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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: CAD All Species: 27.88
Human Site: Y645 Identified Species: 68.15
UniProt: P27708 Number Species: 9
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P27708 NP_004332.2 2225 242984 Y645 Q T L N D R E Y Q L L R Q T A
Chimpanzee Pan troglodytes XP_001155357 2225 242993 Y645 Q T L N D R E Y Q L L R Q T A
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_540124 2288 250188 Y691 Q T L N D R E Y Q L L R Q T A
Cat Felis silvestris
Mouse Mus musculus Q8C196 1500 164599 M96 Y K G Q I L T M A N P I I G N
Rat Rattus norvegicus P07756 1500 164561 M96 Y K G Q I L T M A N P I I G N
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus
Frog Xenopus laevis
Zebra Danio Brachydanio rerio NP_001009884 2230 247184 Y647 Q T L N D Y E Y N M L R N T A
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P05990 2224 246654 Y655 Q T L S D R E Y Q M L R S T A
Honey Bee Apis mellifera XP_393888 2241 249499 Y657 Q T L S N K E Y N M L R T T A
Nematode Worm Caenorhab. elegans NP_495838 2198 242563 Y642 Q T L S D R E Y N A L R T C A
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P07259 2214 245107 Y688 Q T L S D E D Y N M L R T T A
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.9 N.A. 94.8 N.A. 36.2 36.3 N.A. N.A. N.A. N.A. 76.8 N.A. 64.5 63.6 57.8 N.A.
Protein Similarity: 100 100 N.A. 95.8 N.A. 48.5 48.6 N.A. N.A. N.A. N.A. 86 N.A. 77.4 78 73.3 N.A.
P-Site Identity: 100 100 N.A. 100 N.A. 0 0 N.A. N.A. N.A. N.A. 73.3 N.A. 80 60 66.6 N.A.
P-Site Similarity: 100 100 N.A. 100 N.A. 0 0 N.A. N.A. N.A. N.A. 80 N.A. 93.3 86.6 73.3 N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. 51.4 N.A.
Protein Similarity: N.A. N.A. N.A. N.A. 69 N.A.
P-Site Identity: N.A. N.A. N.A. N.A. 60 N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. 80 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 0 0 0 20 10 0 0 0 0 80 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 10 0 % C
% Asp: 0 0 0 0 70 0 10 0 0 0 0 0 0 0 0 % D
% Glu: 0 0 0 0 0 10 70 0 0 0 0 0 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 20 0 0 0 0 0 0 0 0 0 0 20 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 20 0 0 0 0 0 0 20 20 0 0 % I
% Lys: 0 20 0 0 0 10 0 0 0 0 0 0 0 0 0 % K
% Leu: 0 0 80 0 0 20 0 0 0 30 80 0 0 0 0 % L
% Met: 0 0 0 0 0 0 0 20 0 40 0 0 0 0 0 % M
% Asn: 0 0 0 40 10 0 0 0 40 20 0 0 10 0 20 % N
% Pro: 0 0 0 0 0 0 0 0 0 0 20 0 0 0 0 % P
% Gln: 80 0 0 20 0 0 0 0 40 0 0 0 30 0 0 % Q
% Arg: 0 0 0 0 0 50 0 0 0 0 0 80 0 0 0 % R
% Ser: 0 0 0 40 0 0 0 0 0 0 0 0 10 0 0 % S
% Thr: 0 80 0 0 0 0 20 0 0 0 0 0 30 70 0 % T
% Val: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 20 0 0 0 0 10 0 80 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _