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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: CANX All Species: 22.42
Human Site: T50 Identified Species: 32.89
UniProt: P27824 Number Species: 15
    Phosphosite Substitution
    Charge Score: 0.13
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P27824 NP_001019820.1 592 67568 T50 E D S K P D T T A P P S S P K
Chimpanzee Pan troglodytes XP_001151304 592 67554 T50 E D S K P D T T A P P S S P K
Rhesus Macaque Macaca mulatta XP_001101429 592 67582 T50 E D S K P D T T A P P S S P K
Dog Lupus familis XP_533285 610 69806 N41 N S E E I D V N E G E L P S E
Cat Felis silvestris
Mouse Mus musculus P35564 591 67259 A51 D S K S K S D A S T P P S P K
Rat Rattus norvegicus P35565 591 67236 T51 D S K S K S D T S T P P S P K
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001506871 598 67609 S53 E D T K P E A S S P P P S P K
Chicken Gallus gallus NP_001025791 599 68090 S51 E D S N P E S S T P P P A P K
Frog Xenopus laevis NP_001080326 611 69964 S62 E E L K P E T S M P P P A P K
Zebra Danio Brachydanio rerio NP_998613 600 67856 P58 E E E E Q K A P A P P S A P T
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P29413 406 46790
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans P34652 619 69189 E42 K G S D D K E E F V P S L F V
Sea Urchin Strong. purpuratus XP_791226 591 66512 V45 Q V E E E E D V E P I E Q V E
Poplar Tree Populus trichocarpa
Maize Zea mays Q9SP22 420 47921
Rice Oryza sativa
Thale Cress Arabidopsis thaliana P29402 530 60468 E33 D D Q T V L Y E S F D E P F D
Baker's Yeast Sacchar. cerevisiae P27825 502 56949 N47 Y T N T K H L N Q E W I T S E
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.3 98.6 59.1 N.A. 93 93.5 N.A. 85.7 82.8 78.2 70.8 N.A. 31.7 N.A. 40.5 53.7
Protein Similarity: 100 99.8 99.4 75.2 N.A. 96.6 97.4 N.A. 93.1 90.8 86.2 84.1 N.A. 44.7 N.A. 58.9 69.7
P-Site Identity: 100 100 100 6.6 N.A. 26.6 33.3 N.A. 60 53.3 53.3 40 N.A. 0 N.A. 20 6.6
P-Site Similarity: 100 100 100 20 N.A. 40 46.6 N.A. 86.6 80 80 60 N.A. 0 N.A. 26.6 33.3
Percent
Protein Identity: N.A. 29.3 N.A. 40 25.6 N.A.
Protein Similarity: N.A. 44.4 N.A. 53.5 41.2 N.A.
P-Site Identity: N.A. 0 N.A. 6.6 0 N.A.
P-Site Similarity: N.A. 0 N.A. 20 20 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 0 13 7 25 0 0 0 19 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 19 38 0 7 7 25 19 0 0 0 7 0 0 0 7 % D
% Glu: 44 13 19 19 7 25 7 13 13 7 7 13 0 0 19 % E
% Phe: 0 0 0 0 0 0 0 0 7 7 0 0 0 13 0 % F
% Gly: 0 7 0 0 0 0 0 0 0 7 0 0 0 0 0 % G
% His: 0 0 0 0 0 7 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 7 0 0 0 0 0 7 7 0 0 0 % I
% Lys: 7 0 13 32 19 13 0 0 0 0 0 0 0 0 50 % K
% Leu: 0 0 7 0 0 7 7 0 0 0 0 7 7 0 0 % L
% Met: 0 0 0 0 0 0 0 0 7 0 0 0 0 0 0 % M
% Asn: 7 0 7 7 0 0 0 13 0 0 0 0 0 0 0 % N
% Pro: 0 0 0 0 38 0 0 7 0 50 63 32 13 57 0 % P
% Gln: 7 0 7 0 7 0 0 0 7 0 0 0 7 0 0 % Q
% Arg: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % R
% Ser: 0 19 32 13 0 13 7 19 25 0 0 32 38 13 0 % S
% Thr: 0 7 7 13 0 0 25 25 7 13 0 0 7 0 7 % T
% Val: 0 7 0 0 7 0 7 7 0 7 0 0 0 7 7 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 7 0 0 0 0 % W
% Tyr: 7 0 0 0 0 0 7 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _