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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
APEX1
All Species:
37.27
Human Site:
Y257
Identified Species:
74.55
UniProt:
P27695
Number Species:
11
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P27695
NP_001632.2
318
35555
Y257
A
D
S
F
R
H
L
Y
P
N
T
P
Y
A
Y
Chimpanzee
Pan troglodytes
NP_001074954
318
35550
Y257
A
D
S
F
R
H
L
Y
P
N
T
P
Y
A
Y
Rhesus Macaque
Macaca mulatta
XP_001089542
318
35613
Y257
A
D
S
F
R
H
L
Y
P
N
T
P
Y
A
Y
Dog
Lupus familis
Cat
Felis silvestris
Mouse
Mus musculus
P28352
317
35472
Y256
A
D
S
F
R
H
L
Y
P
N
T
A
Y
A
Y
Rat
Rattus norvegicus
P43138
317
35520
Y256
A
D
S
F
R
H
L
Y
P
N
T
A
Y
A
Y
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001516262
324
36013
Y263
A
D
S
F
R
H
L
Y
P
A
A
A
Y
A
Y
Chicken
Gallus gallus
Frog
Xenopus laevis
NP_001085229
316
35897
Y255
L
D
S
F
R
E
L
Y
P
D
K
P
S
A
Y
Zebra Danio
Brachydanio rerio
NP_998586
310
34876
Y249
T
D
S
F
R
E
L
Y
P
D
Q
A
Y
A
Y
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P27864
679
74616
Y618
V
D
T
F
R
H
L
Y
P
D
R
K
G
A
Y
Honey Bee
Apis mellifera
XP_623551
336
38693
Y275
V
D
T
F
R
A
L
Y
P
D
K
T
D
A
Y
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_789515
302
34300
Y241
V
D
S
F
R
H
L
Y
P
E
E
A
D
A
Y
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P45951
536
60242
Q475
F
V
D
T
F
R
K
Q
H
P
G
V
V
G
Y
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.6
98.1
N.A.
N.A.
94.3
93.4
N.A.
78
N.A.
66.6
66.3
N.A.
28.5
47.3
N.A.
51.5
Protein Similarity:
100
100
98.7
N.A.
N.A.
96.8
96.5
N.A.
87.3
N.A.
77.9
78.3
N.A.
35.9
63.3
N.A.
68.5
P-Site Identity:
100
100
100
N.A.
N.A.
93.3
93.3
N.A.
80
N.A.
66.6
66.6
N.A.
60
53.3
N.A.
66.6
P-Site Similarity:
100
100
100
N.A.
N.A.
93.3
93.3
N.A.
80
N.A.
73.3
73.3
N.A.
73.3
66.6
N.A.
66.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
30.2
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
38.6
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
6.6
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
6.6
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
50
0
0
0
0
9
0
0
0
9
9
42
0
92
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
92
9
0
0
0
0
0
0
34
0
0
17
0
0
% D
% Glu:
0
0
0
0
0
17
0
0
0
9
9
0
0
0
0
% E
% Phe:
9
0
0
92
9
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
9
0
9
9
0
% G
% His:
0
0
0
0
0
67
0
0
9
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
0
0
0
0
0
9
0
0
0
17
9
0
0
0
% K
% Leu:
9
0
0
0
0
0
92
0
0
0
0
0
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
42
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
92
9
0
34
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
9
0
0
9
0
0
0
0
% Q
% Arg:
0
0
0
0
92
9
0
0
0
0
9
0
0
0
0
% R
% Ser:
0
0
75
0
0
0
0
0
0
0
0
0
9
0
0
% S
% Thr:
9
0
17
9
0
0
0
0
0
0
42
9
0
0
0
% T
% Val:
25
9
0
0
0
0
0
0
0
0
0
9
9
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
92
0
0
0
0
59
0
100
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _