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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
DNMT1
All Species:
15.15
Human Site:
Y443
Identified Species:
30.3
UniProt:
P26358
Number Species:
11
Phosphosite Substitution
Charge Score:
0.09
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P26358
NP_001124295.1
1616
183165
Y443
S
G
S
A
K
P
I
Y
D
D
D
P
S
L
E
Chimpanzee
Pan troglodytes
XP_001163722
1671
188922
Y498
S
G
S
A
K
P
I
Y
D
D
D
P
S
L
E
Rhesus Macaque
Macaca mulatta
XP_001104704
1455
164736
D410
Y
D
E
A
G
D
S
D
E
Q
P
I
F
L
T
Dog
Lupus familis
XP_533919
1645
185708
Y475
S
G
Y
A
K
P
I
Y
D
D
D
P
S
L
E
Cat
Felis silvestris
Mouse
Mus musculus
P13864
1620
183170
H449
S
G
C
A
K
A
I
H
D
E
N
P
S
M
E
Rat
Rattus norvegicus
Q9Z330
1622
182755
H449
S
G
V
A
K
A
I
H
E
E
N
P
S
V
E
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Q92072
1537
172889
F410
S
E
E
Y
A
P
I
F
A
L
M
Q
E
K
I
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
XP_002661304
1500
169062
T404
L
Q
K
N
Q
D
A
T
Y
E
D
L
L
N
K
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
NP_001164522
1366
157059
L336
A
N
L
A
G
V
T
L
G
K
R
V
T
F
R
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_780273
1618
181959
Y438
S
G
Y
V
K
P
I
Y
D
E
N
S
S
I
E
Poplar Tree
Populus trichocarpa
XP_002305346
1529
172691
M430
T
I
F
G
S
G
R
M
T
E
D
D
G
S
G
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P34881
1534
172412
S438
D
D
N
G
S
W
I
S
L
N
D
P
D
S
G
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
96.6
88.4
89.6
N.A.
78
76.5
N.A.
N.A.
72.4
N.A.
66.1
N.A.
N.A.
47.5
N.A.
54.5
Protein Similarity:
100
96.7
88.9
93.6
N.A.
87
85.6
N.A.
N.A.
81.5
N.A.
76.9
N.A.
N.A.
62.2
N.A.
69.9
P-Site Identity:
100
100
13.3
93.3
N.A.
60
53.3
N.A.
N.A.
20
N.A.
6.6
N.A.
N.A.
6.6
N.A.
60
P-Site Similarity:
100
100
20
93.3
N.A.
86.6
86.6
N.A.
N.A.
26.6
N.A.
26.6
N.A.
N.A.
20
N.A.
80
Percent
Protein Identity:
26.4
N.A.
N.A.
26.9
N.A.
N.A.
Protein Similarity:
45.4
N.A.
N.A.
43.6
N.A.
N.A.
P-Site Identity:
6.6
N.A.
N.A.
20
N.A.
N.A.
P-Site Similarity:
20
N.A.
N.A.
33.3
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
9
0
0
59
9
17
9
0
9
0
0
0
0
0
0
% A
% Cys:
0
0
9
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
9
17
0
0
0
17
0
9
42
25
50
9
9
0
0
% D
% Glu:
0
9
17
0
0
0
0
0
17
42
0
0
9
0
50
% E
% Phe:
0
0
9
0
0
0
0
9
0
0
0
0
9
9
0
% F
% Gly:
0
50
0
17
17
9
0
0
9
0
0
0
9
0
17
% G
% His:
0
0
0
0
0
0
0
17
0
0
0
0
0
0
0
% H
% Ile:
0
9
0
0
0
0
67
0
0
0
0
9
0
9
9
% I
% Lys:
0
0
9
0
50
0
0
0
0
9
0
0
0
9
9
% K
% Leu:
9
0
9
0
0
0
0
9
9
9
0
9
9
34
0
% L
% Met:
0
0
0
0
0
0
0
9
0
0
9
0
0
9
0
% M
% Asn:
0
9
9
9
0
0
0
0
0
9
25
0
0
9
0
% N
% Pro:
0
0
0
0
0
42
0
0
0
0
9
50
0
0
0
% P
% Gln:
0
9
0
0
9
0
0
0
0
9
0
9
0
0
0
% Q
% Arg:
0
0
0
0
0
0
9
0
0
0
9
0
0
0
9
% R
% Ser:
59
0
17
0
17
0
9
9
0
0
0
9
50
17
0
% S
% Thr:
9
0
0
0
0
0
9
9
9
0
0
0
9
0
9
% T
% Val:
0
0
9
9
0
9
0
0
0
0
0
9
0
9
0
% V
% Trp:
0
0
0
0
0
9
0
0
0
0
0
0
0
0
0
% W
% Tyr:
9
0
17
9
0
0
0
34
9
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _