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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: VARS All Species: 29.7
Human Site: S436 Identified Species: 40.83
UniProt: P26640 Number Species: 16
    Phosphosite Substitution
    Charge Score: 0.06
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P26640 NP_006286.1 1264 140476 S436 H Q L K K L G S S L D W D R A
Chimpanzee Pan troglodytes XP_001160008 1264 140384 S436 H Q L K K L G S S L D W D R A
Rhesus Macaque Macaca mulatta Q5TM74 1064 118624 P340 V V V G T T R P E T L P G D V
Dog Lupus familis XP_538837 1256 139671 S436 H Q L K K L G S S L D W N R A
Cat Felis silvestris
Mouse Mus musculus Q9Z1Q9 1263 140197 S435 H Q L K K L G S S L D W D R A
Rat Rattus norvegicus Q04462 1264 140350 S436 H Q L K K L G S S L D W D R A
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001520676 985 109386 K262 P K A E K K E K R D P G V I T
Chicken Gallus gallus
Frog Xenopus laevis NP_001088439 1243 140617 S417 H Q L R I L G S S L D W D R A
Zebra Danio Brachydanio rerio XP_682807 1111 123867 L372 G C L D F G D L V E G S T K A
Tiger Blowfish Takifugu rubipres P49696 1217 138200 S385 H Q L K K L G S S L D W D R A
Fruit Fly Dros. melanogaster NP_524838 1049 118236 A326 S D E E I I V A T T R I E T M
Honey Bee Apis mellifera XP_395202 1043 121057 I320 I D F E K K I I V A T T R I E
Nematode Worm Caenorhab. elegans Q9U1Q4 1050 118902 G327 E T M L G D S G V A V H P D D
Sea Urchin Strong. purpuratus XP_001200958 1119 126755 E385 T Y F A Y P I E S S D A E I V
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana P93736 1108 125908 T371 V A T T R V E T M L G D T A I
Baker's Yeast Sacchar. cerevisiae P07806 1104 125751 D372 A Y P V I G S D E K L I I A T
Red Bread Mold Neurospora crassa P28350 1093 123334 T368 E E T I E V A T T R P E T M L
Conservation
Percent
Protein Identity: 100 99.5 43.4 92.8 N.A. 93.4 93.4 N.A. 63 N.A. 65.3 45 63.8 50.9 49.1 44.9 44.4
Protein Similarity: 100 99.8 56 95.6 N.A. 96.4 96.3 N.A. 69.8 N.A. 78 58.8 76.8 63.1 63.4 59.5 59.6
P-Site Identity: 100 100 0 93.3 N.A. 100 100 N.A. 6.6 N.A. 86.6 13.3 100 0 6.6 0 13.3
P-Site Similarity: 100 100 6.6 100 N.A. 100 100 N.A. 20 N.A. 93.3 20 100 33.3 13.3 6.6 20
Percent
Protein Identity: N.A. N.A. N.A. 41.6 42.6 40.3
Protein Similarity: N.A. N.A. N.A. 58.3 60.1 56
P-Site Identity: N.A. N.A. N.A. 6.6 0 0
P-Site Similarity: N.A. N.A. N.A. 26.6 0 33.3
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 6 6 6 6 0 0 6 6 0 12 0 6 0 12 48 % A
% Cys: 0 6 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 12 0 6 0 6 6 6 0 6 48 6 36 12 6 % D
% Glu: 12 6 6 18 6 0 12 6 12 6 0 6 12 0 6 % E
% Phe: 0 0 12 0 6 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 6 0 0 6 6 12 42 6 0 0 12 6 6 0 0 % G
% His: 42 0 0 0 0 0 0 0 0 0 0 6 0 0 0 % H
% Ile: 6 0 0 6 18 6 12 6 0 0 0 12 6 18 6 % I
% Lys: 0 6 0 36 48 12 0 6 0 6 0 0 0 6 0 % K
% Leu: 0 0 48 6 0 42 0 6 0 48 12 0 0 0 6 % L
% Met: 0 0 6 0 0 0 0 0 6 0 0 0 0 6 6 % M
% Asn: 0 0 0 0 0 0 0 0 0 0 0 0 6 0 0 % N
% Pro: 6 0 6 0 0 6 0 6 0 0 12 6 6 0 0 % P
% Gln: 0 42 0 0 0 0 0 0 0 0 0 0 0 0 0 % Q
% Arg: 0 0 0 6 6 0 6 0 6 6 6 0 6 42 0 % R
% Ser: 6 0 0 0 0 0 12 42 48 6 0 6 0 0 0 % S
% Thr: 6 6 12 6 6 6 0 12 12 12 6 6 18 6 12 % T
% Val: 12 6 6 6 0 12 6 0 18 0 6 0 6 0 12 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 42 0 0 0 % W
% Tyr: 0 12 0 0 6 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _