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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: LASS1 All Species: 8.79
Human Site: S334 Identified Species: 13.81
UniProt: P27544 Number Species: 14
    Phosphosite Substitution
    Charge Score: 0.14
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P27544 NP_067090.1 350 39536 S334 E A Q S L K P S K A E K P L R
Chimpanzee Pan troglodytes XP_524160 413 46292 S384 E A Q S L K P S K A E E A V A
Rhesus Macaque Macaca mulatta XP_001115596 252 29440 G245 A E K P L R N G L V K D K R F
Dog Lupus familis XP_852219 170 19061 C163 A L A A D L G C L S F S V S W
Cat Felis silvestris
Mouse Mus musculus P27545 350 40082 C334 E A Q T A K P C K A E K P L R
Rat Rattus norvegicus NP_001037695 350 39960 C334 E A Q T A K P C R A E K P L R
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001509533 301 35212 S294 L S L R K E G S L K T W K E E
Chicken Gallus gallus XP_418236 354 41217 A325 D S K K T T A A K K K E S G L
Frog Xenopus laevis
Zebra Danio Brachydanio rerio XP_696339 371 43596 S338 D L K E R K D S S D E A S T E
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans NP_493403 360 42724 Q342 T A V S G L N Q Q K L D E L A
Sea Urchin Strong. purpuratus XP_796958 456 53475 N413 E H I D A D G N V K E E K E K
Poplar Tree Populus trichocarpa XP_002311424 308 36356 E301 D D V R S D S E G E D E H E D
Maize Zea mays NP_001149162 313 36527 S305 G D D V R S D S E G E E E H E
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9LDF2 310 36479 E303 E D V R S D S E S D D E H E D
Baker's Yeast Sacchar. cerevisiae P28496 418 48974 T407 E S D E S S T T P T D S T P T
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 80.8 70.8 35.4 N.A. 80.8 80.5 N.A. 64 70.9 N.A. 52.5 N.A. N.A. N.A. 32.2 30.2
Protein Similarity: 100 82.5 70.8 40.5 N.A. 87.4 88 N.A. 71.7 79.6 N.A. 68.1 N.A. N.A. N.A. 48.3 45.3
P-Site Identity: 100 73.3 6.6 0 N.A. 80 73.3 N.A. 6.6 6.6 N.A. 20 N.A. N.A. N.A. 20 13.3
P-Site Similarity: 100 86.6 26.6 13.3 N.A. 86.6 86.6 N.A. 20 46.6 N.A. 33.3 N.A. N.A. N.A. 26.6 33.3
Percent
Protein Identity: 24.5 27.1 N.A. 22.8 20.3 N.A.
Protein Similarity: 40.8 41.4 N.A. 40 33.4 N.A.
P-Site Identity: 0 13.3 N.A. 6.6 6.6 N.A.
P-Site Similarity: 20 26.6 N.A. 20 26.6 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 14 34 7 7 20 0 7 7 0 27 0 7 7 0 14 % A
% Cys: 0 0 0 0 0 0 0 20 0 0 0 0 0 0 0 % C
% Asp: 20 20 14 7 7 20 14 0 0 14 20 14 0 0 14 % D
% Glu: 47 7 0 14 0 7 0 14 7 7 47 40 14 27 20 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 7 0 0 0 7 % F
% Gly: 7 0 0 0 7 0 20 7 7 7 0 0 0 7 0 % G
% His: 0 7 0 0 0 0 0 0 0 0 0 0 14 7 0 % H
% Ile: 0 0 7 0 0 0 0 0 0 0 0 0 0 0 0 % I
% Lys: 0 0 20 7 7 34 0 0 27 27 14 20 20 0 7 % K
% Leu: 7 14 7 0 20 14 0 0 20 0 7 0 0 27 7 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 14 7 0 0 0 0 0 0 0 % N
% Pro: 0 0 0 7 0 0 27 0 7 0 0 0 20 7 0 % P
% Gln: 0 0 27 0 0 0 0 7 7 0 0 0 0 0 0 % Q
% Arg: 0 0 0 20 14 7 0 0 7 0 0 0 0 7 20 % R
% Ser: 0 20 0 20 20 14 14 34 14 7 0 14 14 7 0 % S
% Thr: 7 0 0 14 7 7 7 7 0 7 7 0 7 7 7 % T
% Val: 0 0 20 7 0 0 0 0 7 7 0 0 7 7 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 7 0 0 7 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _