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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: VARS All Species: 27.88
Human Site: T480 Identified Species: 38.33
UniProt: P26640 Number Species: 16
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P26640 NP_006286.1 1264 140476 T480 R L V N W S C T L N S A I S D
Chimpanzee Pan troglodytes XP_001160008 1264 140384 T480 R L V N W S C T L N S A I S D
Rhesus Macaque Macaca mulatta Q5TM74 1064 118624 Q384 L I T D Y A V Q P H V G T G A
Dog Lupus familis XP_538837 1256 139671 T480 R L V N W S C T L N S A I S D
Cat Felis silvestris
Mouse Mus musculus Q9Z1Q9 1263 140197 T479 R L V N W S C T L N S A I S D
Rat Rattus norvegicus Q04462 1264 140350 T480 R L V N W S C T L N S A I S D
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001520676 985 109386 Q306 W Y P W W E S Q G F F K P E Y
Chicken Gallus gallus
Frog Xenopus laevis NP_001088439 1243 140617 T461 R L V N W S C T L N S A I S D
Zebra Danio Brachydanio rerio XP_682807 1111 123867 M416 H P F C D R K M P V V F D D F
Tiger Blowfish Takifugu rubipres P49696 1217 138200 S429 R L V N W S C S L N S A I S D
Fruit Fly Dros. melanogaster NP_524838 1049 118236 D370 R R L P I V C D E F V D M A F
Honey Bee Apis mellifera XP_395202 1043 121057 I364 C D R K L P I I A D E F V E M
Nematode Worm Caenorhab. elegans Q9U1Q4 1050 118902 A371 E M E F G T G A V K I T P A H
Sea Urchin Strong. purpuratus XP_001200958 1119 126755 T429 Q S A V H P F T G R R V P V I
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana P93736 1108 125908 P415 C D G I L V D P N F G T G C V
Baker's Yeast Sacchar. cerevisiae P07806 1104 125751 K416 Q H P F L P R K I P I I T D K
Red Bread Mold Neurospora crassa P28350 1093 123334 N412 L L P I V T D N Y V D K E F G
Conservation
Percent
Protein Identity: 100 99.5 43.4 92.8 N.A. 93.4 93.4 N.A. 63 N.A. 65.3 45 63.8 50.9 49.1 44.9 44.4
Protein Similarity: 100 99.8 56 95.6 N.A. 96.4 96.3 N.A. 69.8 N.A. 78 58.8 76.8 63.1 63.4 59.5 59.6
P-Site Identity: 100 100 0 100 N.A. 100 100 N.A. 6.6 N.A. 100 0 93.3 13.3 0 0 6.6
P-Site Similarity: 100 100 33.3 100 N.A. 100 100 N.A. 6.6 N.A. 100 0 100 33.3 13.3 26.6 13.3
Percent
Protein Identity: N.A. N.A. N.A. 41.6 42.6 40.3
Protein Similarity: N.A. N.A. N.A. 58.3 60.1 56
P-Site Identity: N.A. N.A. N.A. 0 0 6.6
P-Site Similarity: N.A. N.A. N.A. 0 13.3 13.3
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 6 0 0 6 0 6 6 0 0 42 0 12 6 % A
% Cys: 12 0 0 6 0 0 48 0 0 0 0 0 0 6 0 % C
% Asp: 0 12 0 6 6 0 12 6 0 6 6 6 6 12 42 % D
% Glu: 6 0 6 0 0 6 0 0 6 0 6 0 6 12 0 % E
% Phe: 0 0 6 12 0 0 6 0 0 18 6 12 0 6 12 % F
% Gly: 0 0 6 0 6 0 6 0 12 0 6 6 6 6 6 % G
% His: 6 6 0 0 6 0 0 0 0 6 0 0 0 0 6 % H
% Ile: 0 6 0 12 6 0 6 6 6 0 12 6 42 0 6 % I
% Lys: 0 0 0 6 0 0 6 6 0 6 0 12 0 0 6 % K
% Leu: 12 48 6 0 18 0 0 0 42 0 0 0 0 0 0 % L
% Met: 0 6 0 0 0 0 0 6 0 0 0 0 6 0 6 % M
% Asn: 0 0 0 42 0 0 0 6 6 42 0 0 0 0 0 % N
% Pro: 0 6 18 6 0 18 0 6 12 6 0 0 18 0 0 % P
% Gln: 12 0 0 0 0 0 0 12 0 0 0 0 0 0 0 % Q
% Arg: 48 6 6 0 0 6 6 0 0 6 6 0 0 0 0 % R
% Ser: 0 6 0 0 0 42 6 6 0 0 42 0 0 42 0 % S
% Thr: 0 0 6 0 0 12 0 42 0 0 0 12 12 0 0 % T
% Val: 0 0 42 6 6 12 6 0 6 12 18 6 6 6 6 % V
% Trp: 6 0 0 6 48 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 6 0 0 6 0 0 0 6 0 0 0 0 0 6 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _