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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
DNMT1
All Species:
6.67
Human Site:
T616
Identified Species:
13.33
UniProt:
P26358
Number Species:
11
Phosphosite Substitution
Charge Score:
-0.09
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P26358
NP_001124295.1
1616
183165
T616
R
E
K
D
R
G
P
T
K
A
T
T
T
K
L
Chimpanzee
Pan troglodytes
XP_001163722
1671
188922
T671
R
E
K
D
R
G
P
T
K
A
T
T
T
K
L
Rhesus Macaque
Macaca mulatta
XP_001104704
1455
164736
T579
W
V
G
E
A
V
K
T
D
G
K
K
S
Y
Y
Dog
Lupus familis
XP_533919
1645
185708
K648
E
K
D
K
G
P
T
K
A
T
T
T
K
L
V
Cat
Felis silvestris
Mouse
Mus musculus
P13864
1620
183170
T622
D
K
A
P
T
K
A
T
T
T
K
L
V
Y
Q
Rat
Rattus norvegicus
Q9Z330
1622
182755
A622
K
R
K
G
P
T
K
A
T
T
T
K
L
V
Y
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Q92072
1537
172889
C579
Q
Q
P
E
C
G
K
C
K
A
C
Q
N
M
V
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
XP_002661304
1500
169062
L573
Q
K
R
R
C
P
N
L
A
V
K
E
A
E
D
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
NP_001164522
1366
157059
N505
G
D
E
E
I
G
I
N
D
Y
V
L
V
E
P
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_780273
1618
181959
T611
V
F
T
M
A
T
V
T
P
L
V
S
H
I
F
Poplar Tree
Populus trichocarpa
XP_002305346
1529
172691
W600
E
E
R
H
H
T
K
W
V
V
N
K
K
A
I
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P34881
1534
172412
M615
N
L
N
P
R
A
G
M
A
P
V
A
S
K
R
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
96.6
88.4
89.6
N.A.
78
76.5
N.A.
N.A.
72.4
N.A.
66.1
N.A.
N.A.
47.5
N.A.
54.5
Protein Similarity:
100
96.7
88.9
93.6
N.A.
87
85.6
N.A.
N.A.
81.5
N.A.
76.9
N.A.
N.A.
62.2
N.A.
69.9
P-Site Identity:
100
100
6.6
13.3
N.A.
6.6
13.3
N.A.
N.A.
20
N.A.
0
N.A.
N.A.
6.6
N.A.
6.6
P-Site Similarity:
100
100
20
26.6
N.A.
13.3
20
N.A.
N.A.
46.6
N.A.
26.6
N.A.
N.A.
33.3
N.A.
13.3
Percent
Protein Identity:
26.4
N.A.
N.A.
26.9
N.A.
N.A.
Protein Similarity:
45.4
N.A.
N.A.
43.6
N.A.
N.A.
P-Site Identity:
6.6
N.A.
N.A.
13.3
N.A.
N.A.
P-Site Similarity:
20
N.A.
N.A.
20
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
9
0
17
9
9
9
25
25
0
9
9
9
0
% A
% Cys:
0
0
0
0
17
0
0
9
0
0
9
0
0
0
0
% C
% Asp:
9
9
9
17
0
0
0
0
17
0
0
0
0
0
9
% D
% Glu:
17
25
9
25
0
0
0
0
0
0
0
9
0
17
0
% E
% Phe:
0
9
0
0
0
0
0
0
0
0
0
0
0
0
9
% F
% Gly:
9
0
9
9
9
34
9
0
0
9
0
0
0
0
0
% G
% His:
0
0
0
9
9
0
0
0
0
0
0
0
9
0
0
% H
% Ile:
0
0
0
0
9
0
9
0
0
0
0
0
0
9
9
% I
% Lys:
9
25
25
9
0
9
34
9
25
0
25
25
17
25
0
% K
% Leu:
0
9
0
0
0
0
0
9
0
9
0
17
9
9
17
% L
% Met:
0
0
0
9
0
0
0
9
0
0
0
0
0
9
0
% M
% Asn:
9
0
9
0
0
0
9
9
0
0
9
0
9
0
0
% N
% Pro:
0
0
9
17
9
17
17
0
9
9
0
0
0
0
9
% P
% Gln:
17
9
0
0
0
0
0
0
0
0
0
9
0
0
9
% Q
% Arg:
17
9
17
9
25
0
0
0
0
0
0
0
0
0
9
% R
% Ser:
0
0
0
0
0
0
0
0
0
0
0
9
17
0
0
% S
% Thr:
0
0
9
0
9
25
9
42
17
25
34
25
17
0
0
% T
% Val:
9
9
0
0
0
9
9
0
9
17
25
0
17
9
17
% V
% Trp:
9
0
0
0
0
0
0
9
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
9
0
0
0
17
17
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _