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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: CAD All Species: 9.09
Human Site: S569 Identified Species: 22.22
UniProt: P27708 Number Species: 9
    Phosphosite Substitution
    Charge Score: 0.11
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P27708 NP_004332.2 2225 242984 S569 G L G S G F A S N R E E L S A
Chimpanzee Pan troglodytes XP_001155357 2225 242993 S569 G L G S G F A S N R E E L S A
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_540124 2288 250188 S615 G L G S G F A S N R D E L S A
Cat Felis silvestris
Mouse Mus musculus Q8C196 1500 164599 F20 T L K S G F G F A N V T T K R
Rat Rattus norvegicus P07756 1500 164561 L20 T L K S G F G L A N V T S K R
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus
Frog Xenopus laevis
Zebra Danio Brachydanio rerio NP_001009884 2230 247184 N571 G L G S G F A N N R D E M I T
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P05990 2224 246654 N579 G L G S G F A N N E E E L Q S
Honey Bee Apis mellifera XP_393888 2241 249499 N581 G L G S G F A N S V K E L R N
Nematode Worm Caenorhab. elegans NP_495838 2198 242563 D566 G L G S G F A D N R E E L I A
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P07259 2214 245107 N612 G L G S G F A N N E K E L V D
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.9 N.A. 94.8 N.A. 36.2 36.3 N.A. N.A. N.A. N.A. 76.8 N.A. 64.5 63.6 57.8 N.A.
Protein Similarity: 100 100 N.A. 95.8 N.A. 48.5 48.6 N.A. N.A. N.A. N.A. 86 N.A. 77.4 78 73.3 N.A.
P-Site Identity: 100 100 N.A. 93.3 N.A. 26.6 26.6 N.A. N.A. N.A. N.A. 66.6 N.A. 73.3 60 86.6 N.A.
P-Site Similarity: 100 100 N.A. 100 N.A. 26.6 26.6 N.A. N.A. N.A. N.A. 86.6 N.A. 86.6 80 86.6 N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. 51.4 N.A.
Protein Similarity: N.A. N.A. N.A. N.A. 69 N.A.
P-Site Identity: N.A. N.A. N.A. N.A. 66.6 N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. 80 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 0 80 0 20 0 0 0 0 0 40 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 0 10 0 0 20 0 0 0 10 % D
% Glu: 0 0 0 0 0 0 0 0 0 20 40 80 0 0 0 % E
% Phe: 0 0 0 0 0 100 0 10 0 0 0 0 0 0 0 % F
% Gly: 80 0 80 0 100 0 20 0 0 0 0 0 0 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 0 0 0 0 0 0 0 0 20 0 % I
% Lys: 0 0 20 0 0 0 0 0 0 0 20 0 0 20 0 % K
% Leu: 0 100 0 0 0 0 0 10 0 0 0 0 70 0 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 10 0 0 % M
% Asn: 0 0 0 0 0 0 0 40 70 20 0 0 0 0 10 % N
% Pro: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % P
% Gln: 0 0 0 0 0 0 0 0 0 0 0 0 0 10 0 % Q
% Arg: 0 0 0 0 0 0 0 0 0 50 0 0 0 10 20 % R
% Ser: 0 0 0 100 0 0 0 30 10 0 0 0 10 30 10 % S
% Thr: 20 0 0 0 0 0 0 0 0 0 0 20 10 0 10 % T
% Val: 0 0 0 0 0 0 0 0 0 10 20 0 0 10 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _