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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: CAD All Species: 11.21
Human Site: S1900 Identified Species: 27.41
UniProt: P27708 Number Species: 9
    Phosphosite Substitution
    Charge Score: -0.11
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P27708 NP_004332.2 2225 242984 S1900 P P V P R Q A S P Q N L G T P
Chimpanzee Pan troglodytes XP_001155357 2225 242993 S1900 P P V P R Q A S P Q N L G T P
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_540124 2288 250188 S1963 P P V P R Q A S P Q N L G T P
Cat Felis silvestris
Mouse Mus musculus Q8C196 1500 164599 H1202 H V E D A G V H S G D A T L M
Rat Rattus norvegicus P07756 1500 164561 H1202 H V E D A G V H S G D A T L M
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus
Frog Xenopus laevis
Zebra Danio Brachydanio rerio NP_001009884 2230 247184 S1906 P P L A R I L S P Q A G Q P Q
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P05990 2224 246654 M1916 N P V A H S L M G K H I L A V
Honey Bee Apis mellifera XP_393888 2241 249499 P1916 K Y K S D S N P N L L L T A P
Nematode Worm Caenorhab. elegans NP_495838 2198 242563 A1897 I N R I F E L A D R Y K H D V
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P07259 2214 245107 R1887 E Q K L M S S R P P R E L V A
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.9 N.A. 94.8 N.A. 36.2 36.3 N.A. N.A. N.A. N.A. 76.8 N.A. 64.5 63.6 57.8 N.A.
Protein Similarity: 100 100 N.A. 95.8 N.A. 48.5 48.6 N.A. N.A. N.A. N.A. 86 N.A. 77.4 78 73.3 N.A.
P-Site Identity: 100 100 N.A. 100 N.A. 0 0 N.A. N.A. N.A. N.A. 40 N.A. 13.3 13.3 0 N.A.
P-Site Similarity: 100 100 N.A. 100 N.A. 6.6 6.6 N.A. N.A. N.A. N.A. 46.6 N.A. 33.3 13.3 20 N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. 51.4 N.A.
Protein Similarity: N.A. N.A. N.A. N.A. 69 N.A.
P-Site Identity: N.A. N.A. N.A. N.A. 6.6 N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. 13.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 20 20 0 30 10 0 0 10 20 0 20 10 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 20 10 0 0 0 10 0 20 0 0 10 0 % D
% Glu: 10 0 20 0 0 10 0 0 0 0 0 10 0 0 0 % E
% Phe: 0 0 0 0 10 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 0 0 0 20 0 0 10 20 0 10 30 0 0 % G
% His: 20 0 0 0 10 0 0 20 0 0 10 0 10 0 0 % H
% Ile: 10 0 0 10 0 10 0 0 0 0 0 10 0 0 0 % I
% Lys: 10 0 20 0 0 0 0 0 0 10 0 10 0 0 0 % K
% Leu: 0 0 10 10 0 0 30 0 0 10 10 40 20 20 0 % L
% Met: 0 0 0 0 10 0 0 10 0 0 0 0 0 0 20 % M
% Asn: 10 10 0 0 0 0 10 0 10 0 30 0 0 0 0 % N
% Pro: 40 50 0 30 0 0 0 10 50 10 0 0 0 10 40 % P
% Gln: 0 10 0 0 0 30 0 0 0 40 0 0 10 0 10 % Q
% Arg: 0 0 10 0 40 0 0 10 0 10 10 0 0 0 0 % R
% Ser: 0 0 0 10 0 30 10 40 20 0 0 0 0 0 0 % S
% Thr: 0 0 0 0 0 0 0 0 0 0 0 0 30 30 0 % T
% Val: 0 20 40 0 0 0 20 0 0 0 0 0 0 10 20 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 10 0 0 0 0 0 0 0 0 10 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _