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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: HMGB2 All Species: 29.7
Human Site: S121 Identified Species: 50.26
UniProt: P26583 Number Species: 13
    Phosphosite Substitution
    Charge Score: -0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P26583 NP_001124160.1 209 24034 S121 K S E H P G L S I G D T A K K
Chimpanzee Pan troglodytes Q9N1Q7 215 24747 H146 R P K I K G E H P G L S I D D
Rhesus Macaque Macaca mulatta XP_001085665 321 35536 S235 K S E H P G L S I G D T A K K
Dog Lupus familis XP_543194 210 24144 S121 K S E H P G L S I G D T A K K
Cat Felis silvestris
Mouse Mus musculus P30681 210 24143 S121 K I E H P G L S I G D T A K K
Rat Rattus norvegicus P52925 210 24140 S121 K S E H P G L S I G D T A K K
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001508702 215 24789 S121 K G E H P G L S I G D V A K K
Chicken Gallus gallus P26584 207 23809 S121 K N D H P G L S I G D T A K K
Frog Xenopus laevis
Zebra Danio Brachydanio rerio
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q24537 393 44916 G297 K A L N P E F G V G D I A K E
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans Q09390 235 27301 K161 Q A G H P D W K V G Q V A Q E
Sea Urchin Strong. purpuratus P40644 200 22815 S126 K S V H P N W S V G D I A K E
Poplar Tree Populus trichocarpa
Maize Zea mays P27347 157 17127 P90 L S E S D K A P Y V A K A N K
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P11633 99 11557 L31 P N A P K R R L S A Y M F F A
Red Bread Mold Neurospora crassa Q7S045 103 11590 F36 G L S A Y M F F A N E Q R E N
Conservation
Percent
Protein Identity: 100 56.7 64.4 98.5 N.A. 96.6 98.5 N.A. 78.1 91.3 N.A. N.A. N.A. 27.9 N.A. 34 48.3
Protein Similarity: 100 66.5 64.4 99.5 N.A. 99 99 N.A. 86.9 96.1 N.A. N.A. N.A. 38.6 N.A. 50.2 61.7
P-Site Identity: 100 13.3 100 100 N.A. 93.3 100 N.A. 86.6 86.6 N.A. N.A. N.A. 40 N.A. 26.6 60
P-Site Similarity: 100 33.3 100 100 N.A. 93.3 100 N.A. 86.6 100 N.A. N.A. N.A. 66.6 N.A. 60 73.3
Percent
Protein Identity: N.A. 33.9 N.A. N.A. 23.4 26.7
Protein Similarity: N.A. 46.4 N.A. N.A. 32 33.9
P-Site Identity: N.A. 26.6 N.A. N.A. 0 0
P-Site Similarity: N.A. 26.6 N.A. N.A. 6.6 13.3
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 15 8 8 0 0 8 0 8 8 8 0 79 0 8 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 8 0 8 8 0 0 0 0 65 0 0 8 8 % D
% Glu: 0 0 50 0 0 8 8 0 0 0 8 0 0 8 22 % E
% Phe: 0 0 0 0 0 0 15 8 0 0 0 0 8 8 0 % F
% Gly: 8 8 8 0 0 58 0 8 0 79 0 0 0 0 0 % G
% His: 0 0 0 65 0 0 0 8 0 0 0 0 0 0 0 % H
% Ile: 0 8 0 8 0 0 0 0 50 0 0 15 8 0 0 % I
% Lys: 65 0 8 0 15 8 0 8 0 0 0 8 0 65 58 % K
% Leu: 8 8 8 0 0 0 50 8 0 0 8 0 0 0 0 % L
% Met: 0 0 0 0 0 8 0 0 0 0 0 8 0 0 0 % M
% Asn: 0 15 0 8 0 8 0 0 0 8 0 0 0 8 8 % N
% Pro: 8 8 0 8 72 0 0 8 8 0 0 0 0 0 0 % P
% Gln: 8 0 0 0 0 0 0 0 0 0 8 8 0 8 0 % Q
% Arg: 8 0 0 0 0 8 8 0 0 0 0 0 8 0 0 % R
% Ser: 0 43 8 8 0 0 0 58 8 0 0 8 0 0 0 % S
% Thr: 0 0 0 0 0 0 0 0 0 0 0 43 0 0 0 % T
% Val: 0 0 8 0 0 0 0 0 22 8 0 15 0 0 0 % V
% Trp: 0 0 0 0 0 0 15 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 8 0 0 0 8 0 8 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _