Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.

Updated: 2017 Aug. 1

| Home | Kinexus | Contact | Credits

Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: CAD All Species: 9.39
Human Site: S292 Identified Species: 22.96
UniProt: P27708 Number Species: 9
    Phosphosite Substitution
    Charge Score: -0.11
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P27708 NP_004332.2 2225 242984 S292 S G R C F L T S Q N H G F A V
Chimpanzee Pan troglodytes XP_001155357 2225 242993 S292 S G R C F L T S Q N H G F A V
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_540124 2288 250188 S338 S G R C F L T S Q N H G F A V
Cat Felis silvestris
Mouse Mus musculus Q8C196 1500 164599
Rat Rattus norvegicus P07756 1500 164561
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus
Frog Xenopus laevis
Zebra Danio Brachydanio rerio NP_001009884 2230 247184 N294 R C Y I T S Q N H G F A V D P
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P05990 2224 246654 T302 L P C L H R A T G R C L M T S
Honey Bee Apis mellifera XP_393888 2241 249499 M304 R G T G R C Y M T M Q N H G F
Nematode Worm Caenorhab. elegans NP_495838 2198 242563 G289 P C T H Y A T G R C Y I T S Q
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P07259 2214 245107 R337 C T S T I S G R C Y I T S Q N
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.9 N.A. 94.8 N.A. 36.2 36.3 N.A. N.A. N.A. N.A. 76.8 N.A. 64.5 63.6 57.8 N.A.
Protein Similarity: 100 100 N.A. 95.8 N.A. 48.5 48.6 N.A. N.A. N.A. N.A. 86 N.A. 77.4 78 73.3 N.A.
P-Site Identity: 100 100 N.A. 100 N.A. 0 0 N.A. N.A. N.A. N.A. 0 N.A. 0 6.6 6.6 N.A.
P-Site Similarity: 100 100 N.A. 100 N.A. 0 0 N.A. N.A. N.A. N.A. 6.6 N.A. 6.6 6.6 33.3 N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. 51.4 N.A.
Protein Similarity: N.A. N.A. N.A. N.A. 69 N.A.
P-Site Identity: N.A. N.A. N.A. N.A. 0 N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. 0 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 10 10 0 0 0 0 10 0 30 0 % A
% Cys: 10 20 10 30 0 10 0 0 10 10 10 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 0 0 0 0 0 0 0 10 0 % D
% Glu: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % E
% Phe: 0 0 0 0 30 0 0 0 0 0 10 0 30 0 10 % F
% Gly: 0 40 0 10 0 0 10 10 10 10 0 30 0 10 0 % G
% His: 0 0 0 10 10 0 0 0 10 0 30 0 10 0 0 % H
% Ile: 0 0 0 10 10 0 0 0 0 0 10 10 0 0 0 % I
% Lys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % K
% Leu: 10 0 0 10 0 30 0 0 0 0 0 10 0 0 0 % L
% Met: 0 0 0 0 0 0 0 10 0 10 0 0 10 0 0 % M
% Asn: 0 0 0 0 0 0 0 10 0 30 0 10 0 0 10 % N
% Pro: 10 10 0 0 0 0 0 0 0 0 0 0 0 0 10 % P
% Gln: 0 0 0 0 0 0 10 0 30 0 10 0 0 10 10 % Q
% Arg: 20 0 30 0 10 10 0 10 10 10 0 0 0 0 0 % R
% Ser: 30 0 10 0 0 20 0 30 0 0 0 0 10 10 10 % S
% Thr: 0 10 20 10 10 0 40 10 10 0 0 10 10 10 0 % T
% Val: 0 0 0 0 0 0 0 0 0 0 0 0 10 0 30 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 10 0 10 0 10 0 0 10 10 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _