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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: LASS1 All Species: 9.09
Human Site: T139 Identified Species: 14.29
UniProt: P27544 Number Species: 14
    Phosphosite Substitution
    Charge Score: -0.36
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P27544 NP_067090.1 350 39536 T139 P S V F Y D W T P G M A V P R
Chimpanzee Pan troglodytes XP_524160 413 46292 T189 P S V F Y D W T P G M A V P R
Rhesus Macaque Macaca mulatta XP_001115596 252 29440 I50 G M A V P R D I A A A Y L L Q
Dog Lupus familis XP_852219 170 19061
Cat Felis silvestris
Mouse Mus musculus P27545 350 40082 R139 P S V F Y D W R S G M A V P W
Rat Rattus norvegicus NP_001037695 350 39960 R139 P S V F Y G W R S G M A V P W
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001509533 301 35212 V99 D W K T G M A V P R D I A V A
Chicken Gallus gallus XP_418236 354 41217 K130 P S V F Y D W K K G M D V P T
Frog Xenopus laevis
Zebra Danio Brachydanio rerio XP_696339 371 43596 K143 P S V F Y D W K S G M S V P T
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans NP_493403 360 42724 G147 M W I E W E S G G R P K M H W
Sea Urchin Strong. purpuratus XP_796958 456 53475 S131 P K S F I G W S A D M E I P W
Poplar Tree Populus trichocarpa XP_002311424 308 36356 K106 E P W L V N T K Y F W V G P G
Maize Zea mays NP_001149162 313 36527 T110 N E P W F K N T R Y F W I G P
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9LDF2 310 36479 T108 N E P W F S N T L Y F W I G P
Baker's Yeast Sacchar. cerevisiae P28496 418 48974 P212 K A M Y R T Y P D F T N P F L
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 80.8 70.8 35.4 N.A. 80.8 80.5 N.A. 64 70.9 N.A. 52.5 N.A. N.A. N.A. 32.2 30.2
Protein Similarity: 100 82.5 70.8 40.5 N.A. 87.4 88 N.A. 71.7 79.6 N.A. 68.1 N.A. N.A. N.A. 48.3 45.3
P-Site Identity: 100 100 0 0 N.A. 80 73.3 N.A. 6.6 73.3 N.A. 73.3 N.A. N.A. N.A. 0 33.3
P-Site Similarity: 100 100 13.3 0 N.A. 80 73.3 N.A. 6.6 73.3 N.A. 80 N.A. N.A. N.A. 26.6 46.6
Percent
Protein Identity: 24.5 27.1 N.A. 22.8 20.3 N.A.
Protein Similarity: 40.8 41.4 N.A. 40 33.4 N.A.
P-Site Identity: 6.6 6.6 N.A. 6.6 0 N.A.
P-Site Similarity: 13.3 26.6 N.A. 26.6 26.6 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 7 7 0 0 0 7 0 14 7 7 27 7 0 7 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 7 0 0 0 0 34 7 0 7 7 7 7 0 0 0 % D
% Glu: 7 14 0 7 0 7 0 0 0 0 0 7 0 0 0 % E
% Phe: 0 0 0 47 14 0 0 0 0 14 14 0 0 7 0 % F
% Gly: 7 0 0 0 7 14 0 7 7 40 0 0 7 14 7 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 7 0 % H
% Ile: 0 0 7 0 7 0 0 7 0 0 0 7 20 0 0 % I
% Lys: 7 7 7 0 0 7 0 20 7 0 0 7 0 0 0 % K
% Leu: 0 0 0 7 0 0 0 0 7 0 0 0 7 7 7 % L
% Met: 7 7 7 0 0 7 0 0 0 0 47 0 7 0 0 % M
% Asn: 14 0 0 0 0 7 14 0 0 0 0 7 0 0 0 % N
% Pro: 47 7 14 0 7 0 0 7 20 0 7 0 7 54 14 % P
% Gln: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 7 % Q
% Arg: 0 0 0 0 7 7 0 14 7 14 0 0 0 0 14 % R
% Ser: 0 40 7 0 0 7 7 7 20 0 0 7 0 0 0 % S
% Thr: 0 0 0 7 0 7 7 27 0 0 7 0 0 0 14 % T
% Val: 0 0 40 7 7 0 0 7 0 0 0 7 40 7 0 % V
% Trp: 0 14 7 14 7 0 47 0 0 0 7 14 0 0 27 % W
% Tyr: 0 0 0 7 40 0 7 0 7 14 0 7 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _