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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: VARS All Species: 15.76
Human Site: S502 Identified Species: 21.67
UniProt: P26640 Number Species: 16
    Phosphosite Substitution
    Charge Score: -0.06
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P26640 NP_006286.1 1264 140476 S502 L T G R T L L S V P G Y K E K
Chimpanzee Pan troglodytes XP_001160008 1264 140384 S502 L T G R T L L S V P G Y K E K
Rhesus Macaque Macaca mulatta Q5TM74 1064 118624 G406 S P A D A E M G A R H G L S P
Dog Lupus familis XP_538837 1256 139671 S502 L T G R T L L S V P G Y K E K
Cat Felis silvestris
Mouse Mus musculus Q9Z1Q9 1263 140197 P501 L T G R T L L P V P G Y K E K
Rat Rattus norvegicus Q04462 1264 140350 S502 L T G R T L L S V P G Y K E K
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001520676 985 109386 M328 P N P R G V F M M C I P P P N
Chicken Gallus gallus
Frog Xenopus laevis NP_001088439 1243 140617 P483 L S G R T L L P V P G Y K Q G
Zebra Danio Brachydanio rerio XP_682807 1111 123867 A438 G A V K I T P A H D H N D Y E
Tiger Blowfish Takifugu rubipres P49696 1217 138200 P451 L S G R T L L P V P G Y K E K
Fruit Fly Dros. melanogaster NP_524838 1049 118236 D392 T P A H D P N D Y E V G K R C
Honey Bee Apis mellifera XP_395202 1043 121057 P386 K I T P A H D P N D Y E V G K
Nematode Worm Caenorhab. elegans Q9U1Q4 1050 118902 F393 G I R Q N L P F H N C I T D D
Sea Urchin Strong. purpuratus XP_001200958 1119 126755 K451 A Y G T G A V K I T P A H D Y
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana P93736 1108 125908 K437 P N D C E V G K R H K L E F I
Baker's Yeast Sacchar. cerevisiae P07806 1104 125751 T438 G T G A V K I T P A H D Q N D
Red Bread Mold Neurospora crassa P28350 1093 123334 Y434 P A H D F N D Y Q L G Q R H N
Conservation
Percent
Protein Identity: 100 99.5 43.4 92.8 N.A. 93.4 93.4 N.A. 63 N.A. 65.3 45 63.8 50.9 49.1 44.9 44.4
Protein Similarity: 100 99.8 56 95.6 N.A. 96.4 96.3 N.A. 69.8 N.A. 78 58.8 76.8 63.1 63.4 59.5 59.6
P-Site Identity: 100 100 0 100 N.A. 93.3 100 N.A. 6.6 N.A. 73.3 0 86.6 6.6 6.6 6.6 6.6
P-Site Similarity: 100 100 6.6 100 N.A. 93.3 100 N.A. 20 N.A. 86.6 20 93.3 6.6 6.6 20 26.6
Percent
Protein Identity: N.A. N.A. N.A. 41.6 42.6 40.3
Protein Similarity: N.A. N.A. N.A. 58.3 60.1 56
P-Site Identity: N.A. N.A. N.A. 0 13.3 6.6
P-Site Similarity: N.A. N.A. N.A. 13.3 33.3 13.3
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 6 12 12 6 12 6 0 6 6 6 0 6 0 0 0 % A
% Cys: 0 0 0 6 0 0 0 0 0 6 6 0 0 0 6 % C
% Asp: 0 0 6 12 6 0 12 6 0 12 0 6 6 12 12 % D
% Glu: 0 0 0 0 6 6 0 0 0 6 0 6 6 36 6 % E
% Phe: 0 0 0 0 6 0 6 6 0 0 0 0 0 6 0 % F
% Gly: 18 0 53 0 12 0 6 6 0 0 48 12 0 6 6 % G
% His: 0 0 6 6 0 6 0 0 12 6 18 0 6 6 0 % H
% Ile: 0 12 0 0 6 0 6 0 6 0 6 6 0 0 6 % I
% Lys: 6 0 0 6 0 6 0 12 0 0 6 0 48 0 42 % K
% Leu: 42 0 0 0 0 48 42 0 0 6 0 6 6 0 0 % L
% Met: 0 0 0 0 0 0 6 6 6 0 0 0 0 0 0 % M
% Asn: 0 12 0 0 6 6 6 0 6 6 0 6 0 6 12 % N
% Pro: 18 12 6 6 0 6 12 24 6 42 6 6 6 6 6 % P
% Gln: 0 0 0 6 0 0 0 0 6 0 0 6 6 6 0 % Q
% Arg: 0 0 6 48 0 0 0 0 6 6 0 0 6 6 0 % R
% Ser: 6 12 0 0 0 0 0 24 0 0 0 0 0 6 0 % S
% Thr: 6 36 6 6 42 6 0 6 0 6 0 0 6 0 0 % T
% Val: 0 0 6 0 6 12 6 0 42 0 6 0 6 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 6 0 0 0 0 0 6 6 0 6 42 0 6 6 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _