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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: APEX1 All Species: 39.39
Human Site: Y128 Identified Species: 78.79
UniProt: P27695 Number Species: 11
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P27695 NP_001632.2 318 35555 Y128 A P S D K E G Y S G V G L L S
Chimpanzee Pan troglodytes NP_001074954 318 35550 Y128 A P S D K E G Y S G V G L L S
Rhesus Macaque Macaca mulatta XP_001089542 318 35613 Y128 A P S D K E G Y S G V G L L S
Dog Lupus familis
Cat Felis silvestris
Mouse Mus musculus P28352 317 35472 Y127 A P S D K E G Y S G V G L L S
Rat Rattus norvegicus P43138 317 35520 Y127 A P S D K E G Y S G V G L L S
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001516262 324 36013 Y134 A P A D K E G Y S G V G L L S
Chicken Gallus gallus
Frog Xenopus laevis NP_001085229 316 35897 Y127 C P D E K E G Y S G V A M L C
Zebra Danio Brachydanio rerio NP_998586 310 34876 Y121 G S E D K E G Y S G V A M L C
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P27864 679 74616 Y490 W L C M P G G Y A G V A I Y S
Honey Bee Apis mellifera XP_623551 336 38693 Y147 L E S K K S G Y C G V A L F T
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_789515 302 34300 Y112 N A A E K K G Y S G V A L F S
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana P45951 536 60242 Y346 C S V S K L G Y S G T A I I S
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.6 98.1 N.A. N.A. 94.3 93.4 N.A. 78 N.A. 66.6 66.3 N.A. 28.5 47.3 N.A. 51.5
Protein Similarity: 100 100 98.7 N.A. N.A. 96.8 96.5 N.A. 87.3 N.A. 77.9 78.3 N.A. 35.9 63.3 N.A. 68.5
P-Site Identity: 100 100 100 N.A. N.A. 100 100 N.A. 93.3 N.A. 60 60 N.A. 33.3 46.6 N.A. 53.3
P-Site Similarity: 100 100 100 N.A. N.A. 100 100 N.A. 100 N.A. 73.3 66.6 N.A. 46.6 53.3 N.A. 73.3
Percent
Protein Identity: N.A. N.A. N.A. 30.2 N.A. N.A.
Protein Similarity: N.A. N.A. N.A. 38.6 N.A. N.A.
P-Site Identity: N.A. N.A. N.A. 40 N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. 53.3 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 50 9 17 0 0 0 0 0 9 0 0 50 0 0 0 % A
% Cys: 17 0 9 0 0 0 0 0 9 0 0 0 0 0 17 % C
% Asp: 0 0 9 59 0 0 0 0 0 0 0 0 0 0 0 % D
% Glu: 0 9 9 17 0 67 0 0 0 0 0 0 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 17 0 % F
% Gly: 9 0 0 0 0 9 100 0 0 100 0 50 0 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 0 0 0 0 0 0 0 17 9 0 % I
% Lys: 0 0 0 9 92 9 0 0 0 0 0 0 0 0 0 % K
% Leu: 9 9 0 0 0 9 0 0 0 0 0 0 67 67 0 % L
% Met: 0 0 0 9 0 0 0 0 0 0 0 0 17 0 0 % M
% Asn: 9 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % N
% Pro: 0 59 0 0 9 0 0 0 0 0 0 0 0 0 0 % P
% Gln: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Q
% Arg: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % R
% Ser: 0 17 50 9 0 9 0 0 84 0 0 0 0 0 75 % S
% Thr: 0 0 0 0 0 0 0 0 0 0 9 0 0 0 9 % T
% Val: 0 0 9 0 0 0 0 0 0 0 92 0 0 0 0 % V
% Trp: 9 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 100 0 0 0 0 0 9 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _