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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: MAPK1 All Species: 52.12
Human Site: S246 Identified Species: 88.21
UniProt: P28482 Number Species: 13
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P28482 NP_002736.3 360 41390 S246 H I L G I L G S P S Q E D L N
Chimpanzee Pan troglodytes XP_510921 379 43006 S263 H I L G I L G S P S Q E D L N
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_860750 375 42862 S246 H I L G I L G S P S Q E D L N
Cat Felis silvestris
Mouse Mus musculus Q63844 380 43048 S264 H I L G I L G S P S Q E D L N
Rat Rattus norvegicus P63086 358 41257 S244 H I L G I L G S P S Q E D L N
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus NP_989481 368 41924 S254 H I L G I L G S P S Q E D L N
Frog Xenopus laevis P26696 361 41238 S249 H I L G I L G S P S Q E D L N
Zebra Danio Brachydanio rerio NP_878308 369 42057 S255 H I L G I L G S P S Q E D L N
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P40417 426 49103 S309 H I L G V L G S P S R D D L E
Honey Bee Apis mellifera XP_393029 371 42705 S248 H I L G V L G S P S P E D L E
Nematode Worm Caenorhab. elegans P39745 444 50644 S317 L I L A V V G S P S N A D L Q
Sea Urchin Strong. purpuratus NP_999813 369 42176 S252 H I L G V L G S P S Q D D L K
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q39024 376 42833 S262 L I T E L I G S P D D S S L G
Baker's Yeast Sacchar. cerevisiae P16892 353 40754 T241 L I F G I I G T P H S D N D L
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 78 N.A. 96 N.A. 83.4 99.1 N.A. N.A. 97.2 95.8 92.1 N.A. 67.8 81.9 64.4 79.4
Protein Similarity: 100 85.4 N.A. 96 N.A. 89.2 99.4 N.A. N.A. 97.5 97.2 94.5 N.A. 74.6 86.7 70.9 84.5
P-Site Identity: 100 100 N.A. 100 N.A. 100 100 N.A. N.A. 100 100 100 N.A. 73.3 80 53.3 80
P-Site Similarity: 100 100 N.A. 100 N.A. 100 100 N.A. N.A. 100 100 100 N.A. 93.3 86.6 66.6 93.3
Percent
Protein Identity: N.A. N.A. N.A. 48.6 49.7 N.A.
Protein Similarity: N.A. N.A. N.A. 65.4 66.3 N.A.
P-Site Identity: N.A. N.A. N.A. 33.3 33.3 N.A.
P-Site Similarity: N.A. N.A. N.A. 46.6 60 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 8 0 0 0 0 0 0 0 8 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 0 0 0 8 8 22 86 8 0 % D
% Glu: 0 0 0 8 0 0 0 0 0 0 0 65 0 0 15 % E
% Phe: 0 0 8 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 0 86 0 0 100 0 0 0 0 0 0 0 8 % G
% His: 79 0 0 0 0 0 0 0 0 8 0 0 0 0 0 % H
% Ile: 0 100 0 0 65 15 0 0 0 0 0 0 0 0 0 % I
% Lys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 8 % K
% Leu: 22 0 86 0 8 79 0 0 0 0 0 0 0 93 8 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 0 0 0 8 0 8 0 58 % N
% Pro: 0 0 0 0 0 0 0 0 100 0 8 0 0 0 0 % P
% Gln: 0 0 0 0 0 0 0 0 0 0 65 0 0 0 8 % Q
% Arg: 0 0 0 0 0 0 0 0 0 0 8 0 0 0 0 % R
% Ser: 0 0 0 0 0 0 0 93 0 86 8 8 8 0 0 % S
% Thr: 0 0 8 0 0 0 0 8 0 0 0 0 0 0 0 % T
% Val: 0 0 0 0 29 8 0 0 0 0 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _