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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PON1 All Species: 25.45
Human Site: Y294 Identified Species: 80
UniProt: P27169 Number Species: 7
    Phosphosite Substitution
    Charge Score: 0.14
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P27169 NP_000437.3 355 39749 Y294 N G M K I F F Y D S E N P P A
Chimpanzee Pan troglodytes XP_519211 355 39709 Y294 N G M K I F F Y D S E N P P A
Rhesus Macaque Macaca mulatta XP_001095992 355 39781 Y294 N G M K V F F Y D S E N P P A
Dog Lupus familis XP_850219 355 40021 Y294 N G I R I F F Y D S E N P P A
Cat Felis silvestris
Mouse Mus musculus P52430 355 39547 Y294 N G M R I F F Y D A E N P P G
Rat Rattus norvegicus P55159 355 39478 Y294 N G M R I F F Y D S E N P P G
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus Q90952 354 39390 D293 N G M K L F Y D D P D N P P A
Frog Xenopus laevis NP_001084979 356 39849 Y294 N G W K L F S Y N S D D L P G
Zebra Danio Brachydanio rerio
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 98.8 95.7 87.6 N.A. 81.9 80 N.A. N.A. 67.6 58.1 N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: 100 100 99.1 94.3 N.A. 92.3 90.1 N.A. N.A. 80.8 75.2 N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: 100 100 93.3 86.6 N.A. 80 86.6 N.A. N.A. 66.6 46.6 N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: 100 100 100 100 N.A. 93.3 93.3 N.A. N.A. 86.6 73.3 N.A. N.A. N.A. N.A. N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 0 0 0 0 13 0 0 0 0 63 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 0 13 88 0 25 13 0 0 0 % D
% Glu: 0 0 0 0 0 0 0 0 0 0 75 0 0 0 0 % E
% Phe: 0 0 0 0 0 100 75 0 0 0 0 0 0 0 0 % F
% Gly: 0 100 0 0 0 0 0 0 0 0 0 0 0 0 38 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 13 0 63 0 0 0 0 0 0 0 0 0 0 % I
% Lys: 0 0 0 63 0 0 0 0 0 0 0 0 0 0 0 % K
% Leu: 0 0 0 0 25 0 0 0 0 0 0 0 13 0 0 % L
% Met: 0 0 75 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 100 0 0 0 0 0 0 0 13 0 0 88 0 0 0 % N
% Pro: 0 0 0 0 0 0 0 0 0 13 0 0 88 100 0 % P
% Gln: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Q
% Arg: 0 0 0 38 0 0 0 0 0 0 0 0 0 0 0 % R
% Ser: 0 0 0 0 0 0 13 0 0 75 0 0 0 0 0 % S
% Thr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % T
% Val: 0 0 0 0 13 0 0 0 0 0 0 0 0 0 0 % V
% Trp: 0 0 13 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 13 88 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _