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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: VARS All Species: 29.39
Human Site: S892 Identified Species: 40.42
UniProt: P26640 Number Species: 16
    Phosphosite Substitution
    Charge Score: -0.06
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P26640 NP_006286.1 1264 140476 S892 L H N Q L L N S N L D P S E V
Chimpanzee Pan troglodytes XP_001160008 1264 140384 S892 L H D Q L L N S N L D P S E V
Rhesus Macaque Macaca mulatta Q5TM74 1064 118624 R755 N K I W N A L R F I L N A L G
Dog Lupus familis XP_538837 1256 139671 S892 L H D Q L L N S N L D P S E V
Cat Felis silvestris
Mouse Mus musculus Q9Z1Q9 1263 140197 S891 L Y D Q L L N S N L D P S E V
Rat Rattus norvegicus Q04462 1264 140350 S892 L H D Q L L N S N L D P S E V
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001520676 985 109386 A676 Y V R C E D M A R A A S A A V
Chicken Gallus gallus
Frog Xenopus laevis NP_001088439 1243 140617 S871 L H K Q L L E S N L D P A E L
Zebra Danio Brachydanio rerio XP_682807 1111 123867 I786 I N L D V N R I L G Y R H F C
Tiger Blowfish Takifugu rubipres P49696 1217 138200 T839 L H A Q L M D T N L D P L E V
Fruit Fly Dros. melanogaster NP_524838 1049 118236 F740 N R V L G Y R F F C N K L W N
Honey Bee Apis mellifera XP_395202 1043 121057 F734 L R V Q G Y R F F C N K I W N
Nematode Worm Caenorhab. elegans Q9U1Q4 1050 118902 L741 W Q V V R F A L A R I S D K P
Sea Urchin Strong. purpuratus XP_001200958 1119 126755 Y802 N V G Q V L E Y R H F C N K I
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana P93736 1108 125908 A789 W C N K L W N A V R F A M M K
Baker's Yeast Sacchar. cerevisiae P07806 1104 125751 Y787 D I L R V E G Y R K F C N K I
Red Bread Mold Neurospora crassa P28350 1093 123334 W784 R R F C N K I W Q A S K Y V L
Conservation
Percent
Protein Identity: 100 99.5 43.4 92.8 N.A. 93.4 93.4 N.A. 63 N.A. 65.3 45 63.8 50.9 49.1 44.9 44.4
Protein Similarity: 100 99.8 56 95.6 N.A. 96.4 96.3 N.A. 69.8 N.A. 78 58.8 76.8 63.1 63.4 59.5 59.6
P-Site Identity: 100 93.3 0 93.3 N.A. 86.6 93.3 N.A. 6.6 N.A. 73.3 0 66.6 0 13.3 0 13.3
P-Site Similarity: 100 100 13.3 100 N.A. 100 100 N.A. 20 N.A. 86.6 20 86.6 6.6 20 6.6 40
Percent
Protein Identity: N.A. N.A. N.A. 41.6 42.6 40.3
Protein Similarity: N.A. N.A. N.A. 58.3 60.1 56
P-Site Identity: N.A. N.A. N.A. 20 0 0
P-Site Similarity: N.A. N.A. N.A. 33.3 33.3 6.6
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 6 0 0 6 6 12 6 12 6 6 18 6 0 % A
% Cys: 0 6 0 12 0 0 0 0 0 12 0 12 0 0 6 % C
% Asp: 6 0 24 6 0 6 6 0 0 0 42 0 6 0 0 % D
% Glu: 0 0 0 0 6 6 12 0 0 0 0 0 0 42 0 % E
% Phe: 0 0 6 0 0 6 0 12 18 0 18 0 0 6 0 % F
% Gly: 0 0 6 0 12 0 6 0 0 6 0 0 0 0 6 % G
% His: 0 36 0 0 0 0 0 0 0 6 0 0 6 0 0 % H
% Ile: 6 6 6 0 0 0 6 6 0 6 6 0 6 0 12 % I
% Lys: 0 6 6 6 0 6 0 0 0 6 0 18 0 18 6 % K
% Leu: 48 0 12 6 48 42 6 6 6 42 6 0 12 6 12 % L
% Met: 0 0 0 0 0 6 6 0 0 0 0 0 6 6 0 % M
% Asn: 18 6 12 0 12 6 36 0 42 0 12 6 12 0 12 % N
% Pro: 0 0 0 0 0 0 0 0 0 0 0 42 0 0 6 % P
% Gln: 0 6 0 53 0 0 0 0 6 0 0 0 0 0 0 % Q
% Arg: 6 18 6 6 6 0 18 6 18 12 0 6 0 0 0 % R
% Ser: 0 0 0 0 0 0 0 36 0 0 6 12 30 0 0 % S
% Thr: 0 0 0 0 0 0 0 6 0 0 0 0 0 0 0 % T
% Val: 0 12 18 6 18 0 0 0 6 0 0 0 0 6 42 % V
% Trp: 12 0 0 6 0 6 0 6 0 0 0 0 0 12 0 % W
% Tyr: 6 6 0 0 0 12 0 12 0 0 6 0 6 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _