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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HMGB2
All Species:
17.88
Human Site:
S115
Identified Species:
30.26
UniProt:
P26583
Number Species:
13
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P26583
NP_001124160.1
209
24034
S115
E
H
R
P
K
I
K
S
E
H
P
G
L
S
I
Chimpanzee
Pan troglodytes
Q9N1Q7
215
24747
P140
L
F
C
S
E
Y
R
P
K
I
K
G
E
H
P
Rhesus Macaque
Macaca mulatta
XP_001085665
321
35536
S229
E
H
R
P
K
I
K
S
E
H
P
G
L
S
I
Dog
Lupus familis
XP_543194
210
24144
S115
E
H
R
P
K
I
K
S
E
H
P
G
L
S
I
Cat
Felis silvestris
Mouse
Mus musculus
P30681
210
24143
I115
E
N
R
P
K
I
K
I
E
H
P
G
L
S
I
Rat
Rattus norvegicus
P52925
210
24140
S115
E
H
R
P
K
I
K
S
E
H
P
G
L
S
I
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001508702
215
24789
G115
E
Y
R
P
K
I
K
G
E
H
P
G
L
S
I
Chicken
Gallus gallus
P26584
207
23809
N115
E
H
R
P
K
I
K
N
D
H
P
G
L
S
I
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q24537
393
44916
A291
D
E
R
N
K
V
K
A
L
N
P
E
F
G
V
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q09390
235
27301
A155
D
K
R
P
E
I
Q
A
G
H
P
D
W
K
V
Sea Urchin
Strong. purpuratus
P40644
200
22815
S120
E
N
R
A
A
I
K
S
V
H
P
N
W
S
V
Poplar Tree
Populus trichocarpa
Maize
Zea mays
P27347
157
17127
S84
G
D
R
W
K
S
L
S
E
S
D
K
A
P
Y
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P11633
99
11557
N25
T
R
R
K
K
D
P
N
A
P
K
R
R
L
S
Red Bread Mold
Neurospora crassa
Q7S045
103
11590
L30
P
N
A
P
K
R
G
L
S
A
Y
M
F
F
A
Conservation
Percent
Protein Identity:
100
56.7
64.4
98.5
N.A.
96.6
98.5
N.A.
78.1
91.3
N.A.
N.A.
N.A.
27.9
N.A.
34
48.3
Protein Similarity:
100
66.5
64.4
99.5
N.A.
99
99
N.A.
86.9
96.1
N.A.
N.A.
N.A.
38.6
N.A.
50.2
61.7
P-Site Identity:
100
6.6
100
100
N.A.
86.6
100
N.A.
86.6
86.6
N.A.
N.A.
N.A.
26.6
N.A.
33.3
53.3
P-Site Similarity:
100
26.6
100
100
N.A.
93.3
100
N.A.
93.3
100
N.A.
N.A.
N.A.
60
N.A.
66.6
66.6
Percent
Protein Identity:
N.A.
33.9
N.A.
N.A.
23.4
26.7
Protein Similarity:
N.A.
46.4
N.A.
N.A.
32
33.9
P-Site Identity:
N.A.
26.6
N.A.
N.A.
13.3
13.3
P-Site Similarity:
N.A.
26.6
N.A.
N.A.
20
20
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
8
8
8
0
0
15
8
8
0
0
8
0
8
% A
% Cys:
0
0
8
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
15
8
0
0
0
8
0
0
8
0
8
8
0
0
0
% D
% Glu:
58
8
0
0
15
0
0
0
50
0
0
8
8
0
0
% E
% Phe:
0
8
0
0
0
0
0
0
0
0
0
0
15
8
0
% F
% Gly:
8
0
0
0
0
0
8
8
8
0
0
58
0
8
0
% G
% His:
0
36
0
0
0
0
0
0
0
65
0
0
0
8
0
% H
% Ile:
0
0
0
0
0
65
0
8
0
8
0
0
0
0
50
% I
% Lys:
0
8
0
8
79
0
65
0
8
0
15
8
0
8
0
% K
% Leu:
8
0
0
0
0
0
8
8
8
0
0
0
50
8
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
8
0
0
0
% M
% Asn:
0
22
0
8
0
0
0
15
0
8
0
8
0
0
0
% N
% Pro:
8
0
0
65
0
0
8
8
0
8
72
0
0
8
8
% P
% Gln:
0
0
0
0
0
0
8
0
0
0
0
0
0
0
0
% Q
% Arg:
0
8
86
0
0
8
8
0
0
0
0
8
8
0
0
% R
% Ser:
0
0
0
8
0
8
0
43
8
8
0
0
0
58
8
% S
% Thr:
8
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% T
% Val:
0
0
0
0
0
8
0
0
8
0
0
0
0
0
22
% V
% Trp:
0
0
0
8
0
0
0
0
0
0
0
0
15
0
0
% W
% Tyr:
0
8
0
0
0
8
0
0
0
0
8
0
0
0
8
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _