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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: MARK3 All Species: 22.73
Human Site: S608 Identified Species: 45.45
UniProt: P27448 Number Species: 11
    Phosphosite Substitution
    Charge Score: -0.09
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P27448 NP_001122390.1 776 87005 S608 N G P P A S P S L S H E A T P
Chimpanzee Pan troglodytes XP_510184 737 82858 S569 N G P P A S P S L S H E A T P
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_868647 777 86967 S609 N G P P A S P S L S H E A T P
Cat Felis silvestris
Mouse Mus musculus Q03141 753 84371 S585 N G P P A S P S L S H E A T P
Rat Rattus norvegicus Q8VHF0 797 88733 P585 T F K A I T T P D Q R T P V A
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001508081 736 82480 S577 N G P P A S P S L S H E A T P
Chicken Gallus gallus Q9IA88 798 88848 R619 V C Q S S S S R A A R S A M S
Frog Xenopus laevis NP_001084256 725 81522 S581 N G P P A S P S L S H E A T P
Zebra Danio Brachydanio rerio Q6NSM8 1187 130949 L820 H R V L G K Q L S A D N A E T
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans Q9TW45 1192 126331 I1024 A N N A E A T I W S K L S K L
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q38997 535 61163 L393 A S P V S H R L P G L M E Y Q
Baker's Yeast Sacchar. cerevisiae P06782 633 72027 A489 M L A Q G S P A A S K I S P L
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 94.7 N.A. 96.4 N.A. 94 89.9 N.A. 90.5 31.4 85.6 26.5 N.A. N.A. N.A. 39.8 N.A.
Protein Similarity: 100 94.7 N.A. 97.4 N.A. 95 91.2 N.A. 92.9 50.7 89.5 42.6 N.A. N.A. N.A. 51 N.A.
P-Site Identity: 100 100 N.A. 100 N.A. 100 0 N.A. 100 13.3 100 6.6 N.A. N.A. N.A. 6.6 N.A.
P-Site Similarity: 100 100 N.A. 100 N.A. 100 6.6 N.A. 100 26.6 100 20 N.A. N.A. N.A. 20 N.A.
Percent
Protein Identity: N.A. N.A. N.A. 27 27.3 N.A.
Protein Similarity: N.A. N.A. N.A. 44 45.8 N.A.
P-Site Identity: N.A. N.A. N.A. 6.6 20 N.A.
P-Site Similarity: N.A. N.A. N.A. 13.3 33.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 17 0 9 17 50 9 0 9 17 17 0 0 67 0 9 % A
% Cys: 0 9 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 0 0 9 0 9 0 0 0 0 % D
% Glu: 0 0 0 0 9 0 0 0 0 0 0 50 9 9 0 % E
% Phe: 0 9 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 50 0 0 17 0 0 0 0 9 0 0 0 0 0 % G
% His: 9 0 0 0 0 9 0 0 0 0 50 0 0 0 0 % H
% Ile: 0 0 0 0 9 0 0 9 0 0 0 9 0 0 0 % I
% Lys: 0 0 9 0 0 9 0 0 0 0 17 0 0 9 0 % K
% Leu: 0 9 0 9 0 0 0 17 50 0 9 9 0 0 17 % L
% Met: 9 0 0 0 0 0 0 0 0 0 0 9 0 9 0 % M
% Asn: 50 9 9 0 0 0 0 0 0 0 0 9 0 0 0 % N
% Pro: 0 0 59 50 0 0 59 9 9 0 0 0 9 9 50 % P
% Gln: 0 0 9 9 0 0 9 0 0 9 0 0 0 0 9 % Q
% Arg: 0 9 0 0 0 0 9 9 0 0 17 0 0 0 0 % R
% Ser: 0 9 0 9 17 67 9 50 9 67 0 9 17 0 9 % S
% Thr: 9 0 0 0 0 9 17 0 0 0 0 9 0 50 9 % T
% Val: 9 0 9 9 0 0 0 0 0 0 0 0 0 9 0 % V
% Trp: 0 0 0 0 0 0 0 0 9 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 9 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _