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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: CANX All Species: 38.48
Human Site: Y229 Identified Species: 56.44
UniProt: P27824 Number Species: 15
    Phosphosite Substitution
    Charge Score: 0.07
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P27824 NP_001019820.1 592 67568 Y229 P D A D L K T Y F T D K K T H
Chimpanzee Pan troglodytes XP_001151304 592 67554 Y229 P D A D L K T Y F T D K K T H
Rhesus Macaque Macaca mulatta XP_001101429 592 67582 Y229 P D A D L K T Y F T D K K T H
Dog Lupus familis XP_533285 610 69806 F220 P D V D L K K F F T D R K T H
Cat Felis silvestris
Mouse Mus musculus P35564 591 67259 Y230 P D A D L K T Y F T D K K T H
Rat Rattus norvegicus P35565 591 67236 Y230 P D A D L K T Y F T D K K T H
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001506871 598 67609 Y232 P D A D L K T Y F T D K K T H
Chicken Gallus gallus NP_001025791 599 68090 Y230 P D A D L K T Y F T D K K T H
Frog Xenopus laevis NP_001080326 611 69964 Y241 P D A D L K S Y F T D K K T H
Zebra Danio Brachydanio rerio NP_998613 600 67856 Y237 P D S D L R S Y Y T D K K T H
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P29413 406 46790 H170 C K D D V Y T H F Y T L I V R
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans P34652 619 69189 Y221 P T T I G S T Y W D D H N T H
Sea Urchin Strong. purpuratus XP_791226 591 66512 V224 P T G A F S H V F T D K K A H
Poplar Tree Populus trichocarpa
Maize Zea mays Q9SP22 420 47921 P184 V Y T F I I R P D A T Y S I L
Rice Oryza sativa
Thale Cress Arabidopsis thaliana P29402 530 60468 D212 A N L L S G E D F E P A L I P
Baker's Yeast Sacchar. cerevisiae P27825 502 56949 V226 I D G K T V M V R E H I E D K
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.3 98.6 59.1 N.A. 93 93.5 N.A. 85.7 82.8 78.2 70.8 N.A. 31.7 N.A. 40.5 53.7
Protein Similarity: 100 99.8 99.4 75.2 N.A. 96.6 97.4 N.A. 93.1 90.8 86.2 84.1 N.A. 44.7 N.A. 58.9 69.7
P-Site Identity: 100 100 100 73.3 N.A. 100 100 N.A. 100 100 93.3 73.3 N.A. 20 N.A. 40 46.6
P-Site Similarity: 100 100 100 86.6 N.A. 100 100 N.A. 100 100 100 100 N.A. 33.3 N.A. 46.6 46.6
Percent
Protein Identity: N.A. 29.3 N.A. 40 25.6 N.A.
Protein Similarity: N.A. 44.4 N.A. 53.5 41.2 N.A.
P-Site Identity: N.A. 0 N.A. 6.6 6.6 N.A.
P-Site Similarity: N.A. 6.6 N.A. 13.3 13.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 7 0 50 7 0 0 0 0 0 7 0 7 0 7 0 % A
% Cys: 7 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 69 7 69 0 0 0 7 7 7 75 0 0 7 0 % D
% Glu: 0 0 0 0 0 0 7 0 0 13 0 0 7 0 0 % E
% Phe: 0 0 0 7 7 0 0 7 75 0 0 0 0 0 0 % F
% Gly: 0 0 13 0 7 7 0 0 0 0 0 0 0 0 0 % G
% His: 0 0 0 0 0 0 7 7 0 0 7 7 0 0 75 % H
% Ile: 7 0 0 7 7 7 0 0 0 0 0 7 7 13 0 % I
% Lys: 0 7 0 7 0 57 7 0 0 0 0 63 69 0 7 % K
% Leu: 0 0 7 7 63 0 0 0 0 0 0 7 7 0 7 % L
% Met: 0 0 0 0 0 0 7 0 0 0 0 0 0 0 0 % M
% Asn: 0 7 0 0 0 0 0 0 0 0 0 0 7 0 0 % N
% Pro: 75 0 0 0 0 0 0 7 0 0 7 0 0 0 7 % P
% Gln: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Q
% Arg: 0 0 0 0 0 7 7 0 7 0 0 7 0 0 7 % R
% Ser: 0 0 7 0 7 13 13 0 0 0 0 0 7 0 0 % S
% Thr: 0 13 13 0 7 0 57 0 0 69 13 0 0 69 0 % T
% Val: 7 0 7 0 7 7 0 13 0 0 0 0 0 7 0 % V
% Trp: 0 0 0 0 0 0 0 0 7 0 0 0 0 0 0 % W
% Tyr: 0 7 0 0 0 7 0 63 7 7 0 7 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _