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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HMGB2
All Species:
29.7
Human Site:
S121
Identified Species:
50.26
UniProt:
P26583
Number Species:
13
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P26583
NP_001124160.1
209
24034
S121
K
S
E
H
P
G
L
S
I
G
D
T
A
K
K
Chimpanzee
Pan troglodytes
Q9N1Q7
215
24747
H146
R
P
K
I
K
G
E
H
P
G
L
S
I
D
D
Rhesus Macaque
Macaca mulatta
XP_001085665
321
35536
S235
K
S
E
H
P
G
L
S
I
G
D
T
A
K
K
Dog
Lupus familis
XP_543194
210
24144
S121
K
S
E
H
P
G
L
S
I
G
D
T
A
K
K
Cat
Felis silvestris
Mouse
Mus musculus
P30681
210
24143
S121
K
I
E
H
P
G
L
S
I
G
D
T
A
K
K
Rat
Rattus norvegicus
P52925
210
24140
S121
K
S
E
H
P
G
L
S
I
G
D
T
A
K
K
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001508702
215
24789
S121
K
G
E
H
P
G
L
S
I
G
D
V
A
K
K
Chicken
Gallus gallus
P26584
207
23809
S121
K
N
D
H
P
G
L
S
I
G
D
T
A
K
K
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q24537
393
44916
G297
K
A
L
N
P
E
F
G
V
G
D
I
A
K
E
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q09390
235
27301
K161
Q
A
G
H
P
D
W
K
V
G
Q
V
A
Q
E
Sea Urchin
Strong. purpuratus
P40644
200
22815
S126
K
S
V
H
P
N
W
S
V
G
D
I
A
K
E
Poplar Tree
Populus trichocarpa
Maize
Zea mays
P27347
157
17127
P90
L
S
E
S
D
K
A
P
Y
V
A
K
A
N
K
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P11633
99
11557
L31
P
N
A
P
K
R
R
L
S
A
Y
M
F
F
A
Red Bread Mold
Neurospora crassa
Q7S045
103
11590
F36
G
L
S
A
Y
M
F
F
A
N
E
Q
R
E
N
Conservation
Percent
Protein Identity:
100
56.7
64.4
98.5
N.A.
96.6
98.5
N.A.
78.1
91.3
N.A.
N.A.
N.A.
27.9
N.A.
34
48.3
Protein Similarity:
100
66.5
64.4
99.5
N.A.
99
99
N.A.
86.9
96.1
N.A.
N.A.
N.A.
38.6
N.A.
50.2
61.7
P-Site Identity:
100
13.3
100
100
N.A.
93.3
100
N.A.
86.6
86.6
N.A.
N.A.
N.A.
40
N.A.
26.6
60
P-Site Similarity:
100
33.3
100
100
N.A.
93.3
100
N.A.
86.6
100
N.A.
N.A.
N.A.
66.6
N.A.
60
73.3
Percent
Protein Identity:
N.A.
33.9
N.A.
N.A.
23.4
26.7
Protein Similarity:
N.A.
46.4
N.A.
N.A.
32
33.9
P-Site Identity:
N.A.
26.6
N.A.
N.A.
0
0
P-Site Similarity:
N.A.
26.6
N.A.
N.A.
6.6
13.3
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
15
8
8
0
0
8
0
8
8
8
0
79
0
8
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
8
0
8
8
0
0
0
0
65
0
0
8
8
% D
% Glu:
0
0
50
0
0
8
8
0
0
0
8
0
0
8
22
% E
% Phe:
0
0
0
0
0
0
15
8
0
0
0
0
8
8
0
% F
% Gly:
8
8
8
0
0
58
0
8
0
79
0
0
0
0
0
% G
% His:
0
0
0
65
0
0
0
8
0
0
0
0
0
0
0
% H
% Ile:
0
8
0
8
0
0
0
0
50
0
0
15
8
0
0
% I
% Lys:
65
0
8
0
15
8
0
8
0
0
0
8
0
65
58
% K
% Leu:
8
8
8
0
0
0
50
8
0
0
8
0
0
0
0
% L
% Met:
0
0
0
0
0
8
0
0
0
0
0
8
0
0
0
% M
% Asn:
0
15
0
8
0
8
0
0
0
8
0
0
0
8
8
% N
% Pro:
8
8
0
8
72
0
0
8
8
0
0
0
0
0
0
% P
% Gln:
8
0
0
0
0
0
0
0
0
0
8
8
0
8
0
% Q
% Arg:
8
0
0
0
0
8
8
0
0
0
0
0
8
0
0
% R
% Ser:
0
43
8
8
0
0
0
58
8
0
0
8
0
0
0
% S
% Thr:
0
0
0
0
0
0
0
0
0
0
0
43
0
0
0
% T
% Val:
0
0
8
0
0
0
0
0
22
8
0
15
0
0
0
% V
% Trp:
0
0
0
0
0
0
15
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
8
0
0
0
8
0
8
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _