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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
DNMT1
All Species:
15.15
Human Site:
Y746
Identified Species:
30.3
UniProt:
P26358
Number Species:
11
Phosphosite Substitution
Charge Score:
0.18
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P26358
NP_001124295.1
1616
183165
Y746
K
T
D
G
K
K
S
Y
Y
K
K
V
C
I
D
Chimpanzee
Pan troglodytes
XP_001163722
1671
188922
Y801
K
T
D
G
K
K
S
Y
Y
K
K
V
C
I
D
Rhesus Macaque
Macaca mulatta
XP_001104704
1455
164736
E658
L
E
L
F
L
V
D
E
C
E
D
M
Q
L
S
Dog
Lupus familis
XP_533919
1645
185708
Y777
K
T
D
G
K
K
D
Y
Y
K
K
V
C
I
D
Cat
Felis silvestris
Mouse
Mus musculus
P13864
1620
183170
Y749
K
I
E
E
N
R
T
Y
Y
Q
K
V
S
I
D
Rat
Rattus norvegicus
Q9Z330
1622
182755
Y750
K
I
E
E
N
R
T
Y
Y
W
K
V
S
I
D
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Q92072
1537
172889
F658
K
S
D
G
K
K
D
F
Y
Q
R
V
C
I
D
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
XP_002661304
1500
169062
D649
C
V
S
V
S
P
D
D
P
S
H
P
L
Y
L
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
NP_001164522
1366
157059
F581
R
S
K
C
T
V
I
F
K
E
I
Q
K
N
W
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_780273
1618
181959
F742
E
V
T
K
D
R
A
F
Y
K
A
A
M
I
D
Poplar Tree
Populus trichocarpa
XP_002305346
1529
172691
V685
E
D
D
D
K
E
E
V
V
E
K
T
L
K
P
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P34881
1534
172412
P698
E
V
Q
K
P
H
T
P
K
K
I
R
G
S
S
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
96.6
88.4
89.6
N.A.
78
76.5
N.A.
N.A.
72.4
N.A.
66.1
N.A.
N.A.
47.5
N.A.
54.5
Protein Similarity:
100
96.7
88.9
93.6
N.A.
87
85.6
N.A.
N.A.
81.5
N.A.
76.9
N.A.
N.A.
62.2
N.A.
69.9
P-Site Identity:
100
100
0
93.3
N.A.
46.6
46.6
N.A.
N.A.
66.6
N.A.
0
N.A.
N.A.
0
N.A.
26.6
P-Site Similarity:
100
100
20
93.3
N.A.
73.3
66.6
N.A.
N.A.
93.3
N.A.
0
N.A.
N.A.
26.6
N.A.
53.3
Percent
Protein Identity:
26.4
N.A.
N.A.
26.9
N.A.
N.A.
Protein Similarity:
45.4
N.A.
N.A.
43.6
N.A.
N.A.
P-Site Identity:
20
N.A.
N.A.
6.6
N.A.
N.A.
P-Site Similarity:
40
N.A.
N.A.
20
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
9
0
0
0
9
9
0
0
0
% A
% Cys:
9
0
0
9
0
0
0
0
9
0
0
0
34
0
0
% C
% Asp:
0
9
42
9
9
0
34
9
0
0
9
0
0
0
59
% D
% Glu:
25
9
17
17
0
9
9
9
0
25
0
0
0
0
0
% E
% Phe:
0
0
0
9
0
0
0
25
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
34
0
0
0
0
0
0
0
0
9
0
0
% G
% His:
0
0
0
0
0
9
0
0
0
0
9
0
0
0
0
% H
% Ile:
0
17
0
0
0
0
9
0
0
0
17
0
0
59
0
% I
% Lys:
50
0
9
17
42
34
0
0
17
42
50
0
9
9
0
% K
% Leu:
9
0
9
0
9
0
0
0
0
0
0
0
17
9
9
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
9
9
0
0
% M
% Asn:
0
0
0
0
17
0
0
0
0
0
0
0
0
9
0
% N
% Pro:
0
0
0
0
9
9
0
9
9
0
0
9
0
0
9
% P
% Gln:
0
0
9
0
0
0
0
0
0
17
0
9
9
0
0
% Q
% Arg:
9
0
0
0
0
25
0
0
0
0
9
9
0
0
0
% R
% Ser:
0
17
9
0
9
0
17
0
0
9
0
0
17
9
17
% S
% Thr:
0
25
9
0
9
0
25
0
0
0
0
9
0
0
0
% T
% Val:
0
25
0
9
0
17
0
9
9
0
0
50
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
9
0
0
0
0
9
% W
% Tyr:
0
0
0
0
0
0
0
42
59
0
0
0
0
9
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _