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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HTR2C
All Species:
21.21
Human Site:
S457
Identified Species:
46.67
UniProt:
P28335
Number Species:
10
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P28335
NP_000859.1
458
51821
S457
V
V
S
E
R
I
S
S
V
_
_
_
_
_
_
Chimpanzee
Pan troglodytes
Q5IS66
458
51816
S457
V
V
S
E
R
I
S
S
V
_
_
_
_
_
_
Rhesus Macaque
Macaca mulatta
P50128
471
52585
C470
G
V
N
E
K
V
S
C
V
_
_
_
_
_
_
Dog
Lupus familis
Cat
Felis silvestris
Mouse
Mus musculus
P34968
459
51855
S458
V
V
S
E
R
I
S
S
V
_
_
_
_
_
_
Rat
Rattus norvegicus
P08909
460
51898
S459
V
V
S
E
R
I
S
S
V
_
_
_
_
_
_
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001514168
468
52300
S467
L
A
E
D
T
V
S
S
V
_
_
_
_
_
_
Chicken
Gallus gallus
XP_426265
472
52505
C471
V
V
S
E
R
V
S
C
V
_
_
_
_
_
_
Frog
Xenopus laevis
NP_001082744
453
50639
Y452
K
T
E
E
Q
A
S
Y
V
_
_
_
_
_
_
Zebra Danio
Brachydanio rerio
NP_001123365
518
56879
S517
S
H
T
E
H
T
S
S
V
_
_
_
_
_
_
Tiger Blowfish
Takifugu rubipres
O42385
423
46982
Fruit Fly
Dros. melanogaster
Q4LBB9
536
60360
N535
R
Q
S
Q
M
V
D
N
L
_
_
_
_
_
_
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.5
50.5
N.A.
N.A.
89.5
90.2
N.A.
50.4
59.1
42.1
49.2
22.4
27
N.A.
N.A.
N.A.
Protein Similarity:
100
99.7
65.3
N.A.
N.A.
93.6
93.6
N.A.
65.8
75.2
65.2
63.3
40.3
44.9
N.A.
N.A.
N.A.
P-Site Identity:
100
100
44.4
N.A.
N.A.
100
100
N.A.
33.3
77.7
33.3
44.4
0
11.1
N.A.
N.A.
N.A.
P-Site Similarity:
100
100
77.7
N.A.
N.A.
100
100
N.A.
66.6
88.8
44.4
55.5
0
55.5
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
10
0
0
0
10
0
0
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
19
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
10
0
0
10
0
0
0
0
0
0
0
0
% D
% Glu:
0
0
19
73
0
0
0
0
0
0
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
10
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% G
% His:
0
10
0
0
10
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
37
0
0
0
0
0
0
0
0
0
% I
% Lys:
10
0
0
0
10
0
0
0
0
0
0
0
0
0
0
% K
% Leu:
10
0
0
0
0
0
0
0
10
0
0
0
0
0
0
% L
% Met:
0
0
0
0
10
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
10
0
0
0
0
10
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
10
0
10
10
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
10
0
0
0
46
0
0
0
0
0
0
0
0
0
0
% R
% Ser:
10
0
55
0
0
0
82
55
0
0
0
0
0
0
0
% S
% Thr:
0
10
10
0
10
10
0
0
0
0
0
0
0
0
0
% T
% Val:
46
55
0
0
0
37
0
0
82
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
10
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
91
91
91
91
91
91
% _