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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: U2AF2 All Species: 26.36
Human Site: S239 Identified Species: 52.73
UniProt: P26368 Number Species: 11
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P26368 NP_001012496.1 475 53501 S239 Y Q P L P G M S E N P S V Y V
Chimpanzee Pan troglodytes XP_530073 713 78555 S481 Y Q P L P G M S E N P S V Y V
Rhesus Macaque Macaca mulatta XP_001091568 467 51268 S235 Y Q P L P G M S E N P S V Y V
Dog Lupus familis
Cat Felis silvestris
Mouse Mus musculus P26369 475 53499 S239 Y Q P L P G M S E N P S V Y V
Rat Rattus norvegicus Q63285 419 46487 Q205 R A P E A E L Q N C L A Q A G
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus
Frog Xenopus laevis NP_001080595 456 51328 S224 Y Q P L P G M S E N P S V Y V
Zebra Danio Brachydanio rerio NP_991252 475 53612 S242 Y Q P L P G M S E N P S V Y V
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q24562 416 46636 V202 S G V I S T V V P D S P H K I
Honey Bee Apis mellifera XP_623055 432 48801 P217 D N P S M N V P G T V P D S P
Nematode Worm Caenorhab. elegans P90978 496 55412 Q271 P R D Y Q P S Q N T F D M N S
Sea Urchin Strong. purpuratus XP_001189425 444 50005 S218 Y Q A I P G M S A T P T V H V
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q8L716 589 66297 N355 G P S Q P N P N L N L G A V G
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 53.4 87.5 N.A. N.A. 99.7 20 N.A. N.A. N.A. 92 86.3 N.A. 66.7 66.7 51.4 62.9
Protein Similarity: 100 57.2 89.2 N.A. N.A. 99.7 37.6 N.A. N.A. N.A. 94.7 92.2 N.A. 77 77.8 62.5 75.5
P-Site Identity: 100 100 100 N.A. N.A. 100 6.6 N.A. N.A. N.A. 100 100 N.A. 0 6.6 0 60
P-Site Similarity: 100 100 100 N.A. N.A. 100 20 N.A. N.A. N.A. 100 100 N.A. 26.6 13.3 13.3 80
Percent
Protein Identity: N.A. N.A. N.A. 37.6 N.A. N.A.
Protein Similarity: N.A. N.A. N.A. 50.7 N.A. N.A.
P-Site Identity: N.A. N.A. N.A. 13.3 N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. 20 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 9 9 0 9 0 0 0 9 0 0 9 9 9 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 9 0 0 0 0 0 % C
% Asp: 9 0 9 0 0 0 0 0 0 9 0 9 9 0 0 % D
% Glu: 0 0 0 9 0 9 0 0 50 0 0 0 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 9 0 0 0 0 % F
% Gly: 9 9 0 0 0 59 0 0 9 0 0 9 0 0 17 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 9 9 0 % H
% Ile: 0 0 0 17 0 0 0 0 0 0 0 0 0 0 9 % I
% Lys: 0 0 0 0 0 0 0 0 0 0 0 0 0 9 0 % K
% Leu: 0 0 0 50 0 0 9 0 9 0 17 0 0 0 0 % L
% Met: 0 0 0 0 9 0 59 0 0 0 0 0 9 0 0 % M
% Asn: 0 9 0 0 0 17 0 9 17 59 0 0 0 9 0 % N
% Pro: 9 9 67 0 67 9 9 9 9 0 59 17 0 0 9 % P
% Gln: 0 59 0 9 9 0 0 17 0 0 0 0 9 0 0 % Q
% Arg: 9 9 0 0 0 0 0 0 0 0 0 0 0 0 0 % R
% Ser: 9 0 9 9 9 0 9 59 0 0 9 50 0 9 9 % S
% Thr: 0 0 0 0 0 9 0 0 0 25 0 9 0 0 0 % T
% Val: 0 0 9 0 0 0 17 9 0 0 9 0 59 9 59 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 59 0 0 9 0 0 0 0 0 0 0 0 0 50 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _