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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: VARS All Species: 23.03
Human Site: S981 Identified Species: 31.67
UniProt: P26640 Number Species: 16
    Phosphosite Substitution
    Charge Score: -0.13
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P26640 NP_006286.1 1264 140476 S981 S Q P G G H E S L V D R W I R
Chimpanzee Pan troglodytes XP_001160008 1264 140384 S981 S Q P G G H E S L V D R W I R
Rhesus Macaque Macaca mulatta Q5TM74 1064 118624 P837 L R H S P C P P G P P Q V L F
Dog Lupus familis XP_538837 1256 139671 S981 S E P G G H E S L V D R W I R
Cat Felis silvestris
Mouse Mus musculus Q9Z1Q9 1263 140197 S980 S K P E G H E S L V D R W I R
Rat Rattus norvegicus Q04462 1264 140350 S981 S K P E G H E S L V D R W I R
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001520676 985 109386 A758 Q E A R E K A A Q Q F G V A P
Chicken Gallus gallus
Frog Xenopus laevis NP_001088439 1243 140617 S960 A G A C G Q E S L A D R W I L
Zebra Danio Brachydanio rerio XP_682807 1111 123867 V868 W L Y E L C D V Y L E C V K P
Tiger Blowfish Takifugu rubipres P49696 1217 138200 S928 S P A E R E E S V S D R W I L
Fruit Fly Dros. melanogaster NP_524838 1049 118236 L822 C D V Y L E C L K P I F Q S G
Honey Bee Apis mellifera XP_395202 1043 121057 K816 D I Y L E Y L K P V F Q S D D
Nematode Worm Caenorhab. elegans Q9U1Q4 1050 118902 R823 Y G D N T T L R Q V A I S V L
Sea Urchin Strong. purpuratus XP_001200958 1119 126755 C885 L C D V Y L E C I K E P L N K
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana P93736 1108 125908 A874 A G D N P T F A S E R A H A Q
Baker's Yeast Sacchar. cerevisiae P07806 1104 125751 S870 C D V Y I E N S K Y L I Q E G
Red Bread Mold Neurospora crassa P28350 1093 123334 G866 S K G I L S D G T P E E Q Q S
Conservation
Percent
Protein Identity: 100 99.5 43.4 92.8 N.A. 93.4 93.4 N.A. 63 N.A. 65.3 45 63.8 50.9 49.1 44.9 44.4
Protein Similarity: 100 99.8 56 95.6 N.A. 96.4 96.3 N.A. 69.8 N.A. 78 58.8 76.8 63.1 63.4 59.5 59.6
P-Site Identity: 100 100 0 93.3 N.A. 86.6 86.6 N.A. 0 N.A. 53.3 0 46.6 0 6.6 6.6 6.6
P-Site Similarity: 100 100 20 100 N.A. 93.3 93.3 N.A. 13.3 N.A. 60 20 53.3 0 20 13.3 26.6
Percent
Protein Identity: N.A. N.A. N.A. 41.6 42.6 40.3
Protein Similarity: N.A. N.A. N.A. 58.3 60.1 56
P-Site Identity: N.A. N.A. N.A. 0 6.6 6.6
P-Site Similarity: N.A. N.A. N.A. 20 6.6 26.6
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 12 0 18 0 0 0 6 12 0 6 6 6 0 12 0 % A
% Cys: 12 6 0 6 0 12 6 6 0 0 0 6 0 0 0 % C
% Asp: 6 12 18 0 0 0 12 0 0 0 42 0 0 6 6 % D
% Glu: 0 12 0 24 12 18 48 0 0 6 18 6 0 6 0 % E
% Phe: 0 0 0 0 0 0 6 0 0 0 12 6 0 0 6 % F
% Gly: 0 18 6 18 36 0 0 6 6 0 0 6 0 0 12 % G
% His: 0 0 6 0 0 30 0 0 0 0 0 0 6 0 0 % H
% Ile: 0 6 0 6 6 0 0 0 6 0 6 12 0 42 0 % I
% Lys: 0 18 0 0 0 6 0 6 12 6 0 0 0 6 6 % K
% Leu: 12 6 0 6 18 6 12 6 36 6 6 0 6 6 18 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 12 0 0 6 0 0 0 0 0 0 6 0 % N
% Pro: 0 6 30 0 12 0 6 6 6 18 6 6 0 0 12 % P
% Gln: 6 12 0 0 0 6 0 0 12 6 0 12 18 6 6 % Q
% Arg: 0 6 0 6 6 0 0 6 0 0 6 42 0 0 30 % R
% Ser: 42 0 0 6 0 6 0 48 6 6 0 0 12 6 6 % S
% Thr: 0 0 0 0 6 12 0 0 6 0 0 0 0 0 0 % T
% Val: 0 0 12 6 0 0 0 6 6 42 0 0 18 6 0 % V
% Trp: 6 0 0 0 0 0 0 0 0 0 0 0 42 0 0 % W
% Tyr: 6 0 12 12 6 6 0 0 6 6 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _