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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: LASS1 All Species: 7.88
Human Site: S18 Identified Species: 12.38
UniProt: P27544 Number Species: 14
    Phosphosite Substitution
    Charge Score: -0.14
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P27544 NP_067090.1 350 39536 S18 T G P E P M P S Y A Q L V Q R
Chimpanzee Pan troglodytes XP_524160 413 46292 R68 T G P E P M P R Y A Q L V Q R
Rhesus Macaque Macaca mulatta XP_001115596 252 29440
Dog Lupus familis XP_852219 170 19061
Cat Felis silvestris
Mouse Mus musculus P27545 350 40082 S18 E A P E P M P S Y A Q M L Q R
Rat Rattus norvegicus NP_001037695 350 39960 S18 E A P E P M P S Y A E M L Q R
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001509533 301 35212
Chicken Gallus gallus XP_418236 354 41217 R16 G Y G Q L L R R G Y G S L A A
Frog Xenopus laevis
Zebra Danio Brachydanio rerio XP_696339 371 43596 G22 M E M E M T P G Y M E L T S R
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans NP_493403 360 42724 L24 S T A N P I V L A G L V F E S
Sea Urchin Strong. purpuratus XP_796958 456 53475 F18 S P N Y F R L F R M V L E E L
Poplar Tree Populus trichocarpa XP_002311424 308 36356 W12 E Y V K S I E W E H E S Y P G
Maize Zea mays NP_001149162 313 36527 V16 L G S S S A P V D W E A E A Y
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9LDF2 310 36479 Q14 V K S I D W E Q E S F P T Y Q
Baker's Yeast Sacchar. cerevisiae P28496 418 48974 N63 R L S E A T K N D S D L V K K
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 80.8 70.8 35.4 N.A. 80.8 80.5 N.A. 64 70.9 N.A. 52.5 N.A. N.A. N.A. 32.2 30.2
Protein Similarity: 100 82.5 70.8 40.5 N.A. 87.4 88 N.A. 71.7 79.6 N.A. 68.1 N.A. N.A. N.A. 48.3 45.3
P-Site Identity: 100 93.3 0 0 N.A. 73.3 66.6 N.A. 0 0 N.A. 33.3 N.A. N.A. N.A. 6.6 6.6
P-Site Similarity: 100 93.3 0 0 N.A. 86.6 86.6 N.A. 0 20 N.A. 40 N.A. N.A. N.A. 33.3 20
Percent
Protein Identity: 24.5 27.1 N.A. 22.8 20.3 N.A.
Protein Similarity: 40.8 41.4 N.A. 40 33.4 N.A.
P-Site Identity: 0 13.3 N.A. 0 20 N.A.
P-Site Similarity: 20 20 N.A. 13.3 46.6 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 14 7 0 7 7 0 0 7 27 0 7 0 14 7 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 7 0 0 0 14 0 7 0 0 0 0 % D
% Glu: 20 7 0 40 0 0 14 0 14 0 27 0 14 14 0 % E
% Phe: 0 0 0 0 7 0 0 7 0 0 7 0 7 0 0 % F
% Gly: 7 20 7 0 0 0 0 7 7 7 7 0 0 0 7 % G
% His: 0 0 0 0 0 0 0 0 0 7 0 0 0 0 0 % H
% Ile: 0 0 0 7 0 14 0 0 0 0 0 0 0 0 0 % I
% Lys: 0 7 0 7 0 0 7 0 0 0 0 0 0 7 7 % K
% Leu: 7 7 0 0 7 7 7 7 0 0 7 34 20 0 7 % L
% Met: 7 0 7 0 7 27 0 0 0 14 0 14 0 0 0 % M
% Asn: 0 0 7 7 0 0 0 7 0 0 0 0 0 0 0 % N
% Pro: 0 7 27 0 34 0 40 0 0 0 0 7 0 7 0 % P
% Gln: 0 0 0 7 0 0 0 7 0 0 20 0 0 27 7 % Q
% Arg: 7 0 0 0 0 7 7 14 7 0 0 0 0 0 34 % R
% Ser: 14 0 20 7 14 0 0 20 0 14 0 14 0 7 7 % S
% Thr: 14 7 0 0 0 14 0 0 0 0 0 0 14 0 0 % T
% Val: 7 0 7 0 0 0 7 7 0 0 7 7 20 0 0 % V
% Trp: 0 0 0 0 0 7 0 7 0 7 0 0 0 0 0 % W
% Tyr: 0 14 0 7 0 0 0 0 34 7 0 0 7 7 7 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _