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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: CAD All Species: 25.45
Human Site: S1014 Identified Species: 62.22
UniProt: P27708 Number Species: 9
    Phosphosite Substitution
    Charge Score: -0.22
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P27708 NP_004332.2 2225 242984 S1014 N P E G V I L S M G G Q L P N
Chimpanzee Pan troglodytes XP_001155357 2225 242993 S1014 N P E G V I L S M G G Q L P N
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_540124 2288 250188 S1060 N P E G V I L S M G G Q L P N
Cat Felis silvestris
Mouse Mus musculus Q8C196 1500 164599 R419 K P A L V A S R V E V S K V L
Rat Rattus norvegicus P07756 1500 164561 R419 K P A L V A S R V E V S K V L
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus
Frog Xenopus laevis
Zebra Danio Brachydanio rerio NP_001009884 2230 247184 S1019 N P E G V I L S M G G Q L P N
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P05990 2224 246654 S1028 N S E G I I L S M G G Q L P N
Honey Bee Apis mellifera XP_393888 2241 249499 S1028 F P E G I I L S M G G Q L P N
Nematode Worm Caenorhab. elegans NP_495838 2198 242563 A1016 K P K G V I L A F G G Q A P N
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P07259 2214 245107 S1061 N S S G V V V S M G G Q T S N
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.9 N.A. 94.8 N.A. 36.2 36.3 N.A. N.A. N.A. N.A. 76.8 N.A. 64.5 63.6 57.8 N.A.
Protein Similarity: 100 100 N.A. 95.8 N.A. 48.5 48.6 N.A. N.A. N.A. N.A. 86 N.A. 77.4 78 73.3 N.A.
P-Site Identity: 100 100 N.A. 100 N.A. 13.3 13.3 N.A. N.A. N.A. N.A. 100 N.A. 86.6 86.6 66.6 N.A.
P-Site Similarity: 100 100 N.A. 100 N.A. 20 20 N.A. N.A. N.A. N.A. 100 N.A. 93.3 93.3 80 N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. 51.4 N.A.
Protein Similarity: N.A. N.A. N.A. N.A. 69 N.A.
P-Site Identity: N.A. N.A. N.A. N.A. 60 N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. 73.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 20 0 0 20 0 10 0 0 0 0 10 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % D
% Glu: 0 0 60 0 0 0 0 0 0 20 0 0 0 0 0 % E
% Phe: 10 0 0 0 0 0 0 0 10 0 0 0 0 0 0 % F
% Gly: 0 0 0 80 0 0 0 0 0 80 80 0 0 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 20 70 0 0 0 0 0 0 0 0 0 % I
% Lys: 30 0 10 0 0 0 0 0 0 0 0 0 20 0 0 % K
% Leu: 0 0 0 20 0 0 70 0 0 0 0 0 60 0 20 % L
% Met: 0 0 0 0 0 0 0 0 70 0 0 0 0 0 0 % M
% Asn: 60 0 0 0 0 0 0 0 0 0 0 0 0 0 80 % N
% Pro: 0 80 0 0 0 0 0 0 0 0 0 0 0 70 0 % P
% Gln: 0 0 0 0 0 0 0 0 0 0 0 80 0 0 0 % Q
% Arg: 0 0 0 0 0 0 0 20 0 0 0 0 0 0 0 % R
% Ser: 0 20 10 0 0 0 20 70 0 0 0 20 0 10 0 % S
% Thr: 0 0 0 0 0 0 0 0 0 0 0 0 10 0 0 % T
% Val: 0 0 0 0 80 10 10 0 20 0 20 0 0 20 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _