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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
DNMT1
All Species:
5.15
Human Site:
T603
Identified Species:
10.3
UniProt:
P26358
Number Species:
11
Phosphosite Substitution
Charge Score:
-0.18
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P26358
NP_001124295.1
1616
183165
T603
R
A
Q
A
R
R
Q
T
I
R
H
S
T
R
E
Chimpanzee
Pan troglodytes
XP_001163722
1671
188922
T658
R
A
Q
A
R
R
Q
T
I
R
H
S
T
R
E
Rhesus Macaque
Macaca mulatta
XP_001104704
1455
164736
N566
Q
G
K
K
K
K
Q
N
K
N
R
I
S
W
V
Dog
Lupus familis
XP_533919
1645
185708
I635
R
A
E
R
R
Q
T
I
G
H
S
A
K
E
K
Cat
Felis silvestris
Mouse
Mus musculus
P13864
1620
183170
G609
R
A
T
R
R
V
M
G
A
T
K
E
K
D
K
Rat
Rattus norvegicus
Q9Z330
1622
182755
I609
R
A
T
R
R
T
V
I
N
S
A
K
V
K
R
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Q92072
1537
172889
G566
A
M
K
R
R
R
C
G
V
C
E
V
C
Q
Q
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
XP_002661304
1500
169062
R560
I
K
F
G
G
S
G
R
S
K
Q
A
C
Q
K
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
NP_001164522
1366
157059
Y492
N
D
N
L
K
T
Y
Y
K
S
V
I
V
G
D
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_780273
1618
181959
K598
T
R
K
A
A
A
V
K
K
D
K
K
P
V
F
Poplar Tree
Populus trichocarpa
XP_002305346
1529
172691
G587
K
K
C
A
F
V
V
G
L
T
R
K
M
E
E
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P34881
1534
172412
I602
W
I
I
K
K
K
K
I
S
L
K
E
L
N
L
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
96.6
88.4
89.6
N.A.
78
76.5
N.A.
N.A.
72.4
N.A.
66.1
N.A.
N.A.
47.5
N.A.
54.5
Protein Similarity:
100
96.7
88.9
93.6
N.A.
87
85.6
N.A.
N.A.
81.5
N.A.
76.9
N.A.
N.A.
62.2
N.A.
69.9
P-Site Identity:
100
100
6.6
20
N.A.
20
20
N.A.
N.A.
13.3
N.A.
0
N.A.
N.A.
0
N.A.
6.6
P-Site Similarity:
100
100
40
46.6
N.A.
26.6
26.6
N.A.
N.A.
40
N.A.
26.6
N.A.
N.A.
13.3
N.A.
13.3
Percent
Protein Identity:
26.4
N.A.
N.A.
26.9
N.A.
N.A.
Protein Similarity:
45.4
N.A.
N.A.
43.6
N.A.
N.A.
P-Site Identity:
13.3
N.A.
N.A.
0
N.A.
N.A.
P-Site Similarity:
26.6
N.A.
N.A.
20
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
9
42
0
34
9
9
0
0
9
0
9
17
0
0
0
% A
% Cys:
0
0
9
0
0
0
9
0
0
9
0
0
17
0
0
% C
% Asp:
0
9
0
0
0
0
0
0
0
9
0
0
0
9
9
% D
% Glu:
0
0
9
0
0
0
0
0
0
0
9
17
0
17
25
% E
% Phe:
0
0
9
0
9
0
0
0
0
0
0
0
0
0
9
% F
% Gly:
0
9
0
9
9
0
9
25
9
0
0
0
0
9
0
% G
% His:
0
0
0
0
0
0
0
0
0
9
17
0
0
0
0
% H
% Ile:
9
9
9
0
0
0
0
25
17
0
0
17
0
0
0
% I
% Lys:
9
17
25
17
25
17
9
9
25
9
25
25
17
9
25
% K
% Leu:
0
0
0
9
0
0
0
0
9
9
0
0
9
0
9
% L
% Met:
0
9
0
0
0
0
9
0
0
0
0
0
9
0
0
% M
% Asn:
9
0
9
0
0
0
0
9
9
9
0
0
0
9
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
9
0
0
% P
% Gln:
9
0
17
0
0
9
25
0
0
0
9
0
0
17
9
% Q
% Arg:
42
9
0
34
50
25
0
9
0
17
17
0
0
17
9
% R
% Ser:
0
0
0
0
0
9
0
0
17
17
9
17
9
0
0
% S
% Thr:
9
0
17
0
0
17
9
17
0
17
0
0
17
0
0
% T
% Val:
0
0
0
0
0
17
25
0
9
0
9
9
17
9
9
% V
% Trp:
9
0
0
0
0
0
0
0
0
0
0
0
0
9
0
% W
% Tyr:
0
0
0
0
0
0
9
9
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _