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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: ATP6V0C All Species: 8.48
Human Site: S12 Identified Species: 11.67
UniProt: P27449 Number Species: 16
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P27449 NP_001685.1 155 15736 S12 K S G P E Y A S F F A V M G A
Chimpanzee Pan troglodytes XP_510748 156 15775 F13 S G P E Y A S F F A V M G A S
Rhesus Macaque Macaca mulatta XP_001085529 417 43146 A274 H L G V L A P A G L R T A V G
Dog Lupus familis XP_537002 155 15683 S12 K N G P E Y A S F F A V M G A
Cat Felis silvestris
Mouse Mus musculus Q91V37 205 21588 F47 F L T E T S P F M W S N L G I
Rat Rattus norvegicus P63081 155 15789 S12 K N N P E Y S S F F G V M G A
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus XP_001232268 133 13418
Frog Xenopus laevis NP_001082675 156 15788 A13 A S A P E Y S A F F A V M G A
Zebra Danio Brachydanio rerio NP_991117 153 15480 V14 E Y S P F F A V M G A S A A M
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P23380 159 16249 P14 S D N P I Y G P F F G V M G A
Honey Bee Apis mellifera NP_001011570 156 15953 F13 H P I Y A P F F G V M G A A S
Nematode Worm Caenorhab. elegans P34546 161 16391 P15 A E R A A Y A P F F G Y M G A
Sea Urchin Strong. purpuratus XP_797801 155 15612 G12 P A Y T P F F G V M G A T S A
Poplar Tree Populus trichocarpa
Maize Zea mays Q41773 109 11025
Rice Oryza sativa
Thale Cress Arabidopsis thaliana P59228 165 16624 P12 F S G D E T A P F F G F L G A
Baker's Yeast Sacchar. cerevisiae P25515 160 16332 A14 V Y A P F F G A I G C A S A I
Red Bread Mold Neurospora crassa P31413 161 16311 M15 Y A P F F G A M G C T A A I V
Conservation
Percent
Protein Identity: 100 98 35.2 96.7 N.A. 26.8 90.9 N.A. N.A. 81.2 92.3 92.2 N.A. 80.5 80.7 66.4 82.5
Protein Similarity: 100 98.7 36.4 98.7 N.A. 43.9 96.1 N.A. N.A. 83.8 95.5 94.8 N.A. 86.7 87.8 75.1 90.9
P-Site Identity: 100 6.6 6.6 93.3 N.A. 6.6 73.3 N.A. N.A. 0 73.3 20 N.A. 53.3 0 46.6 6.6
P-Site Similarity: 100 26.6 13.3 100 N.A. 26.6 86.6 N.A. N.A. 0 86.6 33.3 N.A. 53.3 6.6 46.6 20
Percent
Protein Identity: N.A. 43.2 N.A. 60 68.7 70.1
Protein Similarity: N.A. 50.9 N.A. 76.3 82.5 84.4
P-Site Identity: N.A. 0 N.A. 53.3 6.6 6.6
P-Site Similarity: N.A. 0 N.A. 60 20 13.3
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 12 12 12 6 12 12 36 18 0 6 24 18 24 24 48 % A
% Cys: 0 0 0 0 0 0 0 0 0 6 6 0 0 0 0 % C
% Asp: 0 6 0 6 0 0 0 0 0 0 0 0 0 0 0 % D
% Glu: 6 6 0 12 30 0 0 0 0 0 0 0 0 0 0 % E
% Phe: 12 0 0 6 18 18 12 18 48 42 0 6 0 0 0 % F
% Gly: 0 6 24 0 0 6 12 6 18 12 30 6 6 48 6 % G
% His: 12 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 6 0 6 0 0 0 6 0 0 0 0 6 12 % I
% Lys: 18 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % K
% Leu: 0 12 0 0 6 0 0 0 0 6 0 0 12 0 0 % L
% Met: 0 0 0 0 0 0 0 6 12 6 6 6 36 0 6 % M
% Asn: 0 12 12 0 0 0 0 0 0 0 0 6 0 0 0 % N
% Pro: 6 6 12 42 6 6 12 18 0 0 0 0 0 0 0 % P
% Gln: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Q
% Arg: 0 0 6 0 0 0 0 0 0 0 6 0 0 0 0 % R
% Ser: 12 18 6 0 0 6 18 18 0 0 6 6 6 6 12 % S
% Thr: 0 0 6 6 6 6 0 0 0 0 6 6 6 0 0 % T
% Val: 6 0 0 6 0 0 0 6 6 6 6 30 0 6 6 % V
% Trp: 0 0 0 0 0 0 0 0 0 6 0 0 0 0 0 % W
% Tyr: 6 12 6 6 6 36 0 0 0 0 0 6 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _