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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
DNMT1
All Species:
20.3
Human Site:
Y524
Identified Species:
40.61
UniProt:
P26358
Number Species:
11
Phosphosite Substitution
Charge Score:
-0.27
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P26358
NP_001124295.1
1616
183165
Y524
Q
S
N
S
D
S
T
Y
E
D
L
I
N
K
I
Chimpanzee
Pan troglodytes
XP_001163722
1671
188922
Y579
Q
S
N
S
D
S
T
Y
E
D
L
I
N
K
I
Rhesus Macaque
Macaca mulatta
XP_001104704
1455
164736
F487
R
E
D
K
E
N
A
F
K
R
R
R
C
G
V
Dog
Lupus familis
XP_533919
1645
185708
Y556
Q
S
N
P
D
S
T
Y
E
D
L
I
N
K
I
Cat
Felis silvestris
Mouse
Mus musculus
P13864
1620
183170
Y530
Q
N
N
P
D
A
V
Y
E
D
L
I
N
K
I
Rat
Rattus norvegicus
Q9Z330
1622
182755
Y530
Q
S
N
P
D
A
V
Y
E
D
L
I
N
K
I
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Q92072
1537
172889
L487
D
S
D
E
P
P
V
L
I
T
P
C
M
R
D
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
XP_002661304
1500
169062
R481
G
K
R
R
A
A
R
R
Q
A
V
R
H
P
T
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
NP_001164522
1366
157059
M413
L
C
N
A
C
K
D
M
I
K
F
G
G
T
G
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_780273
1618
181959
Y519
Q
S
T
Q
D
A
V
Y
E
D
L
L
S
Q
I
Poplar Tree
Populus trichocarpa
XP_002305346
1529
172691
K508
S
W
Y
K
P
V
L
K
T
V
K
L
A
R
S
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P34881
1534
172412
R523
R
V
E
S
R
V
A
R
L
S
F
A
D
V
T
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
96.6
88.4
89.6
N.A.
78
76.5
N.A.
N.A.
72.4
N.A.
66.1
N.A.
N.A.
47.5
N.A.
54.5
Protein Similarity:
100
96.7
88.9
93.6
N.A.
87
85.6
N.A.
N.A.
81.5
N.A.
76.9
N.A.
N.A.
62.2
N.A.
69.9
P-Site Identity:
100
100
0
93.3
N.A.
73.3
80
N.A.
N.A.
6.6
N.A.
0
N.A.
N.A.
6.6
N.A.
53.3
P-Site Similarity:
100
100
46.6
93.3
N.A.
86.6
86.6
N.A.
N.A.
20
N.A.
26.6
N.A.
N.A.
13.3
N.A.
80
Percent
Protein Identity:
26.4
N.A.
N.A.
26.9
N.A.
N.A.
Protein Similarity:
45.4
N.A.
N.A.
43.6
N.A.
N.A.
P-Site Identity:
0
N.A.
N.A.
6.6
N.A.
N.A.
P-Site Similarity:
13.3
N.A.
N.A.
20
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
9
9
34
17
0
0
9
0
9
9
0
0
% A
% Cys:
0
9
0
0
9
0
0
0
0
0
0
9
9
0
0
% C
% Asp:
9
0
17
0
50
0
9
0
0
50
0
0
9
0
9
% D
% Glu:
0
9
9
9
9
0
0
0
50
0
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
9
0
0
17
0
0
0
0
% F
% Gly:
9
0
0
0
0
0
0
0
0
0
0
9
9
9
9
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
9
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
17
0
0
42
0
0
50
% I
% Lys:
0
9
0
17
0
9
0
9
9
9
9
0
0
42
0
% K
% Leu:
9
0
0
0
0
0
9
9
9
0
50
17
0
0
0
% L
% Met:
0
0
0
0
0
0
0
9
0
0
0
0
9
0
0
% M
% Asn:
0
9
50
0
0
9
0
0
0
0
0
0
42
0
0
% N
% Pro:
0
0
0
25
17
9
0
0
0
0
9
0
0
9
0
% P
% Gln:
50
0
0
9
0
0
0
0
9
0
0
0
0
9
0
% Q
% Arg:
17
0
9
9
9
0
9
17
0
9
9
17
0
17
0
% R
% Ser:
9
50
0
25
0
25
0
0
0
9
0
0
9
0
9
% S
% Thr:
0
0
9
0
0
0
25
0
9
9
0
0
0
9
17
% T
% Val:
0
9
0
0
0
17
34
0
0
9
9
0
0
9
9
% V
% Trp:
0
9
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
9
0
0
0
0
50
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _