A.
81.5
N.A.
76.9
N.A.
N.A.
62.2
N.A.
69.9
P-Site Identity:
100
100
6.6
93.3
N.A.
80
80
N.A.
N.A.
26.6
N.A.
20
N.A.
N.A.
0
N.A.
13.3
P-Site Similarity:
100
100
26.6
93.3
N.A.
93.3
93.3
N.A.
N.A.
33.3
N.A.
26.6
N.A.
N.A.
0
N.A.
13.3
Percent
Protein Identity:
26.4
N.A.
N.A.
26.9
N.A.
N.A.
Protein Similarity:
45.4
N.A.
N.A.
43.6
N.A.
N.A.
P-Site Identity:
13.3
N.A.
N.A.
13.3
N.A.
N.A.
P-Site Similarity:
46.6
N.A.
N.A.
26.6
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
17
0
0
0
17
0
17
9
0
9
0
17
9
9
0
% A
% Cys:
0
17
0
9
9
0
0
9
0
0
0
0
0
0
0
% C
% Asp:
0
0
9
0
0
0
0
9
0
59
9
0
9
9
0
% D
% Glu:
9
0
0
0
0
0
9
0
42
0
9
0
0
0
9
% E
% Phe:
0
0
0
0
9
0
42
0
9
0
0
0
0
9
9
% F
% Gly:
34
0
17
0
0
0
0
0
0
0
0
0
0
0
9
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
9
0
50
% H
% Ile:
0
17
0
0
0
0
9
0
9
0
0
0
17
9
0
% I
% Lys:
9
0
0
34
0
9
0
0
17
0
0
0
9
0
9
% K
% Leu:
0
34
0
25
0
0
9
0
0
17
9
50
50
0
0
% L
% Met:
0
0
0
0
0
0
9
0
0
0
9
0
0
0
0
% M
% Asn:
0
9
50
0
42
9
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
9
0
0
9
0
0
0
0
0
9
0
0
0
0
% P
% Gln:
9
0
0
0
0
0
0
0
0
9
9
0
0
0
9
% Q
% Arg:
0
9
17
9
9
59
0
0
9
9
0
9
0
59
0
% R
% Ser:
0
9
0
0
9
0
0
17
9
0
42
0
0
0
9
% S
% Thr:
17
0
9
0
0
17
9
50
9
0
0
0
0
0
0
% T
% Val:
9
0
0
25
0
0
0
9
0
0
9
17
0
9
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
9
0
0
0
0
0
9
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _