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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: ATP6V0C All Species: 7.84
Human Site: S6 Identified Species: 10.78
UniProt: P27449 Number Species: 16
    Phosphosite Substitution
    Charge Score: 0.13
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P27449 NP_001685.1 155 15736 S6 _ _ M S E S K S G P E Y A S F
Chimpanzee Pan troglodytes XP_510748 156 15775 G7 _ M S E S K S G P E Y A S F F
Rhesus Macaque Macaca mulatta XP_001085529 417 43146 L268 A A V P K L H L G V L A P A G
Dog Lupus familis XP_537002 155 15683 N6 _ _ M S E A K N G P E Y A S F
Cat Felis silvestris
Mouse Mus musculus Q91V37 205 21588 L41 R F D V A W F L T E T S P F M
Rat Rattus norvegicus P63081 155 15789 N6 _ _ M A D I K N N P E Y S S F
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus XP_001232268 133 13418
Frog Xenopus laevis NP_001082675 156 15788 S7 _ M S V E T A S A P E Y S A F
Zebra Danio Brachydanio rerio NP_991117 153 15480 Y8 M S S G S P E Y S P F F A V M
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P23380 159 16249 D8 M S S E V S S D N P I Y G P F
Honey Bee Apis mellifera NP_001011570 156 15953 P7 _ M S D E D H P I Y A P F F G
Nematode Worm Caenorhab. elegans P34546 161 16391 E9 S Y D L E T A E R A A Y A P F
Sea Urchin Strong. purpuratus XP_797801 155 15612 A6 _ _ M A E N P A Y T P F F G V
Poplar Tree Populus trichocarpa
Maize Zea mays Q41773 109 11025
Rice Oryza sativa
Thale Cress Arabidopsis thaliana P59228 165 16624 S6 _ _ M A S T F S G D E T A P F
Baker's Yeast Sacchar. cerevisiae P25515 160 16332 Y8 M T E L C P V Y A P F F G A I
Red Bread Mold Neurospora crassa P31413 161 16311 A9 S D L C P V Y A P F F G A M G
Conservation
Percent
Protein Identity: 100 98 35.2 96.7 N.A. 26.8 90.9 N.A. N.A. 81.2 92.3 92.2 N.A. 80.5 80.7 66.4 82.5
Protein Similarity: 100 98.7 36.4 98.7 N.A. 43.9 96.1 N.A. N.A. 83.8 95.5 94.8 N.A. 86.7 87.8 75.1 90.9
P-Site Identity: 100 7.1 6.6 84.6 N.A. 0 53.8 N.A. N.A. 0 42.8 13.3 N.A. 26.6 7.1 26.6 15.3
P-Site Similarity: 100 14.2 26.6 100 N.A. 0 84.6 N.A. N.A. 0 64.2 26.6 N.A. 26.6 7.1 40 46.1
Percent
Protein Identity: N.A. 43.2 N.A. 60 68.7 70.1
Protein Similarity: N.A. 50.9 N.A. 76.3 82.5 84.4
P-Site Identity: N.A. 0 N.A. 46.1 6.6 6.6
P-Site Similarity: N.A. 0 N.A. 61.5 20 20
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 6 6 0 18 6 6 12 12 12 6 12 12 36 18 0 % A
% Cys: 0 0 0 6 6 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 6 12 6 6 6 0 6 0 6 0 0 0 0 0 % D
% Glu: 0 0 6 12 36 0 6 6 0 12 30 0 0 0 0 % E
% Phe: 0 6 0 0 0 0 12 0 0 6 18 18 12 18 48 % F
% Gly: 0 0 0 6 0 0 0 6 24 0 0 6 12 6 18 % G
% His: 0 0 0 0 0 0 12 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 6 0 0 6 0 6 0 0 0 6 % I
% Lys: 0 0 0 0 6 6 18 0 0 0 0 0 0 0 0 % K
% Leu: 0 0 6 12 0 6 0 12 0 0 6 0 0 0 0 % L
% Met: 18 18 30 0 0 0 0 0 0 0 0 0 0 6 12 % M
% Asn: 0 0 0 0 0 6 0 12 12 0 0 0 0 0 0 % N
% Pro: 0 0 0 6 6 12 6 6 12 42 6 6 12 18 0 % P
% Gln: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Q
% Arg: 6 0 0 0 0 0 0 0 6 0 0 0 0 0 0 % R
% Ser: 12 12 30 12 18 12 12 18 6 0 0 6 18 18 0 % S
% Thr: 0 6 0 0 0 18 0 0 6 6 6 6 0 0 0 % T
% Val: 0 0 6 12 6 6 6 0 0 6 0 0 0 6 6 % V
% Trp: 0 0 0 0 0 6 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 6 0 0 0 0 6 12 6 6 6 36 0 0 0 % Y
% Spaces: 48 30 0 0 0 0 0 0 0 0 0 0 0 0 0 % _