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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HTR2C
All Species:
30.61
Human Site:
T169
Identified Species:
67.33
UniProt:
P28335
Number Species:
10
Phosphosite Substitution
Charge Score:
-0.2
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P28335
NP_000859.1
458
51821
T169
H
S
R
F
N
S
R
T
K
A
I
M
K
I
A
Chimpanzee
Pan troglodytes
Q5IS66
458
51816
T169
H
S
R
F
N
S
R
T
K
A
I
M
K
I
A
Rhesus Macaque
Macaca mulatta
P50128
471
52585
T190
H
S
R
F
N
S
R
T
K
A
F
L
K
I
I
Dog
Lupus familis
Cat
Felis silvestris
Mouse
Mus musculus
P34968
459
51855
T170
H
S
R
F
N
S
R
T
K
A
I
M
K
I
A
Rat
Rattus norvegicus
P08909
460
51898
T170
H
S
R
F
N
S
R
T
K
A
I
M
K
I
A
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001514168
468
52300
T190
H
S
R
F
N
S
R
T
K
A
F
V
K
I
I
Chicken
Gallus gallus
XP_426265
472
52505
T181
H
S
R
F
N
S
R
T
K
A
I
M
K
I
A
Frog
Xenopus laevis
NP_001082744
453
50639
P168
P
I
K
G
L
L
D
P
N
T
T
F
S
A
S
Zebra Danio
Brachydanio rerio
NP_001123365
518
56879
T184
H
S
R
F
N
S
R
T
K
A
M
L
K
I
A
Tiger Blowfish
Takifugu rubipres
O42385
423
46982
R161
V
N
K
R
T
P
R
R
A
A
V
L
I
S
V
Fruit Fly
Dros. melanogaster
Q4LBB9
536
60360
R268
Y
P
I
S
M
T
K
R
V
V
G
I
M
L
L
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.5
50.5
N.A.
N.A.
89.5
90.2
N.A.
50.4
59.1
42.1
49.2
22.4
27
N.A.
N.A.
N.A.
Protein Similarity:
100
99.7
65.3
N.A.
N.A.
93.6
93.6
N.A.
65.8
75.2
65.2
63.3
40.3
44.9
N.A.
N.A.
N.A.
P-Site Identity:
100
100
80
N.A.
N.A.
100
100
N.A.
80
100
0
86.6
13.3
0
N.A.
N.A.
N.A.
P-Site Similarity:
100
100
86.6
N.A.
N.A.
100
100
N.A.
86.6
100
13.3
100
40
33.3
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
0
10
82
0
0
0
10
55
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
10
0
0
0
0
0
0
0
0
% D
% Glu:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% E
% Phe:
0
0
0
73
0
0
0
0
0
0
19
10
0
0
0
% F
% Gly:
0
0
0
10
0
0
0
0
0
0
10
0
0
0
0
% G
% His:
73
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
10
10
0
0
0
0
0
0
0
46
10
10
73
19
% I
% Lys:
0
0
19
0
0
0
10
0
73
0
0
0
73
0
0
% K
% Leu:
0
0
0
0
10
10
0
0
0
0
0
28
0
10
10
% L
% Met:
0
0
0
0
10
0
0
0
0
0
10
46
10
0
0
% M
% Asn:
0
10
0
0
73
0
0
0
10
0
0
0
0
0
0
% N
% Pro:
10
10
0
0
0
10
0
10
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
73
10
0
0
82
19
0
0
0
0
0
0
0
% R
% Ser:
0
73
0
10
0
73
0
0
0
0
0
0
10
10
10
% S
% Thr:
0
0
0
0
10
10
0
73
0
10
10
0
0
0
0
% T
% Val:
10
0
0
0
0
0
0
0
10
10
10
10
0
0
10
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
10
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _