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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: VARS All Species: 11.82
Human Site: S140 Identified Species: 16.25
UniProt: P26640 Number Species: 16
    Phosphosite Substitution
    Charge Score: -0.06
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P26640 NP_006286.1 1264 140476 S140 G A L G R A L S P L E E W L R
Chimpanzee Pan troglodytes XP_001160008 1264 140384 S140 G A L G R A L S P L E E W L R
Rhesus Macaque Macaca mulatta Q5TM74 1064 118624 K93 I P T K P G E K K D V S G P L
Dog Lupus familis XP_538837 1256 139671 S140 G A L G R A L S P L E E W L R
Cat Felis silvestris
Mouse Mus musculus Q9Z1Q9 1263 140197 N140 G A L G K A L N P L E D W L R
Rat Rattus norvegicus Q04462 1264 140350 N140 G A L G K A L N P L E E W L R
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001520676 985 109386 S15 P H P E S F P S L R A L I A A
Chicken Gallus gallus
Frog Xenopus laevis NP_001088439 1243 140617 K126 D N L D C Y L K L R T Y L V G
Zebra Danio Brachydanio rerio XP_682807 1111 123867 P125 D L T H G S V P G Y N S Q R V
Tiger Blowfish Takifugu rubipres P49696 1217 138200 M124 P S D R N V L M N V T R W F T
Fruit Fly Dros. melanogaster NP_524838 1049 118236 A79 A V Y T A Q T A P G E K K D L
Honey Bee Apis mellifera XP_395202 1043 121057 N73 E L A I Y T I N T L E G D K K
Nematode Worm Caenorhab. elegans Q9U1Q4 1050 118902 P80 K K I D G E I P A A Y F P G Y
Sea Urchin Strong. purpuratus XP_001200958 1119 126755 Q131 S R R Q G A G Q K S W S K K E
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana P93736 1108 125908 T124 E D F V D P E T P L G E R K R
Baker's Yeast Sacchar. cerevisiae P07806 1104 125751 E124 K E V E P I P E F I D K T V P
Red Bread Mold Neurospora crassa P28350 1093 123334 T121 L P P Y E D S T P A G E K K V
Conservation
Percent
Protein Identity: 100 99.5 43.4 92.8 N.A. 93.4 93.4 N.A. 63 N.A. 65.3 45 63.8 50.9 49.1 44.9 44.4
Protein Similarity: 100 99.8 56 95.6 N.A. 96.4 96.3 N.A. 69.8 N.A. 78 58.8 76.8 63.1 63.4 59.5 59.6
P-Site Identity: 100 100 0 100 N.A. 80 86.6 N.A. 6.6 N.A. 13.3 0 13.3 13.3 13.3 0 6.6
P-Site Similarity: 100 100 0 100 N.A. 100 100 N.A. 6.6 N.A. 20 13.3 26.6 26.6 33.3 13.3 6.6
Percent
Protein Identity: N.A. N.A. N.A. 41.6 42.6 40.3
Protein Similarity: N.A. N.A. N.A. 58.3 60.1 56
P-Site Identity: N.A. N.A. N.A. 26.6 0 13.3
P-Site Similarity: N.A. N.A. N.A. 33.3 33.3 20
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 6 30 6 0 6 36 0 6 6 12 6 0 0 6 6 % A
% Cys: 0 0 0 0 6 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 12 6 6 12 6 6 0 0 0 6 6 6 6 6 0 % D
% Glu: 12 6 0 12 6 6 12 6 0 0 42 36 0 0 6 % E
% Phe: 0 0 6 0 0 6 0 0 6 0 0 6 0 6 0 % F
% Gly: 30 0 0 30 18 6 6 0 6 6 12 6 6 6 6 % G
% His: 0 6 0 6 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 6 0 6 6 0 6 12 0 0 6 0 0 6 0 0 % I
% Lys: 12 6 0 6 12 0 0 12 12 0 0 12 18 24 6 % K
% Leu: 6 12 36 0 0 0 42 0 12 42 0 6 6 30 12 % L
% Met: 0 0 0 0 0 0 0 6 0 0 0 0 0 0 0 % M
% Asn: 0 6 0 0 6 0 0 18 6 0 6 0 0 0 0 % N
% Pro: 12 12 12 0 12 6 12 12 48 0 0 0 6 6 6 % P
% Gln: 0 0 0 6 0 6 0 6 0 0 0 0 6 0 0 % Q
% Arg: 0 6 6 6 18 0 0 0 0 12 0 6 6 6 36 % R
% Ser: 6 6 0 0 6 6 6 24 0 6 0 18 0 0 0 % S
% Thr: 0 0 12 6 0 6 6 12 6 0 12 0 6 0 6 % T
% Val: 0 6 6 6 0 6 6 0 0 6 6 0 0 12 12 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 6 0 36 0 0 % W
% Tyr: 0 0 6 6 6 6 0 0 0 6 6 6 0 0 6 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _