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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: VARS All Species: 4.55
Human Site: S124 Identified Species: 6.25
UniProt: P26640 Number Species: 16
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P26640 NP_006286.1 1264 140476 S124 P A L G L R S S A Q D P Q A V
Chimpanzee Pan troglodytes XP_001160008 1264 140384 S124 P A L G L R S S A Q D P Q A V
Rhesus Macaque Macaca mulatta Q5TM74 1064 118624 P78 E S I K A W S P K E V V L Y E
Dog Lupus familis XP_538837 1256 139671 A124 P A L G L R S A A Q D P Q A A
Cat Felis silvestris
Mouse Mus musculus Q9Z1Q9 1263 140197 P124 P A L G L R G P G Q D P Q A A
Rat Rattus norvegicus Q04462 1264 140350 P124 P A L G L R G P G Q D P Q A A
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001520676 985 109386
Chicken Gallus gallus
Frog Xenopus laevis NP_001088439 1243 140617 L111 S Q N N E R S L L E L Q K I L
Zebra Danio Brachydanio rerio XP_682807 1111 123867 G110 L P Q I L G C G S C L S K S D
Tiger Blowfish Takifugu rubipres P49696 1217 138200 L109 A V A M A V L L P F K Y V L E
Fruit Fly Dros. melanogaster NP_524838 1049 118236 R64 K K E K P E K R T K E V K E A
Honey Bee Apis mellifera XP_395202 1043 121057 I58 I K E K N E K I E K K K E S K
Nematode Worm Caenorhab. elegans Q9U1Q4 1050 118902 D65 V E A A E P V D Q T P T G Q R
Sea Urchin Strong. purpuratus XP_001200958 1119 126755 I114 R R E K I D E I Q R D G E E A
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana P93736 1108 125908 K108 K S A K K S S K R D A S E E N
Baker's Yeast Sacchar. cerevisiae P07806 1104 125751 A108 N A A A T T G A S Q K K P K K
Red Bread Mold Neurospora crassa P28350 1093 123334 E106 A A Q S A P K E K K E K T P A
Conservation
Percent
Protein Identity: 100 99.5 43.4 92.8 N.A. 93.4 93.4 N.A. 63 N.A. 65.3 45 63.8 50.9 49.1 44.9 44.4
Protein Similarity: 100 99.8 56 95.6 N.A. 96.4 96.3 N.A. 69.8 N.A. 78 58.8 76.8 63.1 63.4 59.5 59.6
P-Site Identity: 100 100 6.6 86.6 N.A. 73.3 73.3 N.A. 0 N.A. 13.3 6.6 0 0 0 0 6.6
P-Site Similarity: 100 100 26.6 93.3 N.A. 73.3 73.3 N.A. 0 N.A. 33.3 26.6 0 20 20 0 26.6
Percent
Protein Identity: N.A. N.A. N.A. 41.6 42.6 40.3
Protein Similarity: N.A. N.A. N.A. 58.3 60.1 56
P-Site Identity: N.A. N.A. N.A. 6.6 13.3 6.6
P-Site Similarity: N.A. N.A. N.A. 20 26.6 20
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 12 42 24 12 18 0 0 12 18 0 6 0 0 30 36 % A
% Cys: 0 0 0 0 0 0 6 0 0 6 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 6 0 6 0 6 36 0 0 0 6 % D
% Glu: 6 6 18 0 12 12 6 6 6 12 12 0 18 18 12 % E
% Phe: 0 0 0 0 0 0 0 0 0 6 0 0 0 0 0 % F
% Gly: 0 0 0 30 0 6 18 6 12 0 0 6 6 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 6 0 6 6 6 0 0 12 0 0 0 0 0 6 0 % I
% Lys: 12 12 0 30 6 0 18 6 12 18 18 18 18 6 12 % K
% Leu: 6 0 30 0 36 0 6 12 6 0 12 0 6 6 6 % L
% Met: 0 0 0 6 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 6 0 6 6 6 0 0 0 0 0 0 0 0 0 6 % N
% Pro: 30 6 0 0 6 12 0 18 6 0 6 30 6 6 0 % P
% Gln: 0 6 12 0 0 0 0 0 12 36 0 6 30 6 0 % Q
% Arg: 6 6 0 0 0 36 0 6 6 6 0 0 0 0 6 % R
% Ser: 6 12 0 6 0 6 36 12 12 0 0 12 0 12 0 % S
% Thr: 0 0 0 0 6 6 0 0 6 6 0 6 6 0 0 % T
% Val: 6 6 0 0 0 6 6 0 0 0 6 12 6 0 12 % V
% Trp: 0 0 0 0 0 6 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 6 0 6 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _