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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
DPP4
All Species:
6.06
Human Site:
Y386
Identified Species:
12.12
UniProt:
P27487
Number Species:
11
Phosphosite Substitution
Charge Score:
-0.09
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P27487
NP_001926.2
766
88279
Y386
E
G
Y
R
H
I
C
Y
F
Q
I
D
K
K
D
Chimpanzee
Pan troglodytes
Q5IS50
803
91393
S406
Y
H
I
T
M
S
L
S
Q
P
N
S
S
N
D
Rhesus Macaque
Macaca mulatta
NP_001034279
766
87851
Y386
E
G
Y
R
H
I
C
Y
F
Q
I
N
K
K
N
Dog
Lupus familis
XP_535933
755
86978
Q377
Y
K
H
I
C
Q
F
Q
I
D
K
Q
D
C
T
Cat
Felis silvestris
Mouse
Mus musculus
P28843
760
87418
P382
Y
K
H
I
C
H
F
P
K
D
K
K
D
C
T
Rat
Rattus norvegicus
P14740
767
88070
K387
K
H
I
C
Q
F
Q
K
D
R
K
P
E
Q
V
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001512879
748
86136
Y370
Y
K
H
I
H
R
F
Y
V
N
N
Q
S
P
E
Chicken
Gallus gallus
NP_001026426
759
86325
I381
G
Y
K
H
I
H
Y
I
N
G
T
E
A
P
V
Frog
Xenopus laevis
NP_001081519
748
85569
H370
K
E
G
Y
K
H
I
H
L
F
E
G
S
K
D
Zebra Danio
Brachydanio rerio
NP_001154809
742
84650
F364
I
L
S
N
D
E
R
F
K
H
L
A
Y
F
I
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q18253
829
94369
H438
D
D
G
N
I
Y
N
H
V
A
H
V
E
L
D
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P18962
818
93386
V435
L
T
E
G
K
W
E
V
V
N
G
P
L
A
F
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
33.1
97.6
84.9
N.A.
84.4
84.8
N.A.
69.4
64.3
58.6
55.7
N.A.
N.A.
N.A.
27.8
N.A.
Protein Similarity:
100
54.1
98.3
90.9
N.A.
92.3
92
N.A.
81.7
76.7
74
71.9
N.A.
N.A.
N.A.
46.6
N.A.
P-Site Identity:
100
6.6
86.6
0
N.A.
0
0
N.A.
13.3
0
13.3
0
N.A.
N.A.
N.A.
6.6
N.A.
P-Site Similarity:
100
6.6
100
6.6
N.A.
6.6
26.6
N.A.
26.6
6.6
26.6
13.3
N.A.
N.A.
N.A.
26.6
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
31.6
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
48.6
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
0
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
0
0
9
0
9
9
9
0
% A
% Cys:
0
0
0
9
17
0
17
0
0
0
0
0
0
17
0
% C
% Asp:
9
9
0
0
9
0
0
0
9
17
0
9
17
0
34
% D
% Glu:
17
9
9
0
0
9
9
0
0
0
9
9
17
0
9
% E
% Phe:
0
0
0
0
0
9
25
9
17
9
0
0
0
9
9
% F
% Gly:
9
17
17
9
0
0
0
0
0
9
9
9
0
0
0
% G
% His:
0
17
25
9
25
25
0
17
0
9
9
0
0
0
0
% H
% Ile:
9
0
17
25
17
17
9
9
9
0
17
0
0
0
9
% I
% Lys:
17
25
9
0
17
0
0
9
17
0
25
9
17
25
0
% K
% Leu:
9
9
0
0
0
0
9
0
9
0
9
0
9
9
0
% L
% Met:
0
0
0
0
9
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
17
0
0
9
0
9
17
17
9
0
9
9
% N
% Pro:
0
0
0
0
0
0
0
9
0
9
0
17
0
17
0
% P
% Gln:
0
0
0
0
9
9
9
9
9
17
0
17
0
9
0
% Q
% Arg:
0
0
0
17
0
9
9
0
0
9
0
0
0
0
0
% R
% Ser:
0
0
9
0
0
9
0
9
0
0
0
9
25
0
0
% S
% Thr:
0
9
0
9
0
0
0
0
0
0
9
0
0
0
17
% T
% Val:
0
0
0
0
0
0
0
9
25
0
0
9
0
0
17
% V
% Trp:
0
0
0
0
0
9
0
0
0
0
0
0
0
0
0
% W
% Tyr:
34
9
17
9
0
9
9
25
0
0
0
0
9
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _